Video Capsule Endoscopy in Inflammatory Bowel Disease
Fig. 23.1 Normal mucosal findings (a) in the mid-small bowel as seen by wireless capsule endoscopy in a child suspected of Crohn disease. The astonishing resolution of the capsule’s lens…
The Intestinal Immune System During Homeostasis and Inflammatory Bowel Disease
Fig. 2.1 The anatomy of the intestinal immune system. The basic organizational structure of the intestinal immune system. The follicular-associated epithelium (FAE) contains M (microfold) cells which transport antigen into…
New Non-anti-TNF-α Biological Therapies for the Treatment of Inflammatory Bowel Disease
Fig. 35.1 Drugs in pipeline for CD (Amiot and Peyrin-Biroulet [1]) Fig. 35.2 Drugs in pipeline for UC (Amiot and Peyrin-Biroulet [1]) Table 35.1 Treatments discussed in this chapter Target…
Classification of Inflammatory Bowel Disease in Children
Fig. 15.1 Evaluation of child with suspected IBD. Atypical UC is a new IBD category consisting of 5 phenotypes and reflects a phenotype that should be treated as UC. IBD-U…
5-Aminosalicylate Therapy
Drug Formulation Delivery system Dosage form Release location Azo-bonded formulations Sulfasalazine (Azulfidine®) Azo bond of 5-ASA to sulfapyridine Broken down by colonic bacteria to release active 5-ASA moiety Tablet 500…
Probiotic Therapy
Participants [# Treated] Trial design Probiotic (strains) Dosing (CFU/day) Trial length (months) Ref. 103 [50] DBRDD Single strain (E. coli Nissle) 5 × 1010 3 [45] 327 [162] DBRDD Single…
Bone Health in Pediatric Inflammatory Bowel Disease
Fig. 24.1 Bone formation (+) and resorption (−) during growth (From: Baron [12]) Changes in Cortical and Trabecular Bone with Growth Cortical and trabecular bone do not respond in the…
Growth Impairment in Pediatric Inflammatory Bowel Disease
Fig. 12.1 The GH/IGF-1 axis and its role in linear growth. The hypothalamic release of growth hormone releasing hormone (GHRH) stimulates the pulsatile release of growth hormone (GH) from the…
Measurement of Quality of Life in Pediatric Inflammatory Bowel Disease
Fig. 51.1 Conceptual scheme of the domains and variables involved in a quality-of-life assessment. The x axis represents subjective perceptions of health, the y axis represents objective health status, the…
Therapeutic Drug Monitoring in Pediatric Inflammatory Bowel Disease
Fig. 34.1 Azathioprine/6-mercaptopurine metabolism pathways. AZA azathioprine, GMPS guanosine monophosphate synthetase, HPRT hypoxanthine phosphoribosyltransferase, IMPDH inosine monophosphate dehydrogenase, 6-MMP 6-methylmercaptopurine, 6-MP 6-mercaptopurine, 6-TG 6-thioguanine, 6-TIMP 6-thioinosine monophosphate, TPMT thiopurine S-methyltransferase,…
