Anal Fistula



Anal Fistula


Alex Jenny Ky

Emily Steinhagen



Bertram: What is it, my good lord, the King languishes of? Lafew: A fistula, my lord.

—WILLIAM SHAKESPEARE: All’s Well That Ends Well, 1.1.37

A fascinating narrative of Shakespeare and the literary history of anal fistula has been written by Cosman.44


▶ HISTORY

Anal fistula is a condition that has been described virtually from the beginning of medical history. Hippocrates, in about 430 BCE, suggested that the disease was caused by “contusions and tubercles occasioned by rowing or riding on horseback.”4 He was the first person to advocate the use of a seton in treatment (from the Latin seta, a bristle) “taking a very slender thread of raw lint, uniting it into five folds of the length of a span, and wrapping them round with a horse hair.”4 Numerous commentaries have been written on the historical implications associated with anal fistula (see Abu Marwan bio). For example, it has been known that the Sun King, Louis XIV, developed an abscess on February 18, 1685, and by May 2 a fistula had appeared. His doctors tried to treat him, unsuccessfully, with enemas and poultices. Eventually, Charles-François Felix was sent for. Felix recommended an operation, and Louis agreed to it. Felix, however, requested 6 months to prepare himself. He had never done such an operation before, and he needed to practice. He performed the procedure on 75 peasants, men who didn’t actually need the operation. Not all of them lived. On November 18, 1686, at 7 o’clock in the morning, Felix operated on the king. The king was calm, but the surgeon was terrified. The operation was performed without anesthetic. Felix had devised a special curved scalpel and unique retractor. The operation was a success. King Louis was able to sit up in bed within a month, and in another 3 months he was able to ride again. Word of his great courage during the operation spread throughout the court, and some of the nobles took to wearing bandages on their buttocks in the king’s honor. The procedure became known as “the Royal,” and at least 30 nobles asked Felix to perform the same operation on them. They were greatly disappointed when he told them that they didn’t need it. In gratitude for his services, Felix was given a large sum of money, a title, and an estate. The status of surgeons was greatly improved by the event, and in 1731 Louis XV, Louis XIV’s grandson, would establish the Royal Academy of Surgeons. As for Charles-François Felix, he was apparently greatly shaken by his experience. He never touched a scalpel again.

The fascination with anal fistula for more than 2,000 years is manifested by the numerous papers and books on the subject. In fact, Salmon established a hospital in London devoted to the treatment of anal fistula and other rectal conditions— St. Mark’s. Allingham also established his reputation through operations for anal fistula. His book on rectal surgery was published through numerous editions.

It has been said that more surgeons’ reputations have been impugned because of the consequences of fistula operations than from any other operative procedure. Complications of fistula surgery are myriad and include fecal soilage, mucous discharge, varying degrees of incontinence (gas and/or stool), recurrent abscess, and recurrent fistula. In the United States, impairment for bowel control from even a properly performed operation for anal fistula is one of the most frequent reasons in the field of colon and rectal surgery for a patient to pay a visit to an attorney. It is for this reason that the prescient surgeon will make a special effort to explain in detail the attendant risks of the procedure. Moreover, it is critically important to
document the state of that individual’s continence prior to embarking on any procedure. The fact is that no one goes whole to the grave with perfect anal control following surgery if an anal fistula traverses a significant portion of the external sphincter. Clearly, the surgeon who is fortunate enough to have the opportunity to treat the patient initially is the one most likely to effect a cure, to limit morbidity, and to minimize disability.




▶ CLASSIFICATION

The most commonly referred classification was suggested by Parks and colleagues.137





























Intersphincteric



Simple low tract


High blind tract


High tract with opening into rectum


High fistula without a perineal opening


High fistula with extrarectal or pelvic extension


Fistula from pelvic disease


Transsphincteric



Uncomplicated


High blind tract


Suprasphincteric



Uncomplicated


High blind tract


Extrasphincteric



Secondary to transsphincteric fistula


Secondary to trauma


Secondary to anorectal disease (e.g., Crohn’s)


Secondary to pelvic inflammation


Combined


Horseshoe



Intersphincteric


Transsphincteric



Although not included in this classic schema, “complex fistula” is defined as other than an intersphincteric or low extrasphincteric fistula. The implication is that they are more difficult to treat than conventional fistulas and, in addition, are associated with increased risk of recurrence as well as a greater likelihood for impairment of control. These fistulas have also been labeled “problematic” by some.1,167 Frenkel proposed a classification based on the level of the fistula: low, mid, and high/complex.57 However, five types of fistulas are generally described by most authors. They are as follows:


The submucous fistula is a misnomer. See the discussion in Chapter 13.

