© Springer Science+Business Media New York 2014Gary R. Lichtenstein (ed.)Medical Therapy of Ulcerative Colitis10.1007/978-1-4939-1677-1_23 23. Treatment of Severe Ulcerative Colitis Seamus J. Murphy1 and Asher Kornbluth2 (1) Department of Medicine, Daisy Hill Hospital, 5 Hospital Road, Newry,…
Antibiotics • No definitive cause between early use and IBD • Most studied include tetracyclines, penicillin Oral contraceptives • Weak association with CD that increases with length of exposure • Risk reverts to nonexposed…
Systemic Hydrocortisone (in alcohol or as a hemisuccinate sodium) Prednisolone-21 phosphate Betamethasone Nonsystemic steroids Prednisolone metasulfobenzoate Beclomethasone dipropionate Budesonide Glucocorticoids Mechanisms of Action Glucocorticoid activity is dependent on specific glucocorticoid…
20. Baumgart DC. Extended colonic release low-molecular weight heparin (LMWH) not ready for use in ulcerative colitis. Evid Based Med. 2011;16:71–2.PubMed 21. Tytgat GN, Van Nueten L, Van De Velde…
Author Ref. Maintenance or induction of remission Probiotic Comparator Study duration UC population Primary clinical outcome Results Treatment arm Control arm(s) Tursi et al. [49] Induction of remission VSL#3 + balsalazide Balsalazide…
Clinical trials ACT1/ACT2 ULTRA1/ULTRA2 PURSUIT-SC Placebo (n = 121/123) IFX 5 mg/kg (n = 121/121) IFX 10 mg/kg (n = 122/120) Placebo (n = 130/246) ADA 80/40 (n = 130/–) ADA 160/80 (n = 130/248) Placebo (n = 331) GLM 100/50 (n = 72) GLM 200/100…
Drug FDA approval FDA-approved indication in ulcerative colitis Prednisolone 1972 To tide the patient over a critical period of the disease in ulcerative colitis Sulfasalazine 1977 Treatment of mild to…
Fig. 15.1 Mucosal healing 14 weeks after introduction of infliximab. Endoscopic images of the sigmoid at baseline (upper panel) and at week 14 (lower panel) in a patient receiving infliximab…
© Springer Science+Business Media New York 2014Gary R. Lichtenstein (ed.)Medical Therapy of Ulcerative Colitis10.1007/978-1-4939-1677-1_14 14. Tacrolimus, Sirolimus, and Mycophenolate Mofetil Andreas Fischer1 and Daniel C. Baumgart1 (1) Department of Medicine, Division of Gastroenterology and Hepatology Charité Medical…
Fig. 12.1 Azathioprine (AZA) metabolism. XO xanthine oxidase, 6-TU 6-thiouric acid, and 6-TIMP 6-thioinosine monophosphate An apparent genetic polymorphism has been observed in TPMT activity in both the Caucasian and…
