Total Pancreatectomy



Total Pancreatectomy


Michael L. Kendrick

Michael B. Farnell



Introduction

Total pancreatectomy (TP) in both benign and malignant pancreatic disease remains an acceptable alternative in selected patients. Whereas the significant operative sequela and morbidity of this procedure has limited general enthusiasm, increasingly aggressive diabetic management, pancreatic enzyme replacement, surgical techniques, and auto islet cell transplantation continue to spark interest for TP.

In theory, a more radical operation would be expected to provide a more favorable outcome with regard to disease such as intractable pain from chronic pancreatitis or disease free survival after resection of malignancy. In practice, however, superior outcomes have not been consistently demonstrated in cohort studies and Level I evidence does not exist. The treatment of intractable pain in patients with chronic pancreatitis, recurrent acute pancreatitis, and pancreatic malignancy, remains challenging with either medical or surgical approaches and the search for methods to improve outcomes continues. In selected patients, TP appears to be a valid and occasionally necessary alternative and indications may be expanding. Several series have demonstrated increasingly favorable outcomes of TP with appropriate patient selection, surgical technique, and postoperative care.

The potential advantages of TP include:



  • Elimination of pancreatic leak from the pancreatic remnant observed after partial pancreatectomy.


  • Amelioration or elimination of intractable pain in recurrent or chronic pancreatitis.


  • Elimination of recurrent disease such as pancreatitis or intraductal papillary mucinous neoplasm (IPMN).


  • Avoidance of parenchymal transection with potential tumor spillage in malignancy.


  • Negates the need for surveillance imaging for potentially recurrent disease of the remnant pancreas.

Disadvantages of TP include complete pancreatic exocrine and endocrine insufficiency as well as the morbidity of the procedure itself. Diabetes after TP may result in considerable morbidity as “brittle diabetes” sets the stage for difficult diabetic management where readmission for hypoglycemic episodes and suboptimal nutrition are not uncommon. With the lack of a pancreatic anastomosis, one would also expect reduced perioperative morbidity compared to partial pancreatectomy. In most series, however,
morbidity after TP ranges from 40% to 60% and is comparable to that observed in partial pancreatectomy and historically, mortality has been higher than for pancreaticoduodenectomy.








TABLE 7.1 Possible Indications for Total Pancreatectomy







  • Chronic pancreatitis with intractable pain or recurrent acute pancreatitis



  • Hereditary pancreatitis



  • Diffuse main-duct intraductal papillary mucinous neoplasm



  • Diffuse branch-duct intraductal papillary mucinous neoplasm



  • Recurrent pancreatic neoplasm after partial pancreatectomy



  • Intrapancreatic extension of localized pancreatic malignancy preventing R0 resection with partial pancreatectomy



  • Technical factors or intraoperative complications after partial pancreatectomy




PREOPERATIVE PLANNING

Patients with indications for TP should be screened for prohibitive comorbidities and have an appropriate cardiopulmonary evaluation based on a thorough history and physical examination. Existing comorbidities such as hypertension, diabetes, and cardiopulmonary conditions should be adequately assessed and optimized prior to TP. Appropriate selection of patients for TP also includes assessment of the patient’s ability to comprehend the implications of complete pancreatic endocrine and exocrine insufficiency, and ability to follow the nutritional recommendations and comply with necessary treatment. Ideally, the patient should receive diabetes education preoperatively which facilitates the assessment of patient understanding, may identify compliance issues and enhances the education process in the postoperative period. The patient should also be vaccinated against common encapsulated bacteria (Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria Meningitidis) 2 weeks preoperatively when splenectomy is anticipated and should be educated regarding the entity of postsplenectomy sepsis. The anesthesiologist should be alerted to the need for intraoperative glucose monitoring and continuous infusion of insulin. Prophylactic (<24 hours) antibiotics and deep venous thrombosis prophylaxis are used routinely.



SURGICAL TECHNIQUE


Positioning and Exposure

The patient is positioned supine with arms padded and tucked at their side (preferred) or at 90 degrees. A fixed retractor is positioned to allow bilateral cephalad retraction of the costal margins.

An initial right subcostal or limited upper midline incision is made. A thorough exploration is performed focusing on all peritoneal and visceral surfaces. In the absence of metastatic disease, the subcostal incision is extended to the left. The subcostal retractors are placed and secured to the frame of the fixed retraction system chosen. To maximize the exposure, the inferior abdominal wall flap is secured with a heavy suture to the inferior abdominal wall. Initial dissection is performed to identify evidence of any local findings that would preclude resection. Mobilization of the hepatic flexure of the colon optimizes exposure for kocherization and the eventual distal duodenal dissection. A full kocherization of the duodenum is then performed, extending medially to the aorta (Fig. 7.1). This maneuver allows assessment of the pancreatic head and exclusion of retroperitoneal extension of inflammation or tumor. The left hand is placed around the pancreatic head and the tips of the fingers assess for involvement of the superior mesenteric artery (SMA). In the current era of improved CT imaging, these maneuvers will rarely identify evidence of local unresectability, however, they optimize initial exposure and allow improved control needed during dissection of the superior mesenteric and portal vein. Careful inspection of the lesser sac is performed to exclude peritoneal metastases and assess for adjacent organ involvement by inflammation or malignancy. The omentum is dissected off the transverse colon in the avascular plane and the lesser sac is widely exposed (Fig. 7.2). With the anterior surface of the pancreas exposed, the avascular attachments between the stomach and pancreas are divided. The middle colic vein is followed to the superior mesenteric vein (SMV) and the gastrocolic venous trunk is identified, ligated, and divided (Fig. 7.3A). This allows safe exposure of the SMV and the inferior border of the pancreas. The middle colic vein is occasionally divided on the basis of necessary exposure or suspected proximity to tumor. Retraction of the colon inferiorly without division of the gastrocolic trunk can lead to inadvertent avulsion and