As its name suggests, an intersphincteric fistula passes through the internal sphincter to the skin. Occasionally, an extension may be observed to proceed cephalad in the intersphincteric plain (i.e., high blind tract), but this has no consequence in one’s therapeutic decision making. It has also been
reported to extend cephalad and present with another opening in the rectum.137 Only the most superficial or subcutaneous portions of the external sphincter may be divided when a fistulotomy is undertaken. Intersphincteric fistulas are the most common type of fistula, with an incidence of 55% to 70%.






FIGURE 14-1. Intersphincteric fistula. The tract passes through the internal sphincter and in the intersphincteric plane.






FIGURE 14-2. Transsphincteric fistula. The tract passes through both the internal and external sphincters, into the ischiorectal fossa, and to the skin.

A transsphincteric fistula passes through both the internal and external sphincters before exiting to the skin. It usually results from an ischiorectal abscess. The level of the tract determines how much sphincter will need to be divided and the risk of impairment for bowel control if a fistulotomy is performed. This type of fistula is observed in 20% to 25% of most series. Occasionally, a supralevator extension of a transsphincteric fistula is identified (Figure 14-5). Treatment requires recognition of this condition, curettage, irrigation, and packing of the supralevator extension. Under no circumstances should the extension be drained into the rectum.






FIGURE 14-3. Suprasphincteric fistula. The tract courses above the puborectalis muscle after initially passing cephalad as an intersphincteric fistula. It then traverses downward through the ischiorectal fossa to the skin.






FIGURE 14-4. Extrasphincteric fistula. The internal opening is above the level of the levator ani muscle, and the tract passes to the skin deep to the external sphincter in the ischiorectal space.

A suprasphincteric fistula was noted by Parks and colleagues to comprise 20% of their series.137 Other series have reported
that this type of fistula is extremely rare and only constitutes approximately 1% to 3% of fistulas.4 The fistula is described as starting in the intersphincteric plane, passing to a supralevator location, and ultimately tracking between the puborectalis and the levator ani muscles to end in the ischiorectal fossa.






FIGURE 14-5. Transsphincteric fistula with supralevator extension. Drainage of the extension into the rectum is contraindicated.

The extrasphincteric fistula involves a supralevator internal opening with a tract that passes through the entire sphincter mechanism torward its exit at the skin. It is usually a consequence of trauma (e.g., foreign body, surgical manipulation, impalement), Crohn’s disease, or pelvic inflammatory disease. It can also develop when a supralevator abscess or transsphincteric fistula with supralevator extension ruptures spontaneously into the rectum. This type of fistula represents approximately 2% to 3% of fistulas, but if the physician’s practice encompasses many individuals with inflammatory bowel disease, the incidence could be higher.


▶ PRACTICE PARAMETERS FOR TREATMENT

As has been mentioned in prior chapters, practice parameters for the treatment of a number of colorectal conditions have been established by the Standards Practice Task Force of the American Society of Colon and Rectal Surgeons. These recommendations have also been established for the evaluation and treatment of fistula-in-ano.178 The reader is advised to review the society’s guidelines with respect to the latest revisions concerning evaluation and treatment of this condition.


▶ IDENTIFICATION OF THE FISTULA TRACT

How does the physician identify the type of fistula, the course of the tract, and the location of the internal opening? Numerous methods can be employed, the basic principles and procedures of which include the application of Goodsall’s rule,67 careful physical examination, probing of the tract, and a variety of injection and radiologic techniques.


Goodsall’s Rule

When the external opening lies anterior to the transverse plane, the internal opening tends to be located radially. Conversely, when the external opening lies posterior to the plane, the internal opening is usually (but not always) located in the posterior midline (Figure 14-6). One must remember that this is a “rule,” not a “law.” There are exceptions to “rules.”






FIGURE 14-6. Typical courses of fistula tracts according to Goodsall’s rule.

