Endoscopic resection techniques have transformed the management of colorectal lesions, including diminutive (≤5 mm), small (6–9 mm), medium (10–19 mm), and large (≥20 mm) colorectal lesions. Herein, we demonstrate the application of various resection techniques including cold‐snare polypectomy (Figures 83.1 and 83.2), conventional polypectomy (Figure 83.3), endoscopic mucosal resection (EMR) (Figure 83.4), and endoscopic submucosal dissection (Figure 83.5). This includes the management of complex lesions, including those involving the ileocecal valve, appendiceal orifice, and anorectal junction (Figure 83.6), as well as lesions with nonlifting polypoid tissue (Figure 83.7). Moreover, we demonstrate the management of periprocedural adverse events, including clinically significant intraprocedural bleeding and deep mural injury (Figure 83.8), and delayed bleeding (Figure 83.9).