The stress response and the resulting activation of a cascade of hormonal and neurochemical reactions are essential to enhance the survival of organisms in the short term. However, when stress is extreme or becomes chronic, it can lead to compromised functioning. In the face of a lifelong biological stressor like IBD, chronic stress exposure is associated with worse disease course, more chronic pain, and reduced quality of life [3]. Both experienced and perceived stress has been shown across multiple studies to contribute to the risk of relapse in IBD. Psychological stress responses can occur across a spectrum of severity from situational symptoms of emotional distress to functionally impairing psychiatric syndromes. Patients with IBD may have other factors predisposing to an exaggerated stress response unrelated to their disease such as other comorbid medical diagnoses, history of trauma, social conflict, and those with genetic vulnerability to psychiatric disorders (e.g., positive family history) [2]. Collectively, the presence and severity of these factors determine what type of stress management may help patients the most.