Duodenal pseudolipomatosis histologically resembles pseudolipomatosis in the colon and stomach. Numerous clear, rounded, PAS-negative, variably sized vacuoles are present in the lamina propria. These vacuoles can cause expansion of the lamina propria with villous widening and separation of the crypts and Brunner glands (651). The lesion may mimic the fatty deposits seen in Whipple disease or lymphangiectasia. The use of special stains serves to distinguish among these possibilities.