Robot-Assisted Retroperitoneal Lymphadenectomy


Series

Year of publication

Number of cases

Primary vs. secondary RPLND

Minor complications (Clavien < 3)

Major complication (Clavien ≥ 3)

Cheney et al. [1]

2015

18

Both

17%

0%

Harris et al. [2]

2015

16

Primary

0%

6.3%

Stepanian et al. [3]

2016

20

Both

Not reported

5%

Pearce et al. [4]

2016

42

Primary

4.7%

4.7%



The objective of this chapter is to describe potential complications, highlight associated risk factors, and discuss the prevention and management of each one of these potential complications. This will be described in a stepwise fashion depending on the step at which respective complication may arise and will be preceded by a brief description of the surgical technique.



Preoperative Considerations



Anesthetic Risks and Preoperative Evaluation


The majority of the patients who undergo this procedure are young and otherwise healthy and can be prepared with a routine preoperative anesthetic evaluation. However, special attention should be paid to patients who had previously received chemotherapy, which commonly includes bleomycin. Although symptomatic pulmonary fibrosis most commonly takes place in elderly patients who receive this treatment, younger patients may have subtle subclinical changes. Bleomycin is responsible for the development of interstitial pneumonitis and deposition of extracellular matrix protein in alveolar wall resulting in restrictive lung disease. The effect of bleomycin is dose-dependent and may be exaggerated in patients who have other pulmonary risk factors such as smoking, asbestos exposure, etc. Symptoms of bleomycin pulmonary toxicity include cough, shortness of breath, tachypnea cyanosis, and fever. However, screening for these symptoms is not always enough as most patients are asymptomatic. It is very important to realize that bleomycin pulmonary toxicity is symptomatic in only 20% of patients and thus a high index of suspicion should be kept in mind. Preoperative assessment of pulmonary function with a pulmonary function test is necessary for preoperative planning [57]. Specific parameters include diffusion capacity for carbon dioxide or partial pressure of arterial oxygen, which may be a good prognosticator for anesthetic complications and death. Fatality in these cases is thought to be due to the development of adult respiratory distress syndrome which in turn takes place secondary to oxygen toxicity and fluid overload during anesthesia. The lowest possible supplemental O2 concentration should be used intraoperatively to maintain acceptable oxygenation as these patients are more sensitive to O2 pulmonary toxicity [8]. Furthermore, intraoperative fluid replacement in these cases should be kept to a minimum to avoid pulmonary edema, which is often mistakenly treated by increasing oxygen supplementation that leads to further pulmonary toxicity. Fluid replacement is preferably performed with alternation between colloids and crystalloids.


Risk of Bleeding and Thrombosis


Any therapeutic anticoagulation with long-acting agents should be discontinued appropriately. Blood type and screen is routinely ordered prior to the surgery whereas cross-matching is obtained only when the likelihood of significant bleeding is high, such as when a large retroperitoneal mass is seen on preoperative imaging or in post-chemotherapy patients [9]. Standard preoperative mechanical and medical deep venous prophylaxis is advised, as these patients have multiple risk factors to develop deep venous thrombosis. These factors include the presence of cancer, need for vascular dissection, and prolonged time of pneumoperitoneum. The prophylaxis can be achieved by 5000 IU of subcutaneous heparin or 30–40 mg of lovenox, as well as the use of knee level elastic stockings and sequential pneumatic compression devices. Prophylaxis should be continued throughout the hospital stay and in some cases may be continued in the postoperative setting when appropriate [10].


Bowel Preparation


The authors do not routinely use any specific bowel preparation unless the suspicion of bowel injury is high. A bowel preparation with one bottle of magnesium citrate can be given depending on surgeon preference and patients can be asked to adhere to a clear liquid diet the day before surgery. An orogastric or nasogastric tube can be inserted at time of induction and removed at the end of the case for the same reason. Although prolonged postoperative ileus is rare in cases performed robotically, if there is a high likelihood of conversion preoperative administration of μ opioid receptor antagonist (alvimopan) can potentially shorten the duration of ileus. It is not the practice of the authors to use this routinely in RPLND but this can be potentially helpful in patients anticipated to have a prolonged ileus.