There is some controversy over the reasons for the disparate manifestations. However, the reason for this eventuality probably lies with the fact that the posterior course is the result of a defect in fusion of the longitudinal muscle and the external sphincter in the posterior midline. A transsphincteric fistula is, therefore, more likely to occur in this position; the tract can then dissect into one or both ischiorectal fossae.

Cirocco and Reilly analyzed the predictive accuracy of this rule by reviewing 216 patients who underwent fistula surgery.41 Only 49% of those who harbored an external opening anterior to the transverse plane had radially directed fistulas, but the accuracy rate of Goodsall’s rule regarding posterior secondary openings was much greater.

Essentially, the rule should merely be used as a guide to help the surgeon find the tract when it may not be apparent. It is not a substitute for meticulous technique, clear identification of the direction of the tract, and location of the internal opening.

Usually, there is only one external or secondary opening. Most commonly, fistulas pass in the intersphincteric plane, but with transsphincteric fistulas, multiple openings can develop from communication with the deep postanal space and from the ischiorectal fossae; this is the origin of the so-called transsphincteric horseshoe fistula (see later).




Physical Examination and Endoscopy

Careful palpation may reveal the thickened tract proceeding into the anal canal if the fistula assumes a relatively superficial position. This finding is most characteristic of an intersphincteric fistula. Bidigital examination, placing the thumb on the outside and the index finger within the anal canal, may also help to reveal the course of the tract. Failure to identify the tract by palpation implies that it is deep and, therefore, more likely to be a transsphincteric fistula. Anoscopic examination may demonstrate an internal opening or purulent material exuding from the base of the crypt. By gentle probing with a crypt hook or malleable probe (Figure 14-7), the presence of the tract may be confirmed. This maneuver is easier to accomplish for a radially located fistula than for one that opens in the posterior midline. Occasionally, the tract will pass subcutaneously for a considerable distance and end in the perineum, scrotum, labia, or thigh (Figure 14-8). Failure to identify the internal opening does not mean that it has closed, however. Angulation or narrowing of the tract may preclude the possibility of adequate evaluation by probing, and excessive manipulation will certainly lead to considerable discomfort for the patient. Under these circumstances, examination under an anesthetic may be required to adequately delineate the course of the tract unless one wishes to perform special studies.






FIGURE 14-7. Anorectal probes. A: Larry. B: Barr. C: Buie. D: Pratt. E: Barr double-ended. F: Pratt crypt hook. G: Stewart crypt hook. H: Rosser crypt hook. I: Blanchard cryptotome. J: Barr crypt hook.






FIGURE 14-8. Scrotal fistula. The multiple openings are due to extensive subcutaneous tracking. Although on cursory examination the fistula may appear to be difficult to treat, the tract is usually quite superficial.

At the time of bidigital examination, baseline sphincter tone, bulk, and squeeze should be assessed because this may affect the risk of incontinence with a surgical procedure.


Passing a Probe

As implied, passage of a probe can be attempted from both the external and the internal openings. Sometimes it is easier to identify the tract from the internal opening, but probing through the external one will usually reveal the course more readily. Simultaneous passage of two probes, from the internal and the external openings, may confirm the tract’s location if the tips of the probes touch. A stenotic or sharply angulated area within the tract may preclude complete passage from either end. The probe should never be forced, merely gently maneuvered in order to avoid creating another tract or sinus (Figure 14-9).


Traction on the Tract

Theoretically, if the physician mobilizes a small portion of the tract from the secondary (i.e., external) opening and
applies traction, an indentation or dimpling will be evident at the level of the crypt—the site of the internal opening (Figure 14-10). With the exception of the most simple, radially directed tracts, we have not found this particular maneuver to be helpful especially when the tract is friable and with little substance to pull on. The variable and often curvilinear course of more complex fistulas lessens the potential benefit of this method for tract identification.






FIGURE 14-9. A malleable probe is passed from the external to the internal openings to confirm the course of the tract.


Injection Techniques


Dye

A DeBakey olive-end needle may be used to inject material through the opening and into the tract while an anoscope is in position in the rectum (Figure 14-11). We like to cut a 20-gauge angiocatheter at an angle to facilitate cannulation of the fistula tract. If a substance such as methylene blue or indigo carmine is injected through the tract, the dye may appear in the rectum, confirming the patency of the tract and its communication with an internal opening. The problem with such agents is that the surgeon may have only one opportunity to visualize the internal opening before the material stains the mucosa and the whole anal canal. It has been said that it would be as sensible to pour ink on a newspaper in order to facilitate reading.51 If the surgeon has no other available agent except dye, I suggest diluting it down to one part per 20.






