TREATMENT

The primary goal in the treatment of renal hypoplasia is to delay the onset of ESRD. As with any form of progressive renal insufficiency, controlling hypertension is essential because it reduces intraglomerular pressure and slows the progression of glomerulosclerosis. Angiotensin-converting enzyme (ACE) inhibitors are especially useful because they exert a selective vasodilatory effect on efferent arterioles, which further reduces intraglomerular pressure and also decreases proteinuria. Once ESRD occurs, however, renal transplantation becomes the only viable longterm solution.