Antibiotic Prophylaxis


Unless an inadvertent injury to the bowel or the urinary system takes place, RARPLND results in Class I (clean) wound. Standard parenteral broad-spectrum antibiotic such as cefazolin is given 30 min prior to incision and repeated dosing is administered based on the length of the procedure [11]. However, no postoperative antibiotic is routinely required.


Preparation for Vascular Emergencies


Although vascular emergencies are not common in RARPLND, the whole surgical team should be ready for urgent, open conversion and open surgical instruments should be available inside the operating room especially early in one’s experience. Open instruments to have immediately available should include a vascular set and appropriate retractors. The console should be placed inside the operating room itself rather than in a remote location outside the operating room in order to ensure direct and clear communication. The console surgeon should be ready to switch to laparoscopy or open surgery if needed. Prevention and management of vascular emergencies are discussed in detail later in this chapter.


Positioning-Related Complications


Proper and safe patient positioning is of extreme importance in RARPLND. Most of these cases place the patient in a nonphysiological body position and sometimes require long operative times especially in post-chemotherapy patients. The patient is placed in low lithotomy, maximal Trendelenburg position and in some cases the left shoulder is tilted to the left slightly (approximately 30°), as shown in Fig. 23.1. Placing the patient in this position will facilitate exposure as gravity will retract the bowel to the left upper quadrant of the abdomen. The patient should be secured to the table using 3 in. silk tape across the chest. All potential pressure points should be padded. The head should be secured in a neutral position with a head rest on the left side in order to avoid neck flexion once the patient is tilted. Arms are tucked by the sides and the legs are spread and fixed. The peroneal nerve is prone to compression and the surgical team should try to have the legs relatively extended without full extension. In most cases, standard Trendelenburg that is used for robotic pelvic procedures is all that is needed.

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Fig. 23.1
Patient positioning . Please note the position of the left leg is slightly lower and more extended compared to the right leg to avoid clashing with the robotic arm

Neurapraxia is one of the most commonly encountered complications after any procedure with extreme positioning and is usually self-limiting and resolves with conservative management and physical therapy [12]. Early in one’s experience, the procedures may be long and being aware of the time the patient is in extreme positioning is critical. Complications such as rhabdomyolysis are of significant concern when the patient is in extreme positioning greater than 4–6 h. Patients should be assessed in the recovery room once they are fully awake where a vigilant neurovascular examination of the extremities can be conducted. Early detection and treatment of ischemia is important to prevent consequences of this complication . Follow-up of immediate postoperative labs, physical exam, and urine output will unveil any signs of rhabdomyolysis, which can be treated with aggressive hydration [13]. If rhabdomyolysis is suspected, the extremities should be assessed with compartment pressures and consultation to orthopedics or plastic surgery.


Access-Related Complications


As in any laparoscopic intervention , visceral injuries can take place during access or trocar placement and standard measures should be taken to avoid these injuries [14]. In RARPLND, the pneumoperitoneum is established using either a Veress needle technique or a Hasson technique if intraabdominal adhesions are expected from previous surgery. This can be performed while the patient is still in a neutral position. However, trocar placement is best performed after changing to Trendelenburg position to move the bowel away and minimize the chances of injury. The trocar location varies based on surgical preference and several approaches have been described based on the template of dissection. However, when a full bilateral template is planned, we usually use the following template (Fig. 23.2). As the midline camera port is below the umbilicus, the bladder should be maximally drained with a catheter-tipped syringe prior to trocar placement.

