Macrophage Therapy for Liver Fibrosis and Regeneration

Fig. 2.1

Macrophage has multiple critical roles during differentiation of HPC to hepatocytes. During liver damage TWEAK expressing macrophage stimulates HPC expansion. Hepatocyte debris eating macrophage determine the fate of HPC towards hepatocytes. During this process, macrophage also contributes to the matrix regression by producing MMPs

References

Hansel MC et al. The history and use of human hepatocytes for the treatment of liver diseases: the first 100 patients. Curr Protoc Toxicol. 2014;62:14.12.1–14.12.23.CrossRef

Gupta S. Hepatocyte transplantation. J Gastroenterol Hepatol. 2002;17 Suppl 3:S287–93.CrossRefPubMed

Forbes SJ, Rosenthal N. Preparing the ground for tissue regeneration: from mechanism to therapy. Nat Med. 2014;20:857–69.CrossRefPubMed

Furuyama K et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet. 2011;43:34–41.CrossRefPubMed

Sackett SD et al. Foxl1 is a marker of bipotential hepatic progenitor cells in mice. Hepatology. 2009;49:920–9.PubMedCentralCrossRefPubMed

Espanol-Suner R et al. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology. 2012;143:1564–75.CrossRefPubMed

Yanger K et al. Adult hepatocytes are generated by self-duplication rather than stem cell differentiation. Cell Stem Cell. 2014;15:340–9.PubMedCentralCrossRefPubMed

Tarlow BD et al. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes. Cell Stem Cell. 2014;15:605–18.CrossRefPubMed

Only gold members can continue reading. Log In or Register to continue