Validity of the Japanese Clinical Grade Criteria: Results from the Nationwide Retrospective Cohort Study in IgA Nephropathy

 

C-Grade I
C-Grade II
C-Grade III
P
Number of patients
401
406
248
 
Male/female
195:206
192:214
143:105
0.026
Age
30
31
51
<0.0001
SBP (mmHg)
120
120
136
<0.0001
DBP (mmHg)
71
72
80
<0.0001
U-Prot (g/day)
0.20
1.00
1.31
<0.0001
eGFR (ml/min)
87.8
83.7
45.4
<0.0001
Observation period (years)
5.7
7.1
4.7
0.005
In clinical grading 1, Grade I, U-Prot<0.5 g/day; Grade II, eGFR≥60 ml/min and U-Prot≥0.5 g/day; Grade III, eGFR <60 ml/min and U-Prot≥0.5 g/day
Data of age, SBP, DBP, U-Prot, eGFR, and observation period are shown as median
SBP systolic blood pressure, DBP diastolic blood pressure, U-Prot, urinary protein, eGFR, estimated glomerular filtration rate
In grading 2, which further divided the patients with C-Grade I by the level of eGFR 60 ml/min/1.73 m2, the number of patients with C-Grade Ia (eGFR ≧60 ml/min/1.73 m2) was 336 and C-Grade Ib (eGFR <60 ml/min/1.73 m2) was 65. The age was older and their blood pressure was higher in patients with C-Grade Ib compared with those with C-Grade Ia (Table 20.2).
Table 20.2
Patients characteristics according to the clinical grading 2
 
C-Grade Ia
C-Grade Ib
C-Grade II
C-Grade III
P
Number of patients
336
65
406
248
 
Male/female
156:180
39:26
192:214
143:105
0.010
Age
29
56
31
51
<0.0001
SBP (mmHg)
118
130
120
136
<0.0001
DBP (mmHg)
70
79
72
80
<0.0001
U-Prot (g/day)
0.20
0.26
1.00
1.31
<0.0001
eGFR (ml/min)
92.7
49.4
83.7
45.4
<0.0001
Observation period (years)
5.6
5.7
7.1
4.7
0.013
Jul 4, 2016 | Posted by in NEPHROLOGY | Comments Off on Validity of the Japanese Clinical Grade Criteria: Results from the Nationwide Retrospective Cohort Study in IgA Nephropathy

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