Title

Author

Journal

Year

Time period

Testicular CA

Mortality

Prognostic factors

Survivals

Additional points

Hepatic resection for disseminated germ cell carcinoma

Goulet et al. [15]

Annals of Surgery

1990

1976–1989

28

0 %

54 % in the last 5 years

Hepatic resection for noncolorectal nonneuroendocrine metastases: a 15-year experience with 96 patients

Harrison et al. [16]

Surgery

1997

1980–1995

34 GU 9 testicular

0 %

Disease-free interval, R0, primary tumor site

GU tumors have a 60 % 5-year survival

Comparison of histological results from the resection of residual masses at different sites after chemotherapy for metastatic non-seminomatous germ cell tumors

Hartmann et al. [17]

European Journal of Cancer

1997

1980–1995

4

0 %

R0 resection, necrosis/mature teratoma on histology associated with improved disease-free and overall survival

73 % alive after 33 months

30 % had dissimilar histologic findings. 27 patients were eligible (2 sites of resection)

Resection of liver metastases from a noncolorectal primary: indications and results based on 147 monocentric patients

Elias et al. [18]

Journal of the American College of Surgeons

1998

1984–1996

20

2 %

36 %

50 % 3-year survival for testicular CA. 46 % 5-year survival. No difference between curative and palliative resection. Neuroendocrine tumors included in study

Hepatic resection of metastatic testicular carcinoma: a further update

Hahn et al. [19]

Annals of Surgical Oncology

1999

1974–1996

57

0 %

Group 1 and 2

Group 1: 8/9 alive, Group 2 23/29, Group 3a 6/14, Group 3b 2/5

Group 1 had necrosis on pathology; group 2 showed a mature teratoma; 3a had active disease with normal preop tumor markers; 3b had elevated preop markers

Hepatic resection for noncolorectal nonendocrine liver metastasis

Hemming et al. [20]

Liver Transplantation

2000

1978–1998

1

0 %

Primary tumor (GI vs non-GI) and R0 resection

45 %

Most were in the right hemiliver

Resection of noncolorectal and nonendocrine liver metastases: late metastases are the only chance of cure

Laurent et al. [21]

World Journal of Surgery

2001

1980–1997

2

0 %

Disease-free interval >24 months, GU primary

35 %

Encouraged re-hepatectomy

Multimodality treatment of patients with liver metastases from germ cell tumors. The role of surgery

Rivoire et al. [22]

Cancer

2001

1984–1997

37

3 %

Tumor less than 10 mm. Poor outcome associated with lesions greater than 30 mm, presence of viable disease or embryonal CA

62 %

18 had necrosis, 7 had mature teratoma, and 12 had active disease

Partial hepatectomy for metastases from noncolorectal nonneuroendocrine carcinoma

Weitz et al. [23]

Annals of Surgery

2005

1981–2002

20

0 %

Disease-free interval >24 months, reproductive tract primary, R0 resection

72 % 3-year survival

Role of postchemotherapy surgery in the management of patients with liver metastases from germ cell tumors

Hartmann et al. [24]

Annals of Surgery

2005

1990–1998

43

0 %

Refractoriness to chemo was associated with a shorter survival, and a trend was established with elevated AFP

70.9 %

Necrosis in 67 %, teratoma in 12 %, and cancer in 21 %. Histologic discrepancy in 39 %

Hepatic resection for noncolorectal nonendocrine liver metastases

Adam et al. [14]

Annals of Surgery

2006

1983–2004

78

2.3 %

Limited resection, R0, disease-free interval, younger age, response to chemotherapy

36 %

Mortality was over 60 days. Repeat hepatectomy has benefit 69 % vs 33 %

Long-term results of liver resection for non-colorectal, nonneuroendocrine metastases

O’Rouke et al. [25]

Annals of Surgical Oncology

2007

1986–2006

1

0.8 %

Tumor size less than 5 cm in diameter, absence of extrahepatic disease/nodal disease and R0 resection had better outcomes – univariate analysis

38.5 %

Review of 2 prospective databases. Diameter greater than 5 cm and extrahepatic nodal disease were the only two positive variables on multivariate analysis