FIGURE 14-10. Attempt at identification of the primary (i.e., internal) opening by pulling on the epithelialized tract with a clamp. This may create a “dimpling” at the internal opening because of tethering, indicating where the opening should be. This approach is unlikely to be successful unless the tract is radially located.






FIGURE 14-11. A DeBakey olive-end needle has a bulbous tip that permits insertion into the external opening without penetrating the wall of the tract (A). Alternatively, an Angiocath may be used (B).



Milk

Milk can also be used to identify the tract and the internal opening; sterility is not required. The milk can be wiped away without staining the tissue, permitting repeated attempts to inspect the internal opening. Failure to demonstrate communication with the internal opening implies stenosis of the tract, but if the milk is seen in the submucosa of the anal canal, even without escaping into the lumen, the associated crypt-bearing area should be excised with the presumption that the internal opening has closed.


Hydrogen Peroxide

Hydrogen peroxide injection is an ideal means for identifying the internal opening. The liberated oxygen may be seen to bubble through the internal opening. The pressure created by the gas may be sufficient to penetrate even a stenotic tract and pass into the anal canal. Additionally, staining of the tissue does not occur.


Imaging


Fistulography

Fistulography, the radiologic delineation of a fistula tract with a water-soluble contrast agent, is thought generally to be of limited value, having essentially been completely replaced by endoluminal sonography and magnetic resonance imaging (MRI).181 However, the technique is quite simple to perform. The patient is placed on the x-ray table, usually in the left lateral position, and a small-bore catheter is inserted into the external opening. A few milliliters of water-soluble contrast material are injected, and films are taken in several projections (Figures 14-12 and 14-13).

This technique does not directly image the sphincters. Thus, the relationship between the fistula and sphincter muscle cannot be determined with certainty. Additionally, the specific location of the internal opening within the anal canal is often impossible to determine. Furthermore, extensions from the primary tract may not fill, and, therefore, will not be visualized.72






FIGURE 14-12. Fistulogram with water-soluble contrast material demonstrates the course of a transsphincteric fistula with an internal opening at the level of the anorectal ring.






FIGURE 14-13. Fistulogram of an extrasphincteric fistula. The tract enters the rectum at the level of the arrow.

Several small studies have come to conflicting results about the usefulness of this technique. In one retrospective review of fistulography compared with subsequent surgical findings in 25 cases, fistulograms were accurate in only 16%, and false-positive results were identified in 10%.100 However, another retrospective review of 27 patients who underwent anal fistulography noted that 48% harbored unexpected pathologic features that led to an alternative surgical treatment.9 One prospective study involving 50 patients came to the conclusion that fistulography provided “helpful information.”197

The limitations of fistulography have led most specialists in colon and rectal surgery to abandon it because more precise imaging modalities are now available.


Endoanal Ultrasound

Endoanal ultrasound (EUS) may be used to image the anal canal and surrounding pelvic structures. The technique is simple to perform, although it is operator-dependant. It is noninvasive, inexpensive, and generally well tolerated. Most studies examining the accuracy of endoanal ultrasound report excellent correlation with surgical findings, particularly in visualizing the primary tract.36,46,105,187 One report noted that the surgical procedure was influenced by ultrasonographic findings in up to 38% of cases.110 In one study that compared digital examination with ultrasound, the two were equally able to identify intersphincteric and transsphincteric tracts, but ultrasound was unable to assess superficial, suprasphincteric, extrasphincteric, and supralevator or infralevator tracts. Digital examination was, therefore, considered more reliable.36

The inability to identify all extensions of complex fistulas or even primary tracts when they are beyond the reach of the instrument is a limitation of this technique. Furthermore,
scar or inflammatory tissue and the presence of abscess may limit the ability to distinguish the anatomic structures that otherwise are usually seen on endoanal ultrasound. Abscess, in particular, can appear similar to adipose tissue seen in the ischiorectal fossa. It has also typically been difficult to identify the internal opening of a fistula in the mucosa. To aid in the identification of the internal opening, the following criteria have been suggested by Cho35:



  • Criterion I. Rootlike budding formed by the intersphincteric tract, which contacts the internal sphincter.


