GSTP1

RASSF2

Urine (%)

Plasma (%)

Urine (%)

Plasma (%)

Positives (%)

Young asymptomatic males

6

20

37

2

Biopsy negative

59

31

82

16

All stages PCa

81

39

59

31

T1 (n = 47 U, 46 P)

83

37

96

35

T2 (n = 28 U, 25 P)

71

32

82

16

T3 (n = 7)

100

71

100

57

T4 (n = 2)

100

50

100

50

Median DNA (range), ng/ml

Young asymptomatic males

0 (0–0.07)

0 (0–0.00^a)

0 (0–0.09)

0 (0–0.00^a)

Biopsy negative

0.001 (0–0.15)

0 (0–0.02)

0.007 (0–0.70)

0 (0–0.04)

All stages PCa

0.008 (0–91.18)

0 (0–0.27)

0.025 (0–112.45)

0 (0–0.19)

T1 (n = 47 U, 46 P)

0.006 (0–91.80)

0 (0–0.18)

0.024 (0–112.45)

0 (0–0.19)

T2 (n = 28 U, 25 P)

0.008 (0–0.88)

0 (0–0.05)

0.022 (0–0.91)

0 (0–0.00^a)

T3 (n = 7)

0.029 (0.001–14.37)

0.001 (0–0.27)

0.042 (0–19.08)

0.0005 (0–0.02)

T4 (n = 2)

n.a. (0.014–0.14))

n.a. (0–0.00^a)

n.a. (0.07–0.08)

n.a. (0–0.00^a)

	HIST1H4K		TFAP2E
	Urine (%)	Plasma (%)	Urine (%)	Plasma (%)
Positives (%)
Young asymptomatic males	14	8	82	2
Biopsy negative	84	31	100	16
All stages PCa	92	31	100	18
T1 (n = 47 U, 46 P)	96	28	100	24
T2 (n = 28 U, 25 P)	82	28	100	4
T3 (n = 7)	100	71	100	29
T4 (n = 2)	100	0	100	0
Median DNA (range), ng/ml
Young asymptomatic males	0 (0–0.02)	0 (0–0.01)	0 (0–0.24)	0.013 (0–0.00a)
Biopsy negative	0.004 (0–0.16)	0 (0–0.00a)	0.052 (0.001–0.94)	0 (0–0.00a)
All stages PCa	0.008 (0–47.94)	0 (0–0.18)	0.096 (0.004–27.80)	0 (0–0.14)
T1 (n = 47 U, 46 P)	0.008 (0–47.94)	0 (0–0.18)	0.106 (0.01–27.80)	0 (0–0.14)
T2 (n = 28 U, 25 P)	0.008 (0–0.72)	0 (0–0.01)	0.096 (0.01–4.42)	0 (0–0.00a)
T3 (n = 7)	0.024 (0.00–4.04)	0.007 (0–0.02)	0.377 (0.01–6.81)	0 (0–0.01)
T4 (n = 2)	0 (0.01–0.06)	0	n.a. (0.08–0.09)	0

^aIndicates positive at >0.0001 ng/ml

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