Validity of the Japanese Clinical Grade Criteria: Results from the Nationwide Retrospective Cohort Study in IgA Nephropathy

C-Grade I

C-Grade II

C-Grade III

Number of patients

401

406

248

Male/female

195:206

192:214

143:105

0.026

Age

<0.0001

SBP (mmHg)

120

136

<0.0001

DBP (mmHg)

<0.0001

U-Prot (g/day)

0.20

1.00

1.31

<0.0001

eGFR (ml/min)

87.8

83.7

45.4

<0.0001

Observation period (years)

5.7

7.1

4.7

0.005

In clinical grading 1, Grade I, U-Prot<0.5 g/day; Grade II, eGFR≥60 ml/min and U-Prot≥0.5 g/day; Grade III, eGFR <60 ml/min and U-Prot≥0.5 g/day

Data of age, SBP, DBP, U-Prot, eGFR, and observation period are shown as median

SBP systolic blood pressure, DBP diastolic blood pressure, U-Prot, urinary protein, eGFR, estimated glomerular filtration rate

In grading 2, which further divided the patients with C-Grade I by the level of eGFR 60 ml/min/1.73 m², the number of patients with C-Grade Ia (eGFR ≧60 ml/min/1.73 m²) was 336 and C-Grade Ib (eGFR <60 ml/min/1.73 m²) was 65. The age was older and their blood pressure was higher in patients with C-Grade Ib compared with those with C-Grade Ia (Table 20.2).

Table 20.2

Patients characteristics according to the clinical grading 2

	C-Grade Ia	C-Grade Ib	C-Grade II	C-Grade III	P
Number of patients	336	65	406	248
Male/female	156:180	39:26	192:214	143:105	0.010
Age	29	56	31	51	<0.0001
SBP (mmHg)	118	130	120	136	<0.0001
DBP (mmHg)	70	79	72	80	<0.0001
U-Prot (g/day)	0.20	0.26	1.00	1.31	<0.0001
eGFR (ml/min)	92.7	49.4	83.7	45.4	<0.0001
Observation period (years)	5.6	5.7	7.1	4.7	0.013

In clinical grading 2, Grade Ia, eGFR≥60 and U-Prot<0.5 g/day; Grade Ib, eGFR<60 and U-Prot<0.5 g/day; Grade II, eGFR≥60 ml/min and U-Prot≥0.5 g/day; Grade III, eGFR <60 ml/min and U-Prot≥0.5 g/day

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