Potentially long-term life-threatening complications, including second malignant neoplasms, cardiovascular disease, neurotoxicity and ototoxicity, pulmonary complications, hypogonadism, and nephrotoxicity have accompanied the remarkable successes of testicular cancer treatment.

Testicular cancer survivors should follow applicable national guidelines for cancer screening and management of cardiovascular risk factors.

Health care providers should capitalize on the time of testicular cancer diagnosis as a teachable moment to introduce and promote lifestyle changes in testicular cancer survivors, including smoking cessation, better nutrition, and participation in a regular exercise regimen.

Testicular cancer is positioned to become a paradigm in survivorship research for adult-onset cancer and the most comprehensive multi-institutional study to date is currently underway to examine genetic variants associated with long-term toxicities of platinum-based chemotherapy in testicular cancer survivors.