  • Criterion II. Rootlike budding within the internal sphincter defect.


  • Criterion III. Subepithelial breach connecting to the intersphincteric tract through an internal sphincter defect. Using these criteria, the internal opening may be identified in approximately 76% of cases.

However, it is unclear how many were able to be identified based on physical examination alone.

The addition of hydrogen peroxide appears to improve the accuracy of endoanal ultrasound, particularly for identifying the internal opening and secondary extensions of the fistula tract (Figure 14-14).106,144,148 The hydrogen peroxide forms hyperechoic gas bubbles that can enhance visualization of the tract (Figure 14-15). This has been particularly helpful for recurrent or complex disease in some studies, but other authors note that the improved imaging does not necessarily translate to changes in management.27 Threedimensional ultrasound has also been suggested to improve the accuracy of endoanal ultrasound. It can be used to create reconstructed images of the coronal and sagittal planes; this can be helpful in clarifying the relationship of the fistula to surrounding structures. The two techniques have been combined, but some have reported no additional benefit over three-dimensional imaging alone.95,99 Postprocessing, volume-rendered imaging has also been suggested for the enhancement of the image created by traditional ultrasound. This approach may improve contrast between structures so that primary tracts can be classified more accurately and potentially detect an abscess. However, it has not been found to affect treatment planning.20






FIGURE 14-14. Transsphincteric fistula and the internal opening. Axial hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography image (A) and axial endoanal magnetic resonance imaging (T2-weighted, gradient echo) image (B) showing the endoprobe (1) and anal coil (1), submucosa (2), the internal anal sphincter (3), the external anal sphincter (4), the fistula and the internal opening (5; black arrow), fibrosis (6), and the bulbocavernous muscle (b). A, anterior; R, right; F, feet; L, left; and P, posterior. (From West RL, et al. Prospective comparison of hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography and endoanal magnetic resonance imaging of perianal fistulas. Dis Colon Rectum. 2003;46(10):1407-1415, with permission.)






FIGURE 14-15. Coronal image of a transsphincteric fistula. Hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography image (A) and endoanal magnetic resonance (T2-weighted, fast spin echo) image (B) showing the endoprobe (1) and anal coil (1), the internal anal sphincter (3), the external anal sphincter (4), the fistula and the internal opening (5; arrow), fibrosis (6), puborectal muscle (7), and levator ani muscle (8). H, head; A, anterior; L, left; R, right; and F, feet. (From West RL, et al. Prospective comparison of hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography and endoanal magnetic resonance imaging of perianal fistulas. Dis Colon Rectum. 2003;46(10):1407-1415, with permission.)

Endoanal ultrasound may be particularly helpful in the evaluation of Crohn’s fistulas. Accuracy has been reported to be up to 91%.134,162 When a patient is treated with infliximab,
the superficial opening of the fistula may appear to have healed. However, a persistent fistula may be demonstrated on ultrasound.11 Anal ultrasound is typically not used for the characterization of straightforward fistulas. It may, however, be helpful in specific situations, such as the inability to demonstrate an internal opening, recurrent or persistent fistula following surgery, Crohn’s disease, or complicated cases.


Magnetic Resonance Imaging

MRI produces detailed images of the perianal region and of fistula tracts via magnetic fields and radiofrequency energy. A variety of sequences and techniques, some using endoluminal anal coils, have been used. It is useful for demonstrating the relationship between the sphincters, soft tissues, and fistulas in all planes. An advantage over that of EUS is the ability to image the entire pelvic region and to, at least theoretically, see all extensions of a fistula. MRI appears to have the greatest concordance with clinical and surgical findings when compared with EUS or CT, with reported accuracy rates of 85% or greater.28,84,113 In one study, when discordance was noted between tracts on MRI not identified during surgery, there was a 52% recurrence rate following surgery.127 Subsequent findings confirmed the MRI in all cases. In contrast, the failure rate was 13% when there was concordance between surgical and MRI findings. However, in this study, surgeons acted on the MRI in 21% of cases, which biased the results. The same authors note in another small series that even though MRI can alter plan of surgery, in many instances the disagreement between imaging and examination findings did not affect the treatment plan because the classification differences were not clinically significant.30

Dynamic contrast-enhanced MRI has been compared with physical examination and surgical exploration.16 It appears to have a high sensitivity and specificity and is able to identify more secondary tracts. Moreover, it is felt to be more accurate in identifying complex fistulas than either digital rectal examination alone or surgical exploration.

