Chronic Hepatitis
CHAPTER 9 Chronic Hepatitis Definition and causes Chronic hepatitis is a common reason for persistently abnormal liver function tests1 and forms the background for the development of much cirrhosis2 and…
Disturbances of Copper and Iron Metabolism
CHAPTER 14 Disturbances of Copper and Iron Metabolism Wilson’s disease (hepatolenticular degeneration) Wilson’s disease is an autosomal recessive disorder due to mutations in the gene ATP7B for copper-transporting ATPase located…
Steatosis, Steatohepatitis and Related Conditions
CHAPTER 7 Steatosis, Steatohepatitis and Related Conditions Steatosis Steatosis (fatty change, fatty liver) is the accumulation of abnormal amounts of lipid in hepatocytes. Most steatosis is of the macrovesicular type,…
Acute Viral Hepatitis
CHAPTER 6 Acute Viral Hepatitis Introduction Acute hepatitis is not usually an indication for liver biopsy. There are, however, at least three reasons why pathologists sometimes receive liver biopsy samples…
Vascular Disorders
CHAPTER 12 Vascular Disorders The hepatic arteries The effects of occlusion of hepatic artery branches are unpredictable because of the liver’s double blood supply and variable collateral flow. Potential effects…
Electron Microscopy and Other Techniques
CHAPTER 17 Electron Microscopy and Other Techniques Introduction This chapter will focus primarily on the role of transmission electron microscopy in the assessment of liver ultrastructure and disease. It also…
Drugs and Toxins
CHAPTER 8 Drugs and Toxins Introduction This chapter deals with the pathology of the important liver lesions attributed to drugs and toxins, with their recognition, and with their differential diagnosis….
The Normal Liver
CHAPTER 3 The Normal Liver Structures and components Functional units and nomenclature Under the low power of the light microscope, normal liver is seen to have a regular structure based…
Assessment and Differential Diagnosis of Pathological Features
CHAPTER 4 Assessment and Differential Diagnosis of Pathological Features Initial examination and reporting Naked-eye examination and description of biopsy specimens Although naked-eye examination and description are of limited diagnostic value,…
