Enrollment criteria PSAD <0.15, clinical stage T1c, Gleason score ≤6, ≤2 positive cores, and ≤50% involvement of any core (preferred); or PSA <10, clinical stage ≤T2a, and Gleason score ≤6 Monitoring PSA + DRE every…
© Springer International Publishing AG 2018Laurence Klotz (ed.)Active Surveillance for Localized Prostate CancerCurrent Clinical Urologyhttps://doi.org/10.1007/978-3-319-62710-6_17 17. Is There a Role for Pharmacologic Manipulation to Prevent Progression in Men on Active Surveillance? The Role of…
Fig. 2.1 Scheme depicting the age-related natural history of five hypothetical forms of prostate cancer (presented by the curved lines I–V) in relationship to their clinical signs and symptoms ,…
Name of trial (NCT No.) Start Subjects Inclusion criteria Intervention Outcomes (primary, secondary, tertiary) Feasibility Study on a Nordic Lifestyle Intervention Trial Among Men With Prostate Cancer (NCT01300104) Feb 2011…
Authors, journal, year Country Study design Therapies and number of participants per study group Measures Number of measurements AS compared to curative treatment 1. Jeldres et al., cancer, 2015 [15]…
Fig. 5.1 Recurrence-free progression following radical prostatectomy stratified by prostatectomy grade. Green line: Gleason score 6, Grade Group 1. Orange line: Gleason score 3 + 4, Grade Group 2. Dark blue line:…
Fig. 1.1 This illustrates the difference between a true epidemic of serious disease, where a rise in incidence is paralleled by an increase in mortality, and a “pseudo-epidemic” or overdiagnosis,…
© Springer International Publishing AG 2018Laurence Klotz (ed.)Active Surveillance for Localized Prostate CancerCurrent Clinical Urologyhttps://doi.org/10.1007/978-3-319-62710-6_3 3. The Role of Fear in Overdiagnosis and Overtreatment Iona Heath1 (1) Royal College of General Practitioners, London, UK …
Clinical stage PSA (ng/mL) Gleason score on biopsy PSA density Number of positive cores on biopsy University of Toronto, Canada [7] T1c/T2a ≤10–15 ≤3 + 4 (1.4% of cohort were 4 + 3)…
© Springer International Publishing AG 2018Laurence Klotz (ed.)Active Surveillance for Localized Prostate CancerCurrent Clinical Urologyhttps://doi.org/10.1007/978-3-319-62710-6_4 4. Ethical and Legal Considerations in Active Surveillance for Prostate Cancer Lionne D. F. Venderbos1 (1) Department of Urology, Erasmus University Medical…
