Preoperative
Perioperative
Postoperative days 1–3
Counseling
Thoracic epidural analgesia
Daily review of discharge criteria
Minimal preoperative fasting (solid food up to 6 h? clear fluids up to 2 h)? carbohydrate loading
Prevention of hypothermia
Ileus prevention (MgO/Macrogol/lactulose)
No anxiolytic premedication
CVP monitoring (CVP\5 mmHg)
Free fluids/normal diet POD 1
No routine drainage of the peritoneal cavity
Intravenous fluids discontinued POD 1
No standard nasogastric drainage
Oral analgesia POD 1
Start intake of water and free fluids
Normal diet POD 2
Early mobilization
Removal of urinary catheter POD 2
Postoperative nausea and vomiting (PONV) prophylaxis
Stop epidural/intravenous analgesia POD 3
Antithrombotic prophylaxis
Full mobilization POD 3
Antibiotic prophylaxis
As evident, one of the factors targeted by enhanced recovery is gastrointestinal function: the employment of thoracic epidural anesthesia, early mobilization, avoidance of excessive saline, and early feeding may shorten length of postoperative ileus and promote passage of stools [9].
Furthermore, carbohydrate loading and early oral nutritional supplements may interact with laxatives to enhance gastrointestinal recovery further allowing earlier oral intake and therefore intravenous fluid discontinuation. Thanks to these principles, postoperative catabolism may be attenuated, and insulin resistance abated. Even the incidence of minor postoperative complications proved to be reduced by improved nutritional status [10].
As stated previously, the main goal of fast-track programs is to enhance functional recovery: definition of this item is based on several criteria that are defined as follows (when all of these five criteria are met, the patient is considered functionally recovered):
Adequate pain control with oral analgesics: patients rate the intensity of their current pain on a scale of 0 (“no pain”) to 10 (“worst possible pain”). A score of 1–3 is considered to be mild, 4–6 to be moderate, and 7–10 to be severe. An adequate pain control is considered when the patient rates pain 1–3 with oral analgesics only.
Independently mobile (mobile at preoperative level): in order to report the difference between pre- and postoperative level of mobility, the “ERAS Mobility Scale,” which is inferred from the “Groningen activity restriction scale” [11], was developed. The EMS utilizes ten items of basic actions to compare the level of mobility before and after surgical intervention. When the patient is able to perform 8 out of 10 items, they are independently mobile.
Tolerance of solid food: fluid and solid food intake is monitored and must be returned to normal tolerance level. Tolerance is considered to be normal when oral intake of water or normal food is resumed and continued for at least 24 h. Furthermore prophylaxis of postoperative nausea and vomiting (PONV), which obviously influences the intake, is always performed.
Normal or decreasing serum bilirubin
No intravenous fluids
25.3 Results of Fast-Track Programs in Liver Surgery
In patients undergoing colonic surgery within ERAS® program, an earlier recovery and consequently shorter hospital length of stay was registered [12, 13]. Furthermore, a reduction of postoperative morbidity in patients undergoing intestinal resection was reported too [14]. These results stimulated liver surgeons of the ERAS® group (Maastricht, Edinburgh, and Tromsö) to adapt the ERAS program to patients undergoing open liver resection. Van Dam et al. [15] prospectively collected data from 61 ERAS patients and compared them with a historical series of 100 patients: patients belonging to the first group were able to drink fluids after 4 h from surgery and eat normally on the day after the operation; furthermore, patients were independently mobile after 3 days and were therefore discharged after a median of 5 days, reducing length of stay from 8 to 6 days (25 %), without any negative effect on surgical safety. Authors even postulated that a further reduction of stay could be achievable, given the delay between functional recovery and discharge. The explanation of this delay is often linked to social problems, problems in home care support, or logistic problems.
Stoot et al. [16] investigated the additional value of laparoscopy in the context of enhanced recovery programs and reported retrospectively a further reduction in length of stay from 7 to 5 days when patients were operated laparoscopically and managed within an ERAS program, even confirming the delay between recovery and actual discharge of the patients. Furthermore the same authors reported a reduced blood loss in ERAS group that could be explained both to fast-track principles of low central venous pressure and avoidance of excessive fluid administration and to learning curve acquisition by operating surgeons.