Fig. 18.1 Practical strategies for improving safety of biologic therapies Choice of Biologic Agents There are eight FDA-approved biologic agents to treat IBD, generally indicated for patients with active disease…
Crohn’s disease Mechanism Ulcerative colitis Vedoli zumab (approved) Anti-integrin Vedolizumab (approved) Etrolizumab (phase III) Etrolizumab (phase III) PF-00547659 (phase II) PF-00547659 (phase II) Ozanimod (phase II) Sphingosine-1-phosphate inhibitor Ozanimod (phase…
© Springer International Publishing AG 2018Adam S. Cheifetz and Joseph D. Feuerstein (eds.)Treatment of Inflammatory Bowel Disease with Biologics https://doi.org/10.1007/978-3-319-60276-9_12 12. Infectious Complications of Biologics Renée M. Marchioni Beery1 and Joshua R. Korzenik1 (1) Division of Gastroenterology, Hepatology, and…
© Springer International Publishing AG 2018Adam S. Cheifetz and Joseph D. Feuerstein (eds.)Treatment of Inflammatory Bowel Disease with Biologics https://doi.org/10.1007/978-3-319-60276-9_11 11. Biologic Therapy in Pediatric Inflammatory Bowel Disease Sonal Patel1 and Jennifer Strople1 (1) Division of Pediatric…
Authors Number of participants (n) Study design Relapse rate Significant predictors of relapse Predictors evaluated but not found to be significant Recapture rate CD Brooks et al. [52] 86…
Study Infliximab (n) Non-infliximab (n) Total (n) Odds ratio Appau et al. [8] 60 329 389 2.93 (1.63–5.27) Canedo et al. [11] 65 160 225 1.19 (0.58–2.42) Kasparek et al….
Fig. 3.1 Induction of remission with corresponding placebo rates from seminal clinical trials for each anti-TNF (note: trials had different inclusion criteria and end points and thus while presented on…
Infliximab Adalimumab Certolizumab Golimumab CT-P13 ABP501 sTNF binding Y Y Y Y Y Y mTNF binding Y Y Y Y Y Y mTNF reverse signaling Y Y ? Y…
© Springer International Publishing AG 2018Adam S. Cheifetz and Joseph D. Feuerstein (eds.)Treatment of Inflammatory Bowel Disease with Biologics https://doi.org/10.1007/978-3-319-60276-9_4 4. Anti-TNF Therapy for Treatment of Extraintestinal Manifestations of Inflammatory Bowel Disease David I. Fudman1 and Sarah N. Flier1 …
Term Definition Adverse pregnanc y outcomes Spontaneous abortion/miscarriage Induced abortion Preterm birth (delivery <37 weeks of gestation) Small for gestational age (birth weight <10th percentile for gestational age) Stillbirth Ectopic…
