Robotic Restorative Proctocolectomy
Meagan M. Costedio
INDICATIONS
Restorative proctocolectomy is a technique used to reestablish intestinal continuity in patients who require complete removal of the colon and rectum. The most common indications for surgery include inflammatory bowel disease (IBD), familial adenomatous polyposis (FAP), and hereditary nonpolyposis colorectal cancer (HNPCC). The most common indications for total proctocolectomy (TPC) with ileal pouch-anal anastomosis (IPAA) are ulcerative colitis (UC) refractory to medical management, inability to tolerate medications or patient preference not to be on long term medical treatment. Other indications are IBD-associated low- or high-grade dysplasia, which are associated with a 10-40% risk of cancer at the time of surgery. Total colonic Hirschsprung’s disease is an example of a congenital indication for TPC. Crohn’s colitis is a controversial indication for TPC/IPAA. In the setting of isolated colorectal Crohn’s disease, pouch retention is 70-80% at 10 years with favorable quality-of-life scores, which is acceptable if performed with appropriate counseling.
Restorative proctocolectomy is also used to treat or prevent cancers in patients with colon cancer syndromes. TPC is indicated in patients with FAP with greater than 20 rectal polyps, or rectal polyps not amenable to endoscopic resection. This surgery is recommended when the patient is able to make an informed decision as long as he or she is asymptomatic and having yearly screening; teens to early twenties. Surgery should be performed sooner for symptoms, or high-grade dysplasia noted on endoscopic biopsy. For patients with Lynch syndrome or HNPCC, restorative proctocolectomy is offered after the development of a rectal cancer with positive genetic testing or multiple first-degree relatives with associated cancers. In the absence of rectal pathology, a total abdominal colectomy (TAC) with ileorectal anastomosis is appropriate.
Restorative proctocolectomy is commonly performed in a staged manner. A one-staged approach describes a TPC/IPAA without protective diverting loop ileostomy. This approach may potentially be cautiously used in highly selected, healthy, very well-informed patients. In the two-staged approach, the TPC/IPAA is performed with a diverting loop ileostomy, which is then reversed in a second operation in the absence of complications. The three-staged approach is most commonly used in medically refractory UC, obesity, or where the diagnosis is in question. This method entails a TAC with end ileostomy, followed by a completion proctectomy ileal pouch-anal anastomosis (CP/IPAA) with diverting loop ileostomy followed by closure of the loop ileostomy. The modified two-staged approach includes the first staged TAC with end ileostomy, followed by CP/IPAA without diverting ileostomy.
Staging is at the discretion of the surgeon taking into consideration the comorbidities of the patient. Preoperative factors of malnutrition, high-dose steroid use, or failure of biologic therapy lead to a two- or three-staged approach. A diverting loop ileostomy is commonly used even in healthy patients, as the sequelae of anastomotic leakage at the pouch-anal anastomosis are significant and have permanent adverse functional consequences. If patients with UC or Crohn’s disease develop dysplasia, either low or high grade, TPC/IPAA with high ligation of all vessels is recommended. A one-staged approach may potentially be considered for patients with FAP or HNPCC who are in good health and/or patients in whom the surgical indication is dysplasia or cancer who are not immunocompromised.
The minimally invasive approach to either the colectomy or the proctectomy is associated with decreased morbidity as well as improved fecundity in female patients with IBD. Data suggest that the robotic approach may take longer and cost more, but is safe with a potential decrease in conversion to open surgery. The robot is beneficial with the proctectomy, possibly decreasing the rate of conversion to open. The new generation of equipment allows multiquadrant surgery and a robotic colectomy is possible. This approach appears to be safe to perform this operation.
CONTRAINDICATIONS
Crohn’s disease with known active small bowel and/or perianal involvement is an absolute contraindication for restorative proctocolectomy. Patients with preoperative continence issues should have extensive counseling and consider permanent stoma. In the setting of distal rectal cancer, an intersphincteric resection is an absolute contraindication to IPAA. Pouch radiation is contraindicated because of significant functional issues with radiation enteritis. Obesity is another relative contraindication to restoration of continuity, because the small bowel mesentery often will not reach to the perineum. There is no clear-cut body mass index that precludes IPAA. Mesenteric shortening depends on the morphology of the patient. Consent should be obtained from obese patients and they should be educated about the strong possibility of a three-stage procedure or a permanent ileostomy because of their anatomy.
PREOPERATIVE PLANNING
The most important portion of preoperative planning is the consent process in patients with IBD. It is important to describe all of the risks and benefits and possible complications of the procedure. Consent requires mention of the possibility of a permanent stoma, subsequent diagnosis of Crohn’s disease, impotence, decreased fecundity, and pouchitis. It is also important to discuss the practical implications of living with a J-pouch. The average patient will have six to eight bowel movements per day, with good continence and decreased urgency. It is imperative to have trained stoma site marking and education, optimally with a stoma nurse. Nutrition is optimized as much as possible, although that can be very difficult with IBD. It is also helpful to have patients and their families speak with patients who have J-pouches.
