Anorectal Abscess and Fistula


Potential space

Superior border

Anterior border

Inferior border

Posterior border

Lateral border

Medial border

Other features

Perianal space
  
Anal verge
 
Becomes continuous with the ischioanal fat

Lower portion of anal canal

Continuous with the intersphincteric space and forms the most common abscess

Ischioanal space
 
Transverse perineal muscles
 
Lower border of the gluteus maximus and sacrotuberous ligament

Obturator internus

Levator ani and external sphincter muscle

Extends from the levator ani to the perineum. If the deep postanal space becomes infected, pus can spread circumferentially via the ischioanal space and this could form a horseshoe abscess

Intersphincteric space

Rectal wall
 
Continuous with perianal space
   
Lies between the internal and external sphincters. If infected, pus can spread

circumferentially

Supralevator space

Peritoneum
 
Levator ani muscle
 
Pelvic wall

Rectal wall

The rarest abscesses form from this space. If infected, pus can spread circumferentially

Deep postanal space

Levator ani muscle
 
Anococcygeal ligament

Tip of the coccyx
  
Pus can spread circumferentially via the ischioanal space and form a horseshoe abscess








    Pathophysiology



    Etiology






    • Table 13.2 lists the etiologies of anorectal abscesses. 90 % are from nonspecific cryptoglandular suppuration.


      Table 13.2
      Etiology of anorectal abscess

















































      Nonspecific

       Cryptoglandular

      Specific

       Inflammatory bowel disease

        Crohn’s disease

        Ulcerative colitis

        Infection

        Tuberculosis

        Actinomycosis

        Lymphogranuloma venereum

       Trauma

        Impalement

        Foreign body

        Surgery

        Episiotomy

        Hemorrhoidectomy

        Prostatectomy

       Malignancy

        Carcinoma

        Leukemia

        Lymphoma

        Radiation


    • Abscesses result from obstruction of the anal glands (Park’s cryptoglandular theory published in 1961).


    • Persistence of anal gland epithelium in the tract between the crypt and the blocked duct results in fistula formation.


    • Predisposing factors for abscess formation are diarrhea and trauma from hard stool.


    • Associated factors may be anal fissures, infection of a hematoma, or Crohn’s disease.


    Classification






    • Abscesses are classified by their location within the potential anorectal spaces (Figs. 13.1 and 13.2).

      A78842_2_En_13_Fig1_HTML.gif


      Fig. 13.1
      Anorectal spaces: (a) Coronal section. (b) Sagittal section


      A78842_2_En_13_Fig2_HTML.gif


      Fig. 13.2
      Classification of anorectal abscess


    Evaluation



    Symptoms






    • Anorectal pain, swelling, and fever.


    • Gluteal pain may accompany a supralevator abscess.


    • An intersphincteric or supralevator abscess may produce severe rectal pain with urinary symptoms (dysuria, retention, inability to void).


    Physical Exam






    • On inspection, erythema, swelling, and possible fluctuation may be seen.


    • Digital exam may not be possible due to extreme pain.


    • Anoscopy and proctoscopy are avoided in the acute setting.


    • There may be no visible external manifestations despite severe rectal pain with an intersphincteric or supralevator abscess. If palpation is possible, a mass may be appreciated.


    • With a supralevator abscess, a tender mass may be palpated on rectal or vaginal exam.


    Treatment



    General Principles






    • The treatment of an anorectal abscess is prompt incision and drainage.


    • Watchful waiting with antibiotics is ineffective and may lead to a more complicated abscess with sphincter mechanism damage.


    • Delay in treatment may lead to a life-threatening necrotizing infection and death.


    Operative Management



    Incision and Drainage





    • A perianal abscess may be drained with local anesthesia. A cruciate or elliptical incision is made over the point of maximal tenderness and the edges trimmed to prevent premature closing (which could lead to recurrence). No packing is required.


    • Most ischioanal abscesses can be drained similarly to a perianal abscess, but the location of the incision should be shifted medial toward the anal side of the abscess but lateral to the external sphincter muscle (this minimizes the complexity if a fistula develops). Large abscesses or horseshoe abscesses (with the infection usually originating from the deep postanal space) often require drainage with regional or general anesthesia in the prone or left lateral position.


