Characteristics Comment References Age Advanced chronological age is an independent predictor of DR, CSM, and OM [12–14] Gender No impact of gender on outcomes [15] Race Afro-American race independent predictor…
Fig. 1.1 Molecular biology of Lynch syndrome. During replication, DNA polymerase slips on highly repetitive microsatellites. Proficient MMR repairs these slips in normal cells, but they persist in those without…
Fig. 2.1 Preoperative nomogram for prediction of organ-confined stage of the UTUC (adapted from Margulis V, et al.: Preoperative multivariable prognostic model for prediction of nonorgan confined urothelial carcinoma of…
Study Setting Inclusion criteria N= Regimen Primary outcomes pCR Survival at 5 years Prospective Siefker Radtke et al. ASCO GU 2012 [35] Neoadjuvant 16 Dose dense MVAC + Bevacizumab…
Study N pat. Median F/U [mo.] N (EV) N (IV) N (TUI) 5-year bladder RFS [%] (EV) 5-year bladder RFS [%] (IV) 5-year bladder RFS [%] (TUI) Li et al….
Risk References Patient factors Age* Increasing age associated with worse disease survival [7, 8] Race Disease-specific annual mortality greater in black than in white individuals [9] Gender Females are…
Target of investigation Available tests Antisperm antibodies Mixed agglutination reaction (MAR) test Direct immunobeads binding test (direct IBT) Fertilization defects Hemizona assay Sperm–zona binding ratio test Hyperactivation (HA) motility Acrosome…
Fig. 28.1 Human ovarian steroidogenesis. The starting point for steroid biosynthesis is the conversion of cholesterol in pregnenolone by P450scc. One route of pregnenolone metabolism is the delta-5 pathway (…
Parameter Unexplained male infertility Idiopathic male infertility Semen analysis [1, 2, 6] Normal Abnormal History, physical exam, and endocrine assessment [2, 3, 14] Normal Normal Female factor infertility [2, 6]…
Fig. 18.1 Normal fallopian tube. Salpingoscopy reveals normal-looking mucosa in the ampullary (a) and infundibular (b) regions. A thin section of the ampulla (c) shows normal ciliated endosalpinx. Electron microscopy…
