Open
Juan J. Nogueras
Indications/Contraindications
For the greater part of the early to mid-20th century, abdominoperineal resection with permanent colostomy was the mainstay surgical option for patients with rectal cancer. With the advent of surgical staplers and anastomotic techniques for low pelvic anastomoses, sphincter preservation surgery became the preferred option for the majority of rectal tumors. The dual objectives of modern rectal cancer surgery are to achieve excellent oncologic outcomes with adequate functional results. Low anterior resection with restorative intent is possible for tumors in the distal third of the rectum that do not invade the sphincter musculature. Anterior resection with curative intent is indicated for tumors of the mid to lower third of the rectum located below the peritoneal reflection without evidence of adjacent bony, pelvic sidewall, or sphincter musculature invasion. Palliative resection is indicated for patients without significant comorbidities and minimal metastatic disease in order to provide improved quality of life. In patients with significant comorbidities and advanced metastatic disease, nonoperative therapy is the preferred option.
The choice of operative approach today involves open, laparoscopic, and robotic techniques for anterior resection. As more surgeons become increasingly experienced with minimally invasive techniques, there is a tendency to favor these techniques over the open approach. Cheung et al. (1) published the results of a questionnaire among 386 surgeons in which they demonstrated that 77% of the study participants performed 1-20 laparoscopic resections per year (low volume), whereas a smaller percentage performed more than 20 laparoscopic resections per year (high volume). These authors demonstrated that more low volume surgeons had a preference for open anterior resection depending on specific factors, such as the age and gender of the patient, the presence of comorbidities, previous laparotomy, and locally advanced tumors.
Among experienced laparoscopic surgeons, there is a conversion rate to open surgery. In a retrospective study of 1,073 patients with carcinoma of the rectum and anus who underwent laparoscopic surgery, Yamamoto et al. (2) discovered that the conversion rate to open surgery was 7.3%. The patients who required conversion were heavier (BMI 24.6 vs. 22.7) and had a substantially higher rate of low anterior resection. Therefore, expertise in open technique for anterior resection is necessary for all surgeons who embark on minimally invasive surgery for rectal cancer.
Preoperative Planning
Adequate preoperative staging of the patient with rectal cancer involves determination of tumor level from the dentate line, depth of penetration, lymph node involvement, and distant metastases. Based on a number of criteria, selected patients will undergo neoadjuvant therapy. After completion of neoadjuvant therapy, patients are recommended to undergo resection surgery. The timing of surgery after neoadjuvant therapy has changed over recent years, and recent data by De Campos-Lobato et al. (3) suggest that a period of at least 8 weeks is associated with a higher rate of complete pathologic response and decreased local recurrence.
Patients who undergo anterior resection should be informed of specific risks involved with the surgery, especially potential injuries to the pelvic autonomic nerves resulting in sexual and bladder dysfunction (4). Moreover, patients should have some understanding of function after restorative proctectomy, with an expectation for increased frequency and urgency in the early postoperative period.
Patients are seen preoperatively by the enterostomal nurse for stoma education and optimal stoma site marking.
Surgery
Preparation and Positioning
All patients receive a preoperative full mechanical bowel preparation. Perioperative antibiotics are administered for 24 hours.
In anticipation of surgery in the deep pelvic space, the surgeon must ensure optimum visualization of tissue planes. In order to achieve this, preoperative procurement of adequate assistance, retraction, and illumination is important. Deep pelvic retractors, such as the St Mark’s retractors, are important for adequate exposure. For patients with a narrow pelvis, the illuminated, narrow blade St Mark’s retractors are especially helpful. The use of a headlight can also facilitate adequate visualization in the deep pelvis.
As was demonstrated by Pokala et al. (5), selective use of ureteral stents for adequate localization of the ureters can also be beneficial.
The patient is placed in the modified lithotomy position with careful attention to adequate padding to avoid injury to the peroneal nerve that may result in postoperative foot drop.
Technique
The surgery is approached via a midline incision. Upon entering the abdomen, a thorough exploration is performed to exclude metastatic disease. The sigmoid and descending colon are mobilized medially and the left ureter is identified. An assessment is made about the length of the descending and sigmoid colon, and the need for splenic flexure mobilization. Brennan et al. (6) reported on their experience with selective mobilization of the splenic flexure during anterior resection for rectal cancer. The ability to create a tension free and well-vascularized anastomosis determines the need for splenic flexure mobilization. The splenic flexure mobilization is facilitated with the operating surgeon standing between the legs of the patient in the modified lithotomy position. A recent study from Cleveland Clinic Florida evaluated patients referred for redo colorectal anastomosis for anastomotic stricture. In virtually every instance the splenic flexure had not been mobilized and neither the inferior mesenteric artery nor vein had been proximally divided (CCF Ref).
The peritoneum on both sides of the rectum is incised at the level of the sacral promontory, with care to avoid injury to the ureters and to the sympathetic nerves. Various means of identification of the nerves have been dissected but are rarely needed (Silva et al.). The dissection is carried underneath the superior rectal artery, and the superior rectal artery is dissected to the level of the left colic artery and inferior
mesenteric artery. The decision of the location of vessel ligation is based on the need for adequate length for a tension free and well-vascularized anastomosis (7). Division at a level just inferior to the left colic artery, with preservation of the left colic artery will result in more predictable blood supply to the anastomosis, but may not give sufficient length, especially in cases where the majority of the sigmoid is resected. Division at the level of the inferior mesenteric artery, at its takeoff from the aorta, along with proximal division of the inferior mesenteric vein, will typically ensure sufficient length for the anastomosis. The anastomosis will then rely on blood supply from the marginal artery of Drummond, based on the middle colic artery. The level of vessel division has not been demonstrated to have an effect on the oncological outcome of the operation (8).
mesenteric artery. The decision of the location of vessel ligation is based on the need for adequate length for a tension free and well-vascularized anastomosis (7). Division at a level just inferior to the left colic artery, with preservation of the left colic artery will result in more predictable blood supply to the anastomosis, but may not give sufficient length, especially in cases where the majority of the sigmoid is resected. Division at the level of the inferior mesenteric artery, at its takeoff from the aorta, along with proximal division of the inferior mesenteric vein, will typically ensure sufficient length for the anastomosis. The anastomosis will then rely on blood supply from the marginal artery of Drummond, based on the middle colic artery. The level of vessel division has not been demonstrated to have an effect on the oncological outcome of the operation (8).
Total Mesorectal Excision