    • For a horseshoe abscess, a midline incision between the anus and coccyx is made and the superficial external sphincter muscle fibers are spread to enter the deep postanal space. Counter-incisions are made over each ischioanal fossa to allow drainage of the anterior extensions (Hanley procedure). The distal half of the internal sphincter may be divided to drain the gland where the infection originated (Fig. 13.3).

      A78842_2_En_13_Fig3_HTML.gif


      Fig. 13.3
      Drainage of a horseshoe abscess


    • For pain out of proportion to physical findings, an exam under anesthesia is mandatory. An intersphincteric abscess may be established by palpation of a mass or aspiration of pus in the operating room. The treatment is division of the internal anal sphincter along the length of the abscess. The wound may be marsupialized for adequate drainage.


    • A supralevator abscess may result from an upward extension of an intersphincteric or ischioanal abscess or downward extension of a pelvic abscess. If the origin is from an intersphincteric abscess, drainage is accomplished through the rectum by dividing the internal sphincter (not through the ischioanal fossa as that would result in a suprasphincteric fistula). If the origin is an ischioanal abscess, this is drained through the perianal skin (not through the rectum as that would lead to an extrasphincteric fistula) (Fig. 13.4). If the abscess is of pelvic origin, it can be drained via the area it is pointing: through the rectum, ischioanal fossa, or percutaneously via the abdominal wall.

      A78842_2_En_13_Fig4_HTML.gif


      Fig. 13.4
      Drainage of a supralevator abscess


    Catheter Drainage





    • The area of maximal tenderness is prepped and the skin around it is infiltrated with local anesthesia (injecting at the maximal point of fluctuation may preclude the local anesthesia working in that acid environment).


    • A stab incision is made as close to the external sphincter muscle as possible so the tract is as short as possible in case a fistula develops.


    • A 10–16 French soft mushroom catheter is inserted over a probe into the cavity. It typically does not need to be sutured in place.


    • The catheter is shortened to 2–3 cm outside the skin with the tip in the depth of the abscess (Fig. 13.5a, b).

      A78842_2_En_13_Fig5_HTML.gif


      Fig. 13.5
      Catheter in an abscess cavity: (a) The correct size and length of catheter. The size of the catheter should correspond to the size of the cavity. (b) When a catheter is too short. A catheter that is too short or too small could fall into the wound


    • The length of time that the catheter is left to drain the abscess cavity depends on the size of the abscess cavity, amount of granulation tissue around the catheter, and character and amount of drainage. If in doubt, it is better to leave it longer.


    Primary Fistulotomy





    • Primary fistulotomy at the time of abscess drainage is controversial.


    • A meta-analysis showed that when the fistula is identified, drainage plus primary fistulotomy decreased the rate of subsequent fistula formation (by 83 %) with no increase in incontinence.


    • Against primary fistulotomy:



      • Difficulty in finding the internal opening (as high as 66 % of the time of abscess drainage) can lead to creation of a false passage and neglect to find the main source of infection.


      • Thirty-four to fifty percent of patients with first time abscess formation will not develop a fistula after drainage.


      • The search for an internal opening converts a procedure that can be done under local anesthesia (drainage) to one that requires regional or general anesthesia.


    • Those younger than 40 years old have a significantly higher risk of developing a fistula or recurrent abscess after initial drainage of a perianal abscess.


    • Abscess recurrence is more often observed after drainage of an ischioanal abscess.


    • If the internal opening of a low transsphincteric fistula is readily apparent at the time of abscess drainage, primary fistulotomy is feasible EXCEPT in patients with Crohn’s disease, acquired immune deficiency syndrome (AIDS), advanced age, high transsphincteric fistula, and an anterior fistula (in women).


    Antibiotics





    • Antibiotics are only used as an adjunct for patients with valvular heart disease, prosthetic heart valves, extensive soft tissue cellulitis, prosthetic devices, diabetes, immunosuppression, or systemic sepsis.


    Postoperative Care






    • Postoperatively, patients are instructed to take a regular diet, bulk-forming agents, the prescribed analgesia, and sitz baths.


    • Follow-up for patients is generally 2–4 weeks after the procedure, but those with an intersphincteric or supralevator abscess may be seen sooner at about 2 weeks.


    • If catheter drainage has been done, these patients are seen about 7–10 days after catheter placement. If the cavity has closed around the catheter and the drainage ceased, the catheter is removed. Otherwise, the catheter is left in place or a smaller catheter placed.


    • In all cases, patients are observed until complete healing occurs.


