Fig. 33.1 The manufacturing process of certolizumab pegol Effectiveness and Safety in Crohn’s Disease: Randomized Controlled Trials PRECISE Studies Two randomized placebo-controlled double-blind Phase III studies , PRECISE 1 and…
Fig. 30.1 Azathioprine metabolism . TPMT thiopurine-S-methyl transferase Pharmacologic Mechanism of Thiopurines 6-TGNs affect the immune response via several potential mechanisms. They are incorporated into DNA, thereby inhibiting its synthesis…
Fig. 26.1 Utility scores for Crohn’s disease versus the general population. Adapted from Rocchi 2012 Nov;26(11):811–7 Cost–Utility Analysis In cost–utility analysis [2], utility scores are converted to quality adjusted life…
Fig. 3.1 Structure of the epithelial barrier . (a) Transmission electron micrograph depicting the apical junctional complex between two mouse enterocytes. From apical to basal, the apical junctional complex consists…
T cell transfer Genetic Spontaneous Bacterial CD45RBhigh → RAG−/− (SB + C) WT → CD3εtg IL-2−/− IL-2Rα−/− IL-10−/− TCR−/− Gαi2−/− Mdr1a−/− TNFΔARE (SB) STAT3−/− STAT4 tg CD40L tg A20−/− TGFβ1−/−…
Antimicrobial Size (kDa) Antibacterial activity Cellular source α-Defensin 1–4 3.4 Gm+ and Gm− Neutrophils α-Defensin 5 3.6 Gm+ and Gm− Paneth cells α-Defensin 6 3.7 Self-assembles Forms protective nets Paneth…
Initial questions may include: Practical questions may include: What is Crohn’s disease or ulcerative colitis? Where is the nearest bathroom and will I have access to it? Is it contagious?…
Relative importance References Age < 17 years +++ [3, 110] Perianal disease ++ [8, 9] Need for steroids ++ [8, 9, 111] Ileocolonic location + [9, 112] Age <…
© Springer International Publishing AG 2017Daniel C. Baumgart (ed.)Crohn’s Disease and Ulcerative Colitis10.1007/978-3-319-33703-6_58 58. Pediatric Aspects of Inflammatory Bowel Disease Brendan Boyle1 and Jeffrey S. Hyams2, 3 (1) Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Nationwide Children’s…
Time period Important points Preconception – Establish care with multidisciplinary team: primary care physician, obstetrician, maternal–fetal specialist, gastroenterologist – Discontinue medications that may be harmful to fetus (i.e. methotrexate) – Update health care…
