Research Questions in Active Surveillance
Name N Intervention Outcome Nordic lifestyle 2011 24 Vigorous exercise > = 3 ×/week, rye PCa progression Diet in PCa 2011 464 Dietary education and telephone counseling × 2 years Clinical progression, TTP…
Tissue Preservation: Active Surveillance and Focal Therapy as Complimentary Strategies
Fig. 19.1 New risk definitions in prostate cancer. Traffic light system Yellow disease represents a tumour focus greater than 0.2 cc but less than 0.5 cc as predicted by the maximum cancer…
The Update of Active Surveillance Around the World: Utilization and Outcomes
Enrollment criteria PSAD <0.15, clinical stage T1c, Gleason score ≤6, ≤2 positive cores, and ≤50% involvement of any core (preferred); or PSA <10, clinical stage ≤T2a, and Gleason score ≤6 Monitoring PSA + DRE every…
Is There a Role for Pharmacologic Manipulation to Prevent Progression in Men on Active Surveillance? The Role of 5-ARIs, Statins, and Metformin
© Springer International Publishing AG 2018Laurence Klotz (ed.)Active Surveillance for Localized Prostate CancerCurrent Clinical Urologyhttps://doi.org/10.1007/978-3-319-62710-6_17 17. Is There a Role for Pharmacologic Manipulation to Prevent Progression in Men on Active Surveillance? The Role of…
Can We Screen and Still Reduce Overdiagnosis?
Fig. 2.1 Scheme depicting the age-related natural history of five hypothetical forms of prostate cancer (presented by the curved lines I–V) in relationship to their clinical signs and symptoms ,…
The Potential Benefits of Diet and Physical Activity Among Active Surveillance Patients with Low-Burden Prostate Cancer
Name of trial (NCT No.) Start Subjects Inclusion criteria Intervention Outcomes (primary, secondary, tertiary) Feasibility Study on a Nordic Lifestyle Intervention Trial Among Men With Prostate Cancer (NCT01300104) Feb 2011…
How Does QoL Compare Between Surveillance and Active Treatment?
Authors, journal, year Country Study design Therapies and number of participants per study group Measures Number of measurements AS compared to curative treatment 1. Jeldres et al., cancer, 2015 [15]…
Gleason 6 Tumors Should Still Be Labeled as Cancer
Fig. 5.1 Recurrence-free progression following radical prostatectomy stratified by prostatectomy grade. Green line: Gleason score 6, Grade Group 1. Orange line: Gleason score 3 + 4, Grade Group 2. Dark blue line:…
Cancer Overdiagnosis and Overtreatment
Fig. 1.1 This illustrates the difference between a true epidemic of serious disease, where a rise in incidence is paralleled by an increase in mortality, and a “pseudo-epidemic” or overdiagnosis,…
The Role of Fear in Overdiagnosis and Overtreatment
© Springer International Publishing AG 2018Laurence Klotz (ed.)Active Surveillance for Localized Prostate CancerCurrent Clinical Urologyhttps://doi.org/10.1007/978-3-319-62710-6_3 3. The Role of Fear in Overdiagnosis and Overtreatment Iona Heath1 (1) Royal College of General Practitioners, London, UK …
