Adolescent varicocele have been associated with testicular volume loss, endocrine abnormalities, and abnormal semen parameters [251]. Severe testicular damage is found in 20 % of adolescents affected, with abnormal findings in 46 % of affected adolescents. Histological findings are similar in children or adolescents and in infertile men. In 70 % of patients with grade 2 and 3 varicocele, left testicular volume loss was found.