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Fig. 23.2
Port template for robot-assisted retroperitoneal lymph node dissection


Bowel Retraction and Suspension Stitches


An orogastric tube is inserted to completely deflate the stomach. A urethral catheter should be inserted to monitor urine output and to deflate the bladder. The bladder should be actively drained as mentioned previously. One of the most helpful maneuvers that were developed during the evolution of this technique is the bowel retraction sutures. Once the robot is docked, the bowel is retracted toward the upper abdomen and a wide incision is made in the posterior peritoneum below the bifurcation of the great vessels. This incision is the same one that is performed during open RPLND and is started caudal to the cecum and appendix and extended medially to the root of the small bowel mesentery. The peritoneum is then lifted off the underlying great vessels and space is dissected as superiorly as possible. This will be done by lifting the peritoneum with the left hand and blunt dissection will be done with the back of the scissors on the right hand. It should be noted that the inferior mesenteric artery (IMA) can be divided with impunity without any sequelae in this young group of patients if this will facilitate paraaortic dissection. Ligation of the IMA is usually done in post-chemotherapy cases in order to perform a thorough paraaortic dissection; it greatly facilitates the mobilization of the peritoneum and retraction of the bowel and mesentery [15]. The free edge of the peritoneum is then sutured to the anterior abdominal wall at multiple locations using 0 polyglactin suture on a curved needle (Fig. 23.3). This will help keep the bowel retracted in the upper abdomen and prevent its falling into the surgical field during later dissection, as shown in (Fig. 23.4). Care should be taken to avoid injury to the bowel and the epigastric vessels when these sutures are placed. A small abdominal lap sponge (“baby lap” – “e-tape”) should be inserted and used to pack the uppermost part of the retroperitoneum where the duodenum is commonly encountered to avoid injury to the duodenum during retraction. This is very important since there will be anterior retraction on the posterior aspect of the duodenum and it will prevent serosal injury. The duodenum is very susceptible to injury from minimal traction and only sharp dissection should be used when dissecting around it.

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Fig. 23.3
Suspension stitch placement


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Fig. 23.4
Retroperitoneal retraction using multiple suspension stitches

Although not a common complication in RARPLND, bowel injuries can still occur and is a devastating complication. One should be careful with electrocautery application near the peritoneum and off-field movements as energy may be transmitted and result in delayed bowel injury. In long cases, the bowel frequently slides back into the field in the left lower quadrant and surgeon should ensure that the bowel is adequately retracted whenever this happen again. The bowel retraction/suspension stitches should help prevent these complications.


Vascular Dissection


Meticulous examination of preoperative cross-sectional imaging is important to ensure absence of congenital anomalies of the blood vessels or urinary system such as accessory renal vessels or duplicated urinary systems. Most commonly encountered vascular anomalies include lower pole renal accessary vessels. The location and size of the retroperitoneal lymph nodes/masses should be taken in consideration to plan dissection.

It should be realized that intraoperative vascular injuries (especially venous) injuries are not uncommonly encountered in post-chemotherapy RARPLND and the surgeon should be competent in achieving vascular control robotically. Moreover, it is of great benefit to have an experienced laparoscopic surgeon to assist at the bedside to help temporize and control any bleeders in case of conversion to open. Most common bleeders are small veins that can be almost always controlled. In our experience, the most commonly encountered bleeders are lumbar veins and a small vein that commonly arises from the anterior surface of the IVC just above its bifurcation. During all the steps of vascular dissection the principles of vascular proximal and distal control with a vessel loop should be considered as early as possible to promptly control bleeding. Once the IVC is circumferentially dissected, a vessel loop can be passed around it twice and a Hem-o-lock® is applied at the free end the loop. This will fix the loop in place. If bleeding is encountered in that vessel, the loop can be used to control the vessel. This is most commonly performed on the IVC and allows for retraction of the IVC and exposure of the posterior structures (Fig. 23.5).
Jan 26, 2018 | Posted by in UROLOGY | Comments Off on Robot-Assisted Retroperitoneal Lymphadenectomy

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