bleeding. If bleeding is encountered during dissection or ligation of the gastrocolic trunk, the left hand placed posterior to the pancreatic head with the thumb anteriorly will allow direct compression of the SMV to control hemorrhage and facilitate venorrhaphy.






Figure 7.1 The hepatic flexure of the right colon is released inferiorly to aid in performing a Kocher maneuver, which elevates the duodenum and the head of the pancreas (view from right lateral side of the patient). IVC, inferior vena cava. Adapted from illustrations by David Factor from “The Role of Total Pancreatectomy in the Treatment of Pancreatic Cancer” Pancreatic Cancer, edited by Von Hoff, Evans and Hruban, 2005. By permission of Mayo Foundation for Medical Education and Research. All rights reserved.






Figure 7.2 The lesser sac is entered by freeing the greater omentum off the transverse colon. Adapted from illustrations by David Factor from “The Role of Total Pancreatectomy in the Treatment of Pancreatic Cancer” Pancreatic Cancer, edited by Von Hoff, Evans and Hruban, 2005. By permission of Mayo Foundation for Medical Education and Research. All rights reserved.






Figure 7.3 (A) The anterior and lateral exposure to the superior mesenteric vein is facilitated by ligation of the gastrocolic venous trunk. (B) Careful dissection with a blunt clamp anterior to the superior mesenteric vein/portal vein confluence aids in assessing the relationship of the neck of the pancreas to the vein (view from right lateral side of the patient). Adapted from illustrations by David Factor from “The Role of Total Pancreatectomy in the Treatment of Pancreatic Cancer” Pancreatic Cancer, edited by Von Hoff, Evans and Hruban, 2005. By permission of Mayo Foundation for Medical Education and Research. All rights reserved.

With the gastrocolic trunk divided, the SMV can easily be followed to the inferior border of the pancreas. A curved, blunt clamp is used to develop the plane between the SMV and the posterior aspect of the pancreatic neck (Fig. 7.3B). The clamp should advance easily. Difficulty in passing the clamp posterior to the neck of the pancreas should prompt consideration of malignant invasion or significant inflammatory involvement of the superior mesenteric or portal vein. After an initial assessment of the pancreatic neck from the inferior approach, assessment at the superior aspect is performed. The gastrohepatic ligament is incised and the right gastric artery ligated and divided (Fig. 7.4A). The common hepatic artery is dissected at the
superior border of the pancreatic neck and the consistent lymph node in this region is excised. This allows excellent exposure of the origin of the gastroduodenal artery and the insertion of the coronary vein. Ligation and division of the gastroduodenal artery is performed (Fig. 7.4B). Careful dissection at the inferior border of the common hepatic artery near the origin of the gastroduodenal artery will identify the portal vein (Fig. 7.4C). From an inferior approach, a clamp is now advanced anterior to the SMV with the tip oriented in the same direction as the exposed portal vein. Care should be taken to avoid veering to the medial aspect of the vein, as inadvertent injury to the insertion of the coronary vein or splenic vein can occur. A cloth “tape” is passed around the neck of the pancreas which facilitates exposure and retraction of the pancreas (Fig. 7.4D).






Figure 7.4 (A) Placement of inferior traction on the lesser curvature of the stomach allows incision of the gastrohepatic ligament and exposure and ligation of the right gastric artery. (B) Inferior traction on the neck of the pancreas allows for optimal dissection and ligation of the gastroduodenal artery. An accessory or replaced right hepatic artery can be seen or palpated posterior to the common bile duct. (C) Superior retraction of the common hepatic artery allows exposure of the anterior surface of the portal vein as well as identification of the coronary vein. (D) A tape is passed around the neck of the pancreas (view from right lateral side of patient). Adapted from illustrations by David Factor from “The Role of Total Pancreatectomy in the Treatment of Pancreatic Cancer” Pancreatic Cancer, edited by Von Hoff, Evans and Hruban, 2005. By permission of Mayo Foundation for Medical Education and Research. All rights reserved.






Figure 7.5 The transverse mesocolon is retracted in an inferior direction as the peritoneum at the inferior border of the pancreas is incised. The inferior mesenteric vein is identified and at this stage preserved. Adapted from illustrations by David Factor from “The Role of Total Pancreatectomy in the Treatment of Pancreatic Cancer” Pancreatic Cancer, edited by Von Hoff, Evans and Hruban, 2005. By permission of Mayo Foundation for Medical Education and Research. All rights reserved.

Jun 15, 2016 | Posted by in HEPATOPANCREATOBILIARY | Comments Off on Total Pancreatectomy

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