Fig. 14.1 Hepatitis B life cycle, showing nuclear and cytoplasmic stages of HBV infection and sites of action for current and future HBV treatments Two forms of RNA molecule are…
Fig. 9.1 GlobalHepatitis B Prevalence 2005 (adults 19–45 years old). Source: J.J. Ott et al./Vaccine 30 (2012) 2212–2219 About 60 % of the global population lives in areas of high…
Fig. 7.1 (a) Schematic representation of the HBV virions, HDV virions, and HBV subviral particles (SVPs). The HBV DNA genome and the HDV RNA genomes are represented as circular molecules….
© Springer International Publishing Switzerland 2016Yun-Fan Liaw and Fabien Zoulim (eds.)Hepatitis B Virus in Human DiseasesMolecular and Translational Medicine10.1007/978-3-319-22330-8_20 20. Towards HBV Eradication: Future Perspective Yun-Fan Liaw1 and Fabien Zoulim2, 3, 4 (1) Liver Research Unit, Chang…
Phase Lab characteristics Acute HBV infection – HBsAg positive <6 months, anti-HBc IgM positive – HBeAg positive, HBV DNA positive – Normal ALT or elevated ALT (symptomatic patients have usually…
Fig. 2.1 Comparison of the different in vitro and in vivo systems currently available for HBV research with respect to application and limitation In 2002 a bipotent progenitor cell line,…
© Springer International Publishing Switzerland 2016Yun-Fan Liaw and Fabien Zoulim (eds.)Hepatitis B Virus in Human DiseasesMolecular and Translational Medicine10.1007/978-3-319-22330-8_15 15. IFN-Based Therapy and Management of Patients Victor C. K. Lo1 and Harry L. A. Janssen2, 1 (1) Toronto Centre for Liver…
Fig. 4.1 Hepatic effector CD8+ T cell accumulation requires platelets that have adhered to liver sinusoids. Confocal micrographs of the liver of a HBV replication-competent transgenic mouse that was injected…
Fig. 8.1 Information derived from the analysis of human samples in viral hepatitis In Vivo Models of HBV Infection: What Do They Mimic? HBV infection causes acute and chronic liver…
Fig. 2.1 Two-layers of anti-inflammatory mucosal immune defense preserving the integrity of the intestinal epithelial barrier. Depiction of the homeostatic mechanisms: (1) Immune exclusion to control epithelial colonization of microorganisms…
