Urethral Diverticulectomy


Leiomyoma

Skene’s gland abnormalities

Gartner’s duct abnormalities

Vaginal wall cysts

Urethral mucosal prolapse

Urethral caruncle

Periurethral bulking agents

Malignancy

Endometriosis



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Fig. 20.1
Skene’s gland abscess clinically (top) and on MRI (bottom)


Preoperative topical estrogen replacement in those with postmenopausal vaginal atrophy can be helpful in improving tissue quality .



Intraoperative Complications


Intraoperative complications related to anterior compartment vaginal surgery have been previously described and include, but are not limited to, bleeding and injury to the urinary tract.


Bleeding


The risk of bleeding during surgery can be minimized, but not entirely eliminated by good operative technique. Multiple blood vessels traverse the deep pelvis including large venous channels in the retropubic space. Named vessels in the obturator fossa along the pelvic sidewall, including branches of the internal iliac, and those vessels within the vascular pedicle of the bladder are at risk for injury, particularly during passage of trocars or needles for concomitant pubovaginal sling. Major vascular injury can quickly lead to life-threatening hemorrhage if not recognized intraoperatively and may result in large retropubic hematomas postoperatively [5, 6]. Bleeding during the harvest of a concomitant Martius flap is usually easily visualized and controlled with a combination of cautery, suture ligature, and direct compression. Labial hematomas have been reported with postoperative bleeding [7].

Bleeding during UD surgery can be problematic. The initial dissection of the vaginal flap from the underlying periurethral fascia should be associated with minimal bleeding. Bleeding encountered during this early dissection may indicate an excessively deep and incorrect surgical plane. In this circumstance, immediate recognition and reevaluation is necessary to avoid inadvertent entry into the urethral diverticulum or urinary tract and to minimize bleeding. Following identification of this situation, dissection should proceed in the proper surgical plane; in reoperative surgery, however, this may be difficult to identify.

Another common site of bleeding during transvaginal UD surgery occurs when traversing the endopelvic fascia for placement of a pubovaginal sling. Entry into the retropubic space from the transvaginal side or placement of the suprapubic needles or trocars from the abdominal side may be associated with copious bleeding as the endopelvic fascia is perforated. If the bleeding continues and is brisk, the vagina can be packed. It can be very helpful to manually elevate the anterior vaginal wall and compress it anteriorly against the posterior symphysis pubis for several minutes using the surgeon’s hand, sponge stick, or a retractor. These maneuvers will effectively tamponade bleeding in the retropubic space. Packing and compression will result in adequate control in the majority of cases; if not, the surgeon should expeditiously complete the procedure, close the incisions, and pack the vagina [8]. Additionally, absorbable sutures can be placed through and through the vaginal wall in the lateral fornices of the anterior vagina to ligate vessels that cannot be visualized in the operative field. Brisk bleeding that does not respond to manual compression for an extended period of time may suggest a major vessel injury and mandates retropubic exploration .


Urinary Tract Injury



Urethra


The Foley catheter is usually seen following complete excision of UD at the location of the entry of the ostium into the urethra. The urethra can be reconstructed over as small as a 14F Foley catheter without long-term risk of urethral stricture, and should be closed in a watertight fashion with absorbable suture [9]. The closure should be tension free. Uncommonly, a UD may extend circumferentially around the urethra and require transection of the involved portion of the urethra and complex reconstruction [10, 11].


Ureter


Ureteral injury during UD surgery is rare, but may occur with a large or proximal UD extending beyond the bladder neck and posterior to the bladder trigone. In these instances, cystoscopic placement of ureteric catheters prior to the dissection may aid in ureteral identification. Virtually all of these injuries can be identified by intraoperative cystoscopy. The administration of intravenous vital dyes such as indigo carmine permits obvious visualization of ureteral efflux confirming ureteral patency. With limited availability of indigo carmine, preoperative oral phenazopyridine, 50 % dextrose solution for bladder filling, or intraoperative intravenous 10% fluorescein can be used as alternatives [12, 13]. Suspected ureteral injuries are confirmed by retrograde pyeloureterography. Ureteral transection requires ureteroneocystostomy. Inadvertent ureteral obstruction by sutures can also be recognized with cystoscopic confirmation of ureteral patency. If obstruction is suspected, offending sutures can be identified and removed, and placement of a temporary indwelling ureteral stent should be considered.


Bladder


Intraoperative bladder injury may occur during dissection of a large UD extending proximal to the bladder neck and inferior to the bladder (Fig. 20.2), or alternatively, may occur with passage of a ligature carrier through the retropubic space if placing a pubovaginal sling.

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Fig. 20.2
Urethral diverticulum extending below trigone

Injury to the bladder during UD excision is diagnosed intraoperatively by careful endoscopic examination of the bladder and bladder neck with a 70° lens or a flexible cystoscope with retroflexion following UD dissection and/or passage of the ligature carrier. The bladder should be filled and then examined to ensure that a small injury does not go unrecognized in a fold of the bladder wall.

To avoid injury during ligature carrier passage, the urethra should be clearly palpated, the bladder drained, and the pelvic anatomy well delineated. If a bladder injury is noted intraoperatively, the ligature carrier should be removed and reinserted. Bladder perforation from a ligature carrier usually does not require primary closure.

Injury to the bladder floor during UD dissection requires cystoscopic examination to assess the extent of the injury and intravenous dyes should be administered to confirm ureteral integrity. Small cystotomies may be closed in layers with absorbable sutures transvaginally. More extensive injuries involving the trigone or more proximal bladder may require transabdominal repair. Postoperative drainage of the bladder with a Foley catheter will help avoid urinoma, fistula formation, and pelvic abscess.