Because of the ability to visualize extensions or areas of abscess in the pelvis not accessible by physical examination, one small study suggested that MRI may be superior to EUS at predicting outcomes of surgery.177 Spencer and colleagues reported positive and negative predictive values of 73% and 87%, respectively, for MRI and 57% and 56% for EUS.177 Others have noted that MRI may provide helpful additional information beyond what is found at EUS. In one study, MRI was particularly useful in Crohn’s disease and in classifying recurrent fistulas, thus providing helpful additional information in 40% and 24% of these situations, respectively.17 However, in two studies evaluating the use of EUS and MRI for Crohn’s fistulas, EUS was superior.162 Importantly, when any two methods were combined in one of the studies, the accuracy was reportedly to be 100%.134 This suggests that a multimodality approach may be beneficial. As with EUS, MRI can be used to evaluate the response of Crohn’s fistulas to infliximab, often showing the persistence of a fistula in the presence of superficial healing.

It is important that an MRI used to delineate fistula anatomy be read by a radiologist with experience in pelvic anatomy because there is a learning curve associated with its interpretation.161 The cost and accessibility of the machine must also be taken into account, as should medical contraindications, such as pacemakers or the inability of the patient to tolerate the contrast material. In all studies comparing imaging to either physical examination or surgical findings, the “true” or correct classification of the fistula is not known with certainty. In difficult cases, it may be impossible to truly delineate the course of the fistula. Therefore, critical review of such reports is required.


Additional Gastrointestinal Studies

Gastrointestinal evaluation, in addition to rigid or flexible sigmoidoscopy, is generally unnecessary for patients with conventional anal fistula. However, in the presence of known or suspected inflammatory bowel disease, colonoscopic examination and a small bowel series are strongly encouraged.


▶ PRINCIPLES OF SURGICAL TREATMENT

Although the history of the treatment of anal fistula by means of a seton can be traced to ancient Greece (see earlier discussion), al-Zahrawi (Albucasis) is recognized as the first to use cauterization for this condition (10th century). The
management of anal fistula by division or “laying open” the tract was initially described by John of Arderne in the 14th century.10 With minor variations, this is the same method that is most commonly employed today. Percivall Pott suggested that there are essentially three means for cure: caustic, ligature, and incision.


The surgeon who initially treats the patient has the best opportunity to identify the tract, find the internal opening, and effect a cure. When this is not accomplished in the first instance, further surgery may be more complex, and the patient will be subjected to an increased risk of complications.

Failure to cure the patient is usually the result of either timorousness or temerity. If the surgeon traces the tract from the external opening to the level of the crypt but cannot pass the probe into the anal canal and subsequently desists from excising the crypt-bearing area, one is being too timid. In this situation, it is reasonable to assume that the crypt opening has sealed and that it is, indeed, the source of the fistula (Figure 14-16A). Likewise, if the surgeon identifies the internal opening of a “virgin fistula” but is reluctant to lay it open because of fear that the opening is too high, that decision may jeopardize the opportunity of curing the patient. The fistula will inevitably persist, and the subsequent procedure will be performed without the security of knowing that the observed internal opening occurred as a natural consequence. With few exceptions (e.g., Crohn’s disease, a history of trauma), the surgeon should be able to open the tract at the time of the initial operation without fear of causing significant impairment for bowel control. If there is concern about the safety of dividing at the level of the internal opening, a seton can be temporarily employed (see later).

Conversely, if the tract is identified only partially (i.e., not to the level of the crypt), and the surgeon elects to guess or to assume where the opening should be, thereby creating an “artificial” internal opening, one is being too aggressive (Figure 14-16B). The actual opening and the tract have not been appreciated. When the surgeon is subsequently confronted with a persistent fistula after such an ill-conceived maneuver, both the natural and the artificial internal openings must be considered.

The previously mentioned injection techniques may confirm the presence of the fistula and the internal opening. They do not, however, identify the course of the tract. If a probe can be passed, it is only necessary to incise down onto it.
However, if this cannot be accomplished and should a fistulotomy be elected, the dissection must be carried out slowly and meticulously, following the epithelialized tract until it communicates with the anal canal (Figure 14-17).








