Essentials of Diagnosis
General Considerations
Many patients present to emergency departments or physician offices with very elevated BPs, but few of these involve either hypertensive emergencies or urgencies. True hypertensive emergencies occur in only one to two people per 100,000 population per year in developed countries, but may be up to four times more common in developing nations, minority populations, economically challenged individuals, and those who are nonadherent to prescribed antihypertensive drugs. To triage such patients appropriately it is important to identify symptoms or signs indicating acute, ongoing target-organ damage. This can take several forms, but usually involves the central nervous system (including the optic fundi), cardiovascular system, kidneys, and/or uterus (see the first three columns of Table 45–1). Patients with acute, ongoing target-organ damage are at very high risk of cardiovascular events and generally should be treated within minutes in a heavily monitored setting with a short-acting intravenously delivered antihypertensive agent (typically sodium nitroprusside). Individuals who do not have acute, ongoing target-organ damage may be referred to a source of ongoing care for hypertension (if at low risk), or treated with orally administered antihypertensive agents (if at moderate risk) and the BP response observed.
Type of emergency | Symptoms and signs | Other findings | Recommended drug | Blood pressure target |
---|---|---|---|---|
Neurologic emergencies | ||||
Hypertensive encephalopathy (typically a diagnosis of exclusion) | Mental status changes, generally without focal neurologic signs; papilledema is common | No other findings to explain mental status changes | Nitroprusside1 | 25% reduction over 2–3 hours |
Acute ischemic stroke | Focal neurologic signs, headache | CT or MRI may show infarcted or ischemic area | Nitroprusside1 (controversial) | Blood pressure is generally not treated unless it is higher than 180–220/110–120 mm Hg |
Intracranial hemorrhage | Headache, focal neurologic signs | CT or MRI typically shows hemorrhagic area | Nitroprusside1 (controversial) | 0–25% reduction over 6–12 hours (controversial) |
Subarachnoid hemorrhage | Headache | Lumbar puncture shows xanthochromia and/or blood | Nimodipine | Up to 25% reduction in previously hypertensive patients, 130–160 mm Hg systolic for normotensive patients |
Acute head injury/trauma | Headache, signs of external trauma | CT or MRI may show area of traumatized brain | Nitroprusside1 | 0–25% reduction over 2–3 hours (controversial) |
Cardiovascular emergencies | ||||
Acute myocardial infarction | Chest discomfort, dyspnea, anxiety | Electrocardiogram may show hyperacute T-wave elevation; troponin is typically elevated | Nitroglycerin | Cessation of ischemia (typically only a 5–10% decrease is required) |
Acute left ventricular failure/acute pulmonary edema | Dyspnea, pulmonary rales |