and Manu R. Sood2, 3 (1) Children’s Hospital Medical Center, Cincinnati, OH, USA (2) Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatric, Medical College of Wisconsin, Milwaukee, WI, USA (3)…
and Justin Vandergrift2 (1) Chapel Hill, North Carolina, USA (2) Charlotte, North Carolina, USA KeywordsSelf-managementAdherencePatient activationCo-production Introduction As chronic medical conditions, such as inflammatory bowel disease (IBD), predominate as a…
Fig. 23.1 Normal mucosal findings (a) in the mid-small bowel as seen by wireless capsule endoscopy in a child suspected of Crohn disease. The astonishing resolution of the capsule’s lens…
Fig. 2.1 The anatomy of the intestinal immune system. The basic organizational structure of the intestinal immune system. The follicular-associated epithelium (FAE) contains M (microfold) cells which transport antigen into…
Fig. 35.1 Drugs in pipeline for CD (Amiot and Peyrin-Biroulet [1]) Fig. 35.2 Drugs in pipeline for UC (Amiot and Peyrin-Biroulet [1]) Table 35.1 Treatments discussed in this chapter Target…
Fig. 15.1 Evaluation of child with suspected IBD. Atypical UC is a new IBD category consisting of 5 phenotypes and reflects a phenotype that should be treated as UC. IBD-U…
Drug Formulation Delivery system Dosage form Release location Azo-bonded formulations Sulfasalazine (Azulfidine®) Azo bond of 5-ASA to sulfapyridine Broken down by colonic bacteria to release active 5-ASA moiety Tablet 500…
Participants [# Treated] Trial design Probiotic (strains) Dosing (CFU/day) Trial length (months) Ref. 103 [50] DBRDD Single strain (E. coli Nissle) 5 × 1010 3 [45] 327 [162] DBRDD Single…
Fig. 24.1 Bone formation (+) and resorption (−) during growth (From: Baron [12]) Changes in Cortical and Trabecular Bone with Growth Cortical and trabecular bone do not respond in the…
Fig. 12.1 The GH/IGF-1 axis and its role in linear growth. The hypothalamic release of growth hormone releasing hormone (GHRH) stimulates the pulsatile release of growth hormone (GH) from the…