FIGURE 14-16. Probing the tract may reveal that the internal opening has sealed. A: If the tip of the probe can be appreciated at the level of the crypt, a fistulotomy may be undertaken with safety. B: However, creating an “artificial” internal opening is contraindicated at a higher level.

A fistula operation should always be performed with electrocautery. Identification of the tract requires a dry operative field. In such a vascular area, this is the best means for maintaining hemostasis.


Fistulotomy versus Fistulectomy

Whether to perform fistulectomy or fistulotomy has been a source of controversy. Kronborg randomly allocated patients with anal fistula to either an incisional or an excisional approach.98 Times to healing were significantly shorter when the fistula was laid open in comparison with excision, but recurrence rates were comparable. Fistulotomy is preferable because of the prolonged healing time associated with excisional techniques (Figures 14-18 and 14-19). However, a small portion of the tract may be removed for pathologic examination, especially if there is a concern about the possibility of Crohn’s disease or malignancy (see later).


Office Fistulotomy

Office fistulotomy may be undertaken synchronously with drainage of an abscess if the internal opening is low or if it is an intersphincteric fistula. It may also be performed in the office as an interval procedure following abscess drainage. Local anesthesia or a field block is usually adequate for analgesia (see Chapters 8 and 11). For the majority of patients, however, definitive fistula surgery should be performed in the operating room with a general, spinal, or caudal anesthetic under optimal conditions. A local anesthetic with conscious sedation may also be used in selected individuals. With the exception of certain complex fistulas or those in whom concomitant sphincter repair is undertaken,
the operation can usually be performed on an ambulatory basis. This is also in accordance with the recommendations of the Standards Task Force of the American Society of Colon and Rectal Surgeons.179 However, the most current set of recommendations does not specifically address the issue of inpatient or outpatient management.180 Their conclusions were as follows:






FIGURE 14-17. Progressive unroofing of a fistula with electrocautery, following the tract with the aid of a probe.






FIGURE 14-18. Fistulectomy versus fistulotomy, matters of prolonged wound healing, scarring, and deformity.






FIGURE 14-19. Anal fistulectomy may require prolonged healing time. This wound is still open 6 weeks after the operation.



  • A fistula, fistula with abscess, or a fistula associated with limited anorectal pathology may be treated on an outpatient basis if, in the judgment of the operating surgeon, it is safe to do so.


  • Fistulas involving adjacent organs or structures (i.e., rectovaginal, rectourethral, or horseshoe) often require more extensive surgery, and inpatient postoperative care is usually needed.


  • Fistulas associated with extensive cellulitis or abscess or additional anorectal disease may require inpatient care, especially if intravenous antibiotics are necessary.179


▶ SURGICAL APPROACHES AND RESULTS


Treatment of Conventional Fistula

After the external and internal openings have been identified by one of the means mentioned previously, the tract is incised (Figure 14-20). Continuity of the epithelial lining confirms the completeness of the operation, and granulation tissue is removed by curettage. A portion of the tract may be excised and sent for pathologic examination. The external portion of the incision may be widened relative to the size of the opening in the anal canal because skin tends to heal more rapidly than anal mucosa. If this is not done, delayed healing within the anal canal may result. The cut edges of the anal mucosa and the underlying internal anal sphincter can be oversewn with absorbable suture for hemostasis (Figure 14-21). The wound is otherwise left open and gently packed. Petroleum jelly gauze is preferred by some surgeons because subsequent removal is less likely to induce bleeding. Others endorse the use of iodoform
gauze, Surgicel, Telfa, or simply a gauze sponge. Tight packing should be avoided because it can lead to cellulitis and abscess.






FIGURE 14-20. Conventional fistulotomy. With the use of electrocautery, the tract is laid open between the internal and external openings.






FIGURE 14-21. Conventional fistulotomy. The anal opening with the underlying internal sphincter is sutured for hemostasis.






FIGURE 14-22. Anterior fistula in a female patient may be treated by repair of the external sphincter. A: Fistulotomy dividing a portion of the external sphincter. B: Repair of the sphincter is effected, and the wound is left open.

To reiterate, the principles of operative treatment are as follows:



  • Identify the tract.


  • Incise the tract.


