Management of Gastrointestinal Stromal Tumors
Site % Gastric 60–70 Small intestine 25–33 Jejunum/ileum 27 Duodenum 5 Rectum 3–10 Large intestine 3–5 Esophagus <1 Other intra-abdominal 8 Extra-abdominal <5 GIST tends to be quite friable and…
Site % Gastric 60–70 Small intestine 25–33 Jejunum/ileum 27 Duodenum 5 Rectum 3–10 Large intestine 3–5 Esophagus <1 Other intra-abdominal 8 Extra-abdominal <5 GIST tends to be quite friable and…
Fig. 1 Duodenal gastrointestinal stromal tumor with overlying normal mucosa Fig. 2 Gastrointestinal stromal tumor with overlying ulcers in the proximal gastric body 5.2 Endoscopic Ultrasonography Standard endoscopy provides imaging…
Fig. 1 Port placement and patient positioning for laparoscopic wedge resection [10] 2.2 Laparoendoscopic Technique This technique, as previously described [19], is for patients with predominantly intraluminal masses. Positioning is…
Fig. 1 CT characteristics of GISTs. (a) Polypoid gastric GIST (arrow), (b) Exophytic gastric GIST (c) Exophytic small bowel GIST fistulizing to the bowel lumen note the contrast within the…
Fig. 1 Surgical palliation refers to the use of a procedure with the intention of relieving symptoms, minimizing patient distress, increasing the durability of treatment, improving quality of life, decreasing…
Fig. 1 CT scans in a patient with gastroesophageal junction GIST (red circle) before (a) and after (b) 3 months of neoadjuvant imatinib, showing partial response Fig. 2 PET scans…
GIST location N Progression rate with full long-term follow-up Size <5 cm Size <5 cm Size >10 cm Size >10 cm <5 mitoses per 50 HPFs >5 mitoses per 50…
Author, Year Patients TKI R0/R1 rate Recurrence/PFS Survival Predictors Raut (2006) [68] 23 SD/PR 32 localized progression 14 generalized progression All SD/PR: 78 % LP: 25 % GP: 7 %…
© Springer International Publishing Switzerland 2017Charles R. Scoggins, Chandrajit P. Raut and John T. Mullen (eds.)Gastrointestinal Stromal Tumors10.1007/978-3-319-42632-7_13 Advances on Molecular Characterization and Targeted Therapies on GIST Gabriel Tinoco1, Guozhi Hu1, Ana Paz-Mejía1 and Jonathan Trent1 (1) Department of…