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- Malignant lesions involving the head of pancreas, ampulla of Vater, distal end of the common bile duct, or duodenum.
- Absence of metastasis.
- Absence of arterial involvement.
- Refractory severe pain from chronic pancreatitis.
- Refractory to medical therapy.
- Repeat hospital admissions.
- Majority of disease limited to the head of the pancreas.
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