Postoperative Complications


Careful adherence to the principles of transvaginal urethral diverticulectomy should minimize postoperative complications (Table 20.2). Nevertheless, complications may arise (Table 20.3). One small series suggested that large diverticula (>4 cm) or those associated with a lateral or horseshoe configuration may be associated with a greater likelihood of postoperative complications and risk factors for failure or poor functional outcome included horseshoe or circumferential configuration or a previous (failed) surgical intervention [14]. Large or more complex UD typically require greater dissection and more involved reconstruction.


Table 20.2
Principles of transvaginal urethral diverticulectomy





















Mobilization of a well-vascularized anterior vaginal wall flap(s)

Preservation of the periurethral fascia as a separate layer

Identification and excision of the neck of the UD or ostium

Removal of entire UD wall or sac (epithelium)

Watertight urethral closure

Multilayered, nonoverlapping closure with absorbable suture

Closure of dead space

Preservation or creation of continence


Data from Rovner ES. Bladder and Female Urethral Diverticula. In: Wein AJ, Kavoussi L, Novick A, Partin A, Peters C, eds. Campbell-Walsh Urology. 10th ed. Philadelphia: Elsevier Saunders; 2012



Table 20.3
Complications of transvaginal urethral diverticulectomy

























Complication (% range of reported incidence)

Urinary incontinence (1.7–16.1 %)

Urethrovaginal fistula (0.9–8.3 %)

Urethral stricture (0–5.2 %)

Recurrent UD (1–25 %)

Recurrent UTI (0–31.3 %)

Other

Hypospadias/distal urethral necrosis

Bladder or ureteral injury

Vaginal scarring or narrowing: dyspareunia, etc.


Data from Dmochowski R. Surgery for vesicovaginal fistula, urethrovaginal fistula, and urethral diverticulum. In: Walsh P, Retik A, Vaughn Jr. E, Wein A, eds. Campbell’s Urology. 8th ed. Philadelphia: WB Saunders; 2002


Early Postoperative Complications


Raup and coworkers described 30 day complications of diverticulectomy in the multi-institutional cohort derived from the National Surgical Quality Improvement Program user files. They found that out of 2.3 million cases in the database, there were 122 female urethral diverticulectomy cases reported between 2007 and 2012. Minor complications occurred in 3.3 % of cases, with urinary tract infection being most common (four patients), and one each of superficial wound infection and hemorrhage requiring transfusion [15]. Nickles and coworkers report a series of 43 patients who underwent urethral diverticulectomy with UTI rates of 3/11 (27 %) for complex UD, and 1/32 (3 %) for simple UD [16]. In a series of 38 patients undergoing autologous rectus fascial pubovagninal sling and UD repair, Enemchukuwu and coworkers report a 5 % (2/38) rate of wound infection, presumably at the harvest site [17].


Incontinence



Stress Urinary Incontinence


Patients with preoperative symptomatic stress urinary incontinence (SUI) in association with UD can be offered simultaneous anti-incontinence surgery. Preoperative videourodynamics may be helpful in evaluating the anatomy of the UD, assessing the competence of the bladder neck, and confirming the diagnosis of SUI. In patients with SUI and UD, Ganabathi and others have described excellent results with concomitant needle bladder neck suspension [9, 18], although such needle suspensions are rarely done in contemporary practice. More recently, pubovaginal autologous fascial slings have been utilized in patients with UD and SUI with satisfactory outcomes [1, 17, 19, 20]. The role of synthetic midurethral slings, however, has not been well defined in this population and current AUA guidelines recommend against using synthetic material in this setting [21]. Placement of synthetic material adjacent to a fresh suture line following diverticulectomy in the setting of potentially infected urine may place the patient at higher risk for subsequent urethral erosion and vaginal extrusion of the sling material as well as urethrovaginal fistula formation and foreign body granuloma formation [21].

Significant postoperative de novo SUI may occur in between 7 and 16 % of individuals undergoing urethral diverticulectomy surgery without a concomitant anti-incontinence surgery [7, 22, 23]. However, Lee and colleagues noted at least minor de novo SUI in 49 % of patients following urethral diverticulectomy, the majority of which was minor and did not require additional therapy [24]. Only 10 % of these individuals underwent a subsequent SUI operation. Risk factors for de novo SUI may include the size of the diverticulum (>30 mm) and more proximal location [23]. Ljungqvist and colleagues correlated de novo SUI with wide diverticulum excision in addition to size and location [7]. Popat and Zimmern [25] reported long-term follow-up for 12 women with horseshoe diverticula who underwent diverticulectomy using a urethral preservation technique. Four patients had stress incontinence preoperatively, two had residual stress incontinence, one went on to have treatment with collagen injection [25]. Nickles and coworkers report de novo SUI in 1/11 (9.1 %) after complex UD repair and 1/32 simple UD repairs, noting a significantly higher rate of concomitant PV sling with complex repair [16]. De novo SUI may arise from the extensive suburethral or circumferential dissection required for a large UD, and the more proximal UD location may compromise the urethral sphincter and bladder neck anatomical support and/or the sphincter mechanism [23]. Alternatively, large UD at the bladder neck may cause obstruction [26] and occult SUI may be unmasked after removing the obstructing UD [27].

Management of de novo postoperative SUI is undertaken after allowing postsurgical inflammation to subside. Autologous pubovaginal sling is a reasonable option in this setting. Synthetic materials such as midurethral polypropylene slings must be used judiciously in this setting, however, as safety data are lacking. Repeat preoperative imaging may be helpful in excluding a recurrent or persistent UD, or urethrovaginal fistula prior to surgery for incontinence [7].

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Jun 30, 2017 | Posted by in UROLOGY | Comments Off on Urethral Diverticulectomy

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