Once the patient understands the ramifications of this procedure, the operative staging is decided and for patients with IBD the plan for the immunosuppressant medications is created. When patients are acutely ill in the hospital and the total colectomy is urgently performed, stress-dose intravenous (IV) steroids are given, which are then weaned down to the preoperative home dose at the time of discharge. When the patient presents on an elective basis, steroids can be weaned down by 5 mg/week until symptoms are intolerable. It is crucial that the patients understand that malnutrition is just as dangerous as the medications, so it is not beneficial to wean or stop immunosuppressant medications if symptoms are severe. Locally active medications are continued until the time of surgery. Biologics are stopped if symptoms are not improved with use. If symptoms are helped with biologics, it is beneficial to wait a minimum of four to five half-lives of the medication if possible to perform the operation. If patients are dependent on these medications, it is best to perform surgery at the time of the next scheduled dosing. 6-mercaptopurine, azathioprine, and methotrexate can be continued up to the time of surgery.
A complete comprehensive history and physical examination is performed with particular attention to the anal exam looking for signs of Crohn’s disease. Particular attention should be directed to the discussion of immunomodulator medications, nutritional issues, history of blood clots or anesthetic issues. Preoperative labs including complete metabolic panel (CMP), complete blood count, and type and screen should be checked. The CMP is important to evaluate liver function because UC can be linked to primary sclerosing cholangitis. If malnutrition is a concern, a prealbumin is a good measure of acute malnutrition. A chest X-ray, electrocardiogram, and/or pregnancy test should be performed in appropriate patients. For patients with cancer, appropriate preoperative staging and carcinoembryonic antigen test should be performed before any procedure. If radiation is being considered in patients with rectal cancer, it should be given before surgery.
The nontoxic patient is given an oral cathartic and oral antibiotic bowel preparation. If patients are having copious liquid bowel movements because of IBD, clear liquids the day before surgery will suffice. The patient is asked to perform a Hibiclens rinse the night before as well as the morning of the surgery. Prophylactic heparin or Lovenox is injected subcutaneously before the surgery. One dose of an antibiotic that covers gram-negative as well as gram-positive bacteria is given within 1 hour of the incision, and not continued postoperatively. If steroids were taken within 6 months of the operation, a stress dose of steroids is given before incision.
SURGERY
Positioning
The patient is positioned on the operating room table in the modified lithotomy position with both arms tucked and the patient fixed to the table at the chest and the stirrups. The anus should be positioned
off the end of the table. The hips are close to the straight position so that the knees do not interfere with the robotic arms. If the plan is for a total colectomy or double-stapled J-pouch creation, split leg extenders are a good alternative. Split leg extenders allow the surgeon access to the upper quadrants of the abdomen without interference from the stirrups and knees, although access to the perineum is difficult. A warming device is applied across the chest after fixation, and an orogastric tube and urinary catheter are placed. Sequential compression devices (SCDs) are started before induction of anesthesia.
off the end of the table. The hips are close to the straight position so that the knees do not interfere with the robotic arms. If the plan is for a total colectomy or double-stapled J-pouch creation, split leg extenders are a good alternative. Split leg extenders allow the surgeon access to the upper quadrants of the abdomen without interference from the stirrups and knees, although access to the perineum is difficult. A warming device is applied across the chest after fixation, and an orogastric tube and urinary catheter are placed. Sequential compression devices (SCDs) are started before induction of anesthesia.
The robot should be set up in a large operating theater, which should be able to accommodate the added equipment. The surgeon cart can be located in any area of the room with added space. The vision cart is usually placed to the left of the patient near the head close to the energy device console so that energy can be transferred quickly. Added laparoscopic monitors are required and should be placed opposite the vision cart. The assistant is seated to the right side of the patient, with the scrub nurse and instrument table to the right foot of the patient (Fig. 33-1). Starting a robotic program is labor intensive because the surgeon, nurses, assistants, and scrub technicians require hands-on training. It is beneficial to have a mechanical expert for the robotic system available for assistance with setup as well as equipment malfunctions.
Technique
A common misconception regarding the use of robotics in colorectal surgery is that the robot changes the procedure from the laparoscopic approach. The robot is another tool in the surgeon’s toolbox to allow the surgeon complete the surgery in a minimally invasive manner. The port placement may be different when using the robot, but the surgical approach is the same based on the surgeon. This chapter focuses on port placement and instrument choices specific to the most common robotic platforms.
Robotic Systems
The current systems available are the daVinci S, SI, and XI models (Intuitive Surgical, Sunnyvale, CA). The S and SI are older models and are very good for surgeries that focus on one or two quadrants of
the abdomen. The XI is a more recent model that is specifically designed for multiquadrant procedures with minimal redocking. Table 33-1 demonstrates the major differences between the systems. A key difference between the systems is that the XI camera can be placed through any of the 8-mm ports, and it also autofocuses. The room setup is similar to the S/SI as far as the surgeon’s console and the vision cart. The patient cart is docked 90 degrees directly to the left or right of the patient depending on the operation (Fig. 33-2). A movable operating table can be connected with the system and then the patient position can be adjusted at any point of the operation even while the robot is docked.
the abdomen. The XI is a more recent model that is specifically designed for multiquadrant procedures with minimal redocking. Table 33-1 demonstrates the major differences between the systems. A key difference between the systems is that the XI camera can be placed through any of the 8-mm ports, and it also autofocuses. The room setup is similar to the S/SI as far as the surgeon’s console and the vision cart. The patient cart is docked 90 degrees directly to the left or right of the patient depending on the operation (Fig. 33-2). A movable operating table can be connected with the system and then the patient position can be adjusted at any point of the operation even while the robot is docked.
TABLE 33-1 Differences in Robotic Systems | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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