- Malignant lesions involving the head of pancreas, ampulla of Vater, distal end of the common bile duct, or duodenum.
- Absence of metastasis.
- Absence of arterial involvement.
- Absence of metastasis.
- Refractory severe pain from chronic pancreatitis.
- Refractory to medical therapy.
- Repeat hospital admissions.
- Majority of disease limited to the head of the pancreas.
- Refractory to medical therapy.