Can We Screen and Still Reduce Overdiagnosis?
Fig. 2.1 Scheme depicting the age-related natural history of five hypothetical forms of prostate cancer (presented by the curved lines I–V) in relationship to their clinical signs and symptoms ,…
The Potential Benefits of Diet and Physical Activity Among Active Surveillance Patients with Low-Burden Prostate Cancer
Name of trial (NCT No.) Start Subjects Inclusion criteria Intervention Outcomes (primary, secondary, tertiary) Feasibility Study on a Nordic Lifestyle Intervention Trial Among Men With Prostate Cancer (NCT01300104) Feb 2011…
How Does QoL Compare Between Surveillance and Active Treatment?
Authors, journal, year Country Study design Therapies and number of participants per study group Measures Number of measurements AS compared to curative treatment 1. Jeldres et al., cancer, 2015 [15]…
Gleason 6 Tumors Should Still Be Labeled as Cancer
Fig. 5.1 Recurrence-free progression following radical prostatectomy stratified by prostatectomy grade. Green line: Gleason score 6, Grade Group 1. Orange line: Gleason score 3 + 4, Grade Group 2. Dark blue line:…
Cancer Overdiagnosis and Overtreatment
Fig. 1.1 This illustrates the difference between a true epidemic of serious disease, where a rise in incidence is paralleled by an increase in mortality, and a “pseudo-epidemic” or overdiagnosis,…
The Role of Fear in Overdiagnosis and Overtreatment
© Springer International Publishing AG 2018Laurence Klotz (ed.)Active Surveillance for Localized Prostate CancerCurrent Clinical Urologyhttps://doi.org/10.1007/978-3-319-62710-6_3 3. The Role of Fear in Overdiagnosis and Overtreatment Iona Heath1 (1) Royal College of General Practitioners, London, UK …
Surveillance at the Margins: Management of High-Volume Gleason 6, PSA > 10, or Gleason 3 + 4
Clinical stage PSA (ng/mL) Gleason score on biopsy PSA density Number of positive cores on biopsy University of Toronto, Canada [7] T1c/T2a ≤10–15 ≤3 + 4 (1.4% of cohort were 4 + 3)…
Ethical and Legal Considerations in Active Surveillance for Prostate Cancer
© Springer International Publishing AG 2018Laurence Klotz (ed.)Active Surveillance for Localized Prostate CancerCurrent Clinical Urologyhttps://doi.org/10.1007/978-3-319-62710-6_4 4. Ethical and Legal Considerations in Active Surveillance for Prostate Cancer Lionne D. F. Venderbos1 (1) Department of Urology, Erasmus University Medical…
Biosimilars in Inflammatory Bowel Disease 2017: State of the Science, State of the Art, and State of the Finances
1. Expression system 2. Manufacturing process 3. Assessment of physiochemical properties 4. Functional activities 5. Receptor binding and immunochemical properties 6. Measurement of impurities 7. Stability under multiple stress conditions…
Noninfectious and Nonmalignant Complications of Anti-TNF Therapy
Acute infusion/injection reactions Delayed infusion/injection reactions Timing of onset Within first hours of dose 3–14 days Clinical presentation Mild: Fever, nausea, vomiting, wheal formation, pruritus, erythema Serum sickness-like syndrome:…
