Some patients will require prophylactic treatment to prevent recurrent infection. Some young women, for example, experience frequent UTIs associated with sexual intercourse. These patients should be advised to void after sexual activity and can be prescribed antibiotics for single-dose postcoital chemoprophylaxis. Trimethoprim-sulfamethoxazole, nitrofurantoin, or ciprofoxacin can be used in this setting. In postmenopausal women, use of intravaginal estriol cream has been shown to decrease the recurrence of UTIs. Other nonspecific therapies, such as hydration and maintenance of an acidic urine pH, are also reasonable options.