Pediatric Issues in Treating Ulcerative Colitis
Item Points 1. Abdominal pain No pain 0 Pain can be ignored 5 Pain cannot be ignored 10 2. Rectal bleeding None 0 Small amount only, in less than 50…
Pregnancy and Fertility in Ulcerative Colitis
Medication FDA pregnancy categorya Pregnancy Breastfeeding Recommendation Recommendation 5-ASA Sulfasalazine B Low risk, replace folate daily Probably compatible, possible diarrhea Mesalaminea B Low risk Probably compatible, possible diarrhea Ca Asacola—phthalate…
Treatment of Severe Ulcerative Colitis
© Springer Science+Business Media New York 2014Gary R. Lichtenstein (ed.)Medical Therapy of Ulcerative Colitis10.1007/978-1-4939-1677-1_23 23. Treatment of Severe Ulcerative Colitis Seamus J. Murphy1 and Asher Kornbluth2 (1) Department of Medicine, Daisy Hill Hospital, 5 Hospital Road, Newry,…
Disease Modifiers in the Management of Ulcerative Colitis
Antibiotics • No definitive cause between early use and IBD • Most studied include tetracyclines, penicillin Oral contraceptives • Weak association with CD that increases with length of exposure • Risk reverts to nonexposed…
Rectal Glucocorticoid Use in Ulcerative Colitis
Systemic Hydrocortisone (in alcohol or as a hemisuccinate sodium) Prednisolone-21 phosphate Betamethasone Nonsystemic steroids Prednisolone metasulfobenzoate Beclomethasone dipropionate Budesonide Glucocorticoids Mechanisms of Action Glucocorticoid activity is dependent on specific glucocorticoid…
Novel Nonbiologic Therapies for Ulcerative Colitis
20. Baumgart DC. Extended colonic release low-molecular weight heparin (LMWH) not ready for use in ulcerative colitis. Evid Based Med. 2011;16:71–2.PubMed 21. Tytgat GN, Van Nueten L, Van De Velde…
Probiotics, Prebiotics, and Antibiotics for Ulcerative Colitis
Author Ref. Maintenance or induction of remission Probiotic Comparator Study duration UC population Primary clinical outcome Results Treatment arm Control arm(s) Tursi et al. [49] Induction of remission VSL#3 + balsalazide Balsalazide…
Beyond Infliximab: Other Anti-TNF Therapies for Ulcerative Colitis
Clinical trials ACT1/ACT2 ULTRA1/ULTRA2 PURSUIT-SC Placebo (n = 121/123) IFX 5 mg/kg (n = 121/121) IFX 10 mg/kg (n = 122/120) Placebo (n = 130/246) ADA 80/40 (n = 130/–) ADA 160/80 (n = 130/248) Placebo (n = 331) GLM 100/50 (n = 72) GLM 200/100…
The Role of the Food and Drug Administration in Medical Therapy for Ulcerative Colitis
Drug FDA approval FDA-approved indication in ulcerative colitis Prednisolone 1972 To tide the patient over a critical period of the disease in ulcerative colitis Sulfasalazine 1977 Treatment of mild to…
Infliximab for Ulcerative Colitis
Fig. 15.1 Mucosal healing 14 weeks after introduction of infliximab. Endoscopic images of the sigmoid at baseline (upper panel) and at week 14 (lower panel) in a patient receiving infliximab…