    Complications



    Recurrence






    • Up to 89 % of patients after drainage of an ischioanal or intersphincteric abscess will develop a recurrent abscess or fistula.


    • Recurrence is higher in those who had a previous abscess drained.


    • Recurrence of anorectal infections may be due to missed infections in adjacent anatomic spaces, presence of an undiagnosed fistula or abscess at the initial drainage, or failure to completely drain the initial abscess.


    Extra-anal Causes






    • Extra-anal etiologies that can lead to abscess recurrence include hidradenitis suppurativa, pilonidal abscess (with downward extension), Crohn’s disease, tuberculosis, human immunodeficiency virus (HIV) infection, perianal actinomycosis, rectal duplication, lymphogranuloma venereum, trauma, foreign bodies, and perforated rectal carcinoma.


    Incontinence






    • Iatrogenic injury can lead to incontinence, which occurs with division of external sphincter muscle during drainage of a perianal or deep postanal space abscess (in a patient with borderline continence) or division of puborectalis muscle in a patient with a supralevator abscess.


    • Prolonged packing of an abscess cavity may impair continence by leading to excessive scar formation.


    • Primary fistulotomy at the time of initial abscess drainage may lead to continence disturbances while unnecessarily dividing sphincter muscle.


    Special Considerations



    Necrotizing Anorectal Infections






    • Rarely, necrotizing anorectal infections may occur and could result in death.


    • Factors associated with this are delay in diagnosis and management, virulence of the organism, bacteremia, metastatic infections, underlying medical disorders (diabetes, blood dyscrasias, heart disease, chronic renal failure, hemorrhoids, previous abscess, or fistula), obesity, and cigarette smoking.


    Symptoms and Signs


    There are two types of presentation.



    • Group one: This group demonstrates superficial infection of the surrounding tissue including necrosis of the skin, subcutaneous tissue, fascia, and/or muscle. A black spot on the skin may occur early. Perianal crepitation, erythema, skin induration, blistering, or gangrene may be present.


    • Group two: This group presents with sepsis that involves the preperitoneal or retroperitoneal spaces. The signs may be subtle such as abdominal wall induration, tenderness, or a vague mass. Fever, tachycardia, and vascular volume depletion may precede appearance of an overt infection. CT scan is an excellent diagnostic tool (it will demonstrate origin and extent of infection).


    Treatment





    • Early recognition, aggressive surgical debridement, and appropriate antibiotic administration are the most important factors to improve outcome and reduce mortality.


    • Vigorous resuscitation with invasive monitoring and respiratory and renal support is aggressively carried out (and treated).


    • Antibiotics effective against Staphylococci, Streptococci, gram-negative coliforms, Pseudomonas, Bacteroides, and Clostridium are administered intravenously. If a gram stain shows gram-positive rods, penicillin G (24–30 million units per day) and an aminoglycoside are given.



      • Tetanus toxoid is administered.


      • The goals of surgical debridement are to radically remove all nonviable tissue back to healthy tissue, halt infection progression, and alleviate systemic toxicity.


      • The skin changes may not reflect the severity of the liquefactive necrosis of the subcutaneous tissue and extensive necrosis of the underlying fascia. Reexamination under anesthesia is usually necessary to fully evaluate wounds for further debridement.


      • Vacuum-assisted closure may be helpful for healing these wounds, which may be quite extensive.


      • Colostomy is controversial, but should be considered if the sphincter muscle is grossly infected, the patient is incontinent, there is colonic or rectal perforation, or the patient is immunocompromised. A “medical colostomy” using enteral or parenteral nutrition has also been used.


      • Suprapubic urinary diversion is controversial and considered in the presence of a known urethral stricture or urinary extravasation with phlegmon.


      • Hyperbaric oxygen therapy (with 100 % oxygen via mask or endotracheal tube at 3ATM for 2 h over 1–2 treatments in patients without chronic obstructive pulmonary disease) has been advocated for patients with diffuse spreading infections and then also to promote wound healing. This does not eliminate the mandate for wide debridement of ischemic tissue.


      • High rates of mortality due to anorectal sepsis are related to extent of disease and the patient’s metabolic status at presentation. Mortality is two to three times higher in diabetics, the elderly, and patients with delayed treatment.


    Anal Infection and Hematologic Diseases




    Mar 29, 2017 | Posted by in GASTROENTEROLOGY | Comments Off on Anorectal Abscess and Fistula

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