In adults, the prognosis is much worse, likely in large part due to the underlying comorbidities and chronic infections that predispose to PIGN. Only about half of patients will achieve complete remission of their renal disease. Poor prognostic indicators include age over 60 years, nephrotic-range proteinuria, “garland” immunofluorescence pattern, and crescentic glomerulonephritis. Especially poor outcomes occur in patients with underlying diabetic glomerulosclerosis, with one study reporting all affected patients having permanently impaired renal function and more than 80% reaching ESRD during a mean follow-up of 19 months.