Patient Perspective on Inflammatory Bowel Disease
Initial questions may include: Practical questions may include: What is Crohn’s disease or ulcerative colitis? Where is the nearest bathroom and will I have access to it? Is it contagious?…
Inflammatory Bowel Diseases: How to Identify High-Risk Patients
Relative importance References Age < 17 years +++ [3, 110] Perianal disease ++ [8, 9] Need for steroids ++ [8, 9, 111] Ileocolonic location + [9, 112] Age <…
Pediatric Aspects of Inflammatory Bowel Disease
© Springer International Publishing AG 2017Daniel C. Baumgart (ed.)Crohn’s Disease and Ulcerative Colitis10.1007/978-3-319-33703-6_58 58. Pediatric Aspects of Inflammatory Bowel Disease Brendan Boyle1 and Jeffrey S. Hyams2, 3 (1) Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children’s…
Pregnancy and Fertility in Inflammatory Bowel Disease
Time period Important points Preconception – Establish care with multidisciplinary team: primary care physician, obstetrician, maternal–fetal specialist, gastroenterologist – Discontinue medications that may be harmful to fetus (i.e. methotrexate) – Update health care…
Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab
© Springer International Publishing AG 2017Daniel C. Baumgart (ed.)Crohn’s Disease and Ulcerative Colitis10.1007/978-3-319-33703-6_42 42. Biologic Therapy in Moderate-to-Severe Ulcerative Colitis: Infliximab Mindy Lam1 and Brian Bressler1 (1) Division of Gastroenterology, University of British Columbia, Vancouver, BC,…
Conventional Therapy of Ulcerative Colitis: Corticosteroids
Study Corticosteroid (starting dose) Comparator No. of patients Disease extent Duration (weeks) End-points Remission NNT (95 % CI) Intravenous Meyers [6] 1983 Hydrocortisone (300 mg daily) Corticotropin (ACTH) 120 U/day…
Conventional Medical Management of Crohn’s Disease: Methotrexate
Fig. 31.1 Methotrexate (MTX) metabolism . MTX and its polyglutamate metabolites (MTXPG) potently inhibit dihydrofolate reductase (DHFR), impairing the conversion of dihydrofolate (FH2) to tetrahydrofolate (FH4). MTXPG also inhibit folate-dependent…
Steroid Therapy for Crohn’s Disease
© Springer International Publishing AG 2017Daniel C. Baumgart (ed.)Crohn’s Disease and Ulcerative Colitis10.1007/978-3-319-33703-6_29 29. Steroid Therapy for Crohn’s Disease A. Hillary Steinhart1 (1) IBD Centre, Mount Sinai Hospital and Department of Medicine, University of Toronto, Room…
Conventional Medical Management of Crohn’s Disease: Sulfasalazine
© Springer International Publishing AG 2017Daniel C. Baumgart (ed.)Crohn’s Disease and Ulcerative Colitis10.1007/978-3-319-33703-6_28 28. Conventional Medical Management of Crohn’s Disease: Sulfasalazine Miquel A. Gassull1, 2 and Eduard Cabré3, 4 (1) Health Science Research Institute, Germans Trias i…
The Natural History of Inflammatory Bowel Disease
1. Approximately one third of patients has chronically active disease or fluctuating disease and hence this is the cohort most likely to be treated by more aggressive immunomodulating therapy. However,…
