Other laboratory investigations include renal function studies (creatinine, urea, and electrolytes including magnesium and phosphate), PTH, serum 1, 25-dihydroxyvitamin D, and immunoreactive PTH (iPTH).
Management
Hydration with intravenous normal saline is the mainstay of treatment together with frusemide (not thiazides). Intravenous bisphosphonates (pamidronate) is indicated if there is lack of response to hydration, very high calcium levels, obtundation or severe symptoms. Patients with renal failure may need dialysis.
Calcitonin is a very expensive option; it works very quickly but exhibits tachyphylaxis.
Post-operative Emergencies
Treatment of urogenital malignancy often involves major surgical procedures (e.g. radical prostatectomy, cystoprostatectomy and nephrectomy). As the incidence of many urological cancers increase with advancing age, surgery is being considered for a growing number of older patients often with multiple co-morbidities and less able to cope with post-operative complications. Some of these patients may well be nursed in high dependency units as indicated. An understanding of the common post-operative emergencies related to the surgical procedure is essential for satisfactory perioperative management and achieving good outcomes.
Bleeding
Pelvic surgery may be associated with major blood loss. Postoperative monitoring of vital signs and early recognition of ongoing blood loss is essential. Warning signs (apart from haemodynamic instability) include high drainage output, poor perfusion, low urine output despite adequate intraoperative fluid replacement. Correction of coagulopathy is important especially if there has been significant intraoperative transfusion requirement.
Visceral injuries: Leakage due to bowel injury or urinary leak from anastomosis (vesico-urethral) is the most dreaded complication of abdominal urological surgery. The first important aspect is to recognise and correct it if possible. Initial postoperative observation will help to detect such problem early.
Sepsis
This is associated with significant morbidity and mortality especially in the elderly patient. Common causes for postoperative fever include pulmonary atelectasis and catheter/line associated infections. Specific causes related to uro-oncological surgery include
Wound infection
Infected deep- seated collections (e.g. pelvic lymphocoele, haematoma)
Urinoma (leakage from uretero-intestinal anastomosis, veisco-urethral anastomosis after pelvic surgery or renal collecting system following partial nephrectomy)
It is important to remember that an infected collection requires urgent surgical or radiological drainage rather than prolonged antibiotic therapy
Peritonitis -This may occur from leakage from an intestinal anastomosis (e.g. Following cystectomy and urinary diversion) or inadvertent injury to bowel during open or laparoscopic surgery and usually require surgical exploration
References
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