PROGNOSIS

In AL amyloidosis, the prognosis depends on the degree of systemic involvement (especially cardiac involvement) and the degree to which therapy reduces free light chain production. Although AL amyloidosis was previously considered a rapidly fatal disease, patient survival appears to be increasing with current treatment regimens.

In AA amyloidosis, the prognosis depends on the activity of the underlying disease, and infections are the major cause of death. There have been well-documented cases of remission of AA amyloidosis with control of the infectious source.