  • Excise a portion for biopsy material (if considered potentially useful).


  • Widen the external wound.


  • Suture the cut edge of the anal canal.


  • Gently pack the wound.

The dressing is removed the evening of surgery or the next day, and sitz baths should be performed. Vigorous mechanical cleansing of the wound is encouraged with either a washcloth or a gauze pad. The use of a Water-Pic device or comparable irrigating equipment has merit in postoperative wound management. One should be as vigorous as possible, maintaining the wound in a well-debrided and clean state. An office visit is recommended 10 days later to assess healing, and usually every 1 to 2 weeks thereafter until healing is complete. Less frequent appointments may be appropriate for individuals with straightforward fistulas if the patient understands the need for and is committed to vigorous cleansing.

If a large portion of the external sphincter must be divided, consideration should be given to primary sphincter repair or possibly to seton division (see later discussion). An anterior fistula in a woman should always be considered for either reconstruction or another alternative to limit sphincter damage (Figure 14-22). When a fistula occurs anteriorly in a
woman, surgical treatment inevitably will create some degree of impaired control. To minimize the disability, sphincter reconstruction should be attempted at the time of fistulotomy. Another alternative for managing such a problem is to use a seton or to perform a closure of the internal opening with a sliding endorectal flap, such as that which may be recommended for rectovaginal fistula repair and high transsphincteric anal fistulas.




Horseshoe Fistula

Horseshoe fistula may be intersphincteric but is much more frequently transsphincteric. It is so called because it is composed of multiple external openings joined by a subcutaneous communication in a U or horseshoe shape (Figure 14-23). The arms of the U are almost always directed anteriorly, and the internal opening is in the posterior midline. Rarely, a horseshoe fistula may present with the opposite configuration; that is, the internal opening is in the anterior midline, and the arms of the U are directed posteriorly.

Treatment of this condition has evolved to be much less radical than originally described. The classic procedure required identification of the tracts and internal opening and unroofing or excision of each of them (Figure 14-24). This inevitably resulted in a huge, gaping wound, which required a prolonged healing time (Figure 14-25). Disability after this operation can last for many months.

In 1965, Hanley described a rather conservative approach to the management of horseshoe fistula that limits the number and extent of the incisions.75 The most important aspects of the operation are to eliminate the internal opening and to establish adequate external drainage.58,75 Because all of the tracts and external openings communicate, if the internal opening has been removed, the external openings will close. Most surgeons have successfully adopted this approach to the treatment of horseshoe anal fistula.

If the fistula is transsphincteric, the deep postanal space must be entered, curetted, and irrigated (Figure 14-26). This involves incision of both the internal sphincter and a portion of the external sphincter. It is then necessary only to unroof the external openings, curette the tracts, and drain the wounds (Figure 14-27). The cut edges of the anal canal and underlying internal sphincter are sutured for hemostasis. The deep postanal space is packed loosely, usually with iodoform gauze, and a dressing is applied.






FIGURE 14-23. Representation of a horseshoe anal fistula. The internal opening is in the posterior midline.






FIGURE 14-24. Classic treatment of horseshoe fistula with excision of all openings.

When the fistula is approached in this way, healing is generally rapid, and the risk of functional impairment to the anus from scarring and deformity is decreased. Duration of disability is also markedly reduced.

Postoperatively, the packing is removed in 24 to 48 hours, and the patient may begin sitz baths. Weekly office visits are recommended until the wounds have healed.



Treatment of Suprasphincteric Fistula

The management of suprasphincteric fistula is comparable to that of other complex fistulas. Options include endorectal advancement flap, primary closure and drainage, and seton division. In general, once the fistula has been recognized as such, fistulotomy can be accomplished distal to the internal opening by dividing the lower portion of the internal and external sphincters (Figure 14-28). The cephalad component, including the internal opening, is treated by means of seton division (see later). It is important to assess the length of the canal because men tend to have longer anal canals, whereas women tend to have shorter. Sufficient muscle must remain to preserve continence.








FIGURE 14-28. Suprasphincteric fistula. A: The tract courses above the levators, passing through to the skin in the ischiorectal fossa. B: The internal and external sphincters have been incised, but the high opening is treated by seton division to minimize the risk of fecal incontinence.

Jul 17, 2016 | Posted by in GASTROENTEROLOGY | Comments Off on Anal Fistula

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