© Springer International Publishing AG 2018
Patrick Lowry and Kristina L. Penniston (eds.)Nutrition Therapy for Urolithiasishttps://doi.org/10.1007/978-3-319-16414-4_1111. Therapeutic Nutritional Strategies When No Risk Factors Are Apparent
(1)
Texas A&M University College of Medicine, Temple, TX, USA
(2)
Division of Urology, Baylor Scott and White Healthcare, Texas A&M University College of Medicine, Scott & White Memorial Hospital, 2401 S 31st Street, Temple, TX 76508, USA
Introduction
Recurrent urolithiasis are a significant cause of morbidity and discomfort. Not only are they painful, but they also result in repeated expensive and sometimes invasive medical interventions. In some patients, a treatable cause is diagnosed, which can result in a significant reduction in clinically significant urolithiasis. However, in roughly 15–20% of calcium oxalate stone formers, no specific cause can be identified [1, 2]. Given that kidney stones affect 0.5–1% of the population per year in the United states and that up to 80% of these are calcium oxalate stones, idiopathic stone formers comprise a significant portion of the population [3, 4]. Formulating a treatment plan for these patients, in whom no correctable cause is identified, presents a unique challenge.
In this chapter, risk factor identification for idiopathic stone formers (i.e. those with no identifiable risk factors on lab testing) will be discussed, as well as dietary strategies for avoiding stones in these patients.
Diagnosis
In this patient population, a complete history and workup focused on stone risk factors presumably revealed no underlying cause, yet the patient continues to experience repeated episodes of stones [5–7]. Patients should also be questioned about professional and recreational activities that occur in a hot environment or are associated with excessive sweating and may decrease urine output even in the context of sufficient fluid intake [8]. Furthermore, a 7 day diet and fluid intake diary may reveal dietary risk factors impacting stone formation, which will be discussed later. Tracking their diet for 7 days has the added benefit of drawing patients’ attention to their consumption of certain foods associated with stone formation or, more importantly, a paucity of fluid intake.
Patients who have repeated stones will have a workup including at least one 24 h urine collection [6]. However, a 24 h urine with normal values does not account for the possibility that stone risk may increase before levels of some metabolites cross the threshold into the abnormal range. Additionally, some patients may, either intentionally or unintentionally, be more adherent to their prescribed dietary interventions during their 24 h urine collection. For this reason, it is recommended that a urinalysis be done on a different day than the 24 h urine collection. The urinalysis osmolality can then be compared to the osmolality and volume collected during the 24 h urine collection. If these values do not correlate, a clinician can consider the possibility that the 24 h urine collection may not be representative of the patient’s usual daily fluid intake or urine output. Urine Osmolality may not be easily obtainable, and urine specific gravity may be used instead. The laboratory test results should also be compared with the diet and fluid intake reported during the history. Together, these results may be used to further educate the patient and improve their chances of remaining stone-free.
It is important to individualize a patient’s diet to improve their chances of remaining stone free [7]. Patient characteristics and diet can vary widely and because so many factors contribute to stone risk, it is important to determine what, if any dietary interventions might be beneficial. In attempting dietary remediation of urolithiasis, it is important to understand that dietary interventions can be challenging for patients to implement and can lead to expectations that might outweigh the benefits the patients receive. Thus, dietary interventions should be considered carefully and it is important to explain to patients the benefits that might reasonably be expected from each intervention. Additionally, dietary counseling that addresses too many issues at once may result in lifestyle changes that the patient perceives as complex, which may result in noncompliance. Rather than address every risk factor at once, we prefer to simplify patient instructions, and prioritize counseling the patient on only the most important factor or two, in order to maximize compliance. The remaining causes are addressed during follow up visits after additional 24 h urine testing is performed.
Nutritional Strategies
Risk factors may be uncovered in a diet history or 24 h urine collection. Such risk factors include low fluid intake resulting in low urine volume, imbalances in calcium, oxalate, or other key nutrients. This section outlines and explains these risk factors and considers possible interventions to address them. Keep in mind that the subset of patients discussed in this section have no identifiable risk factors. We do not recommend nutrition therapy that is not warranted, but instead we propose to maximize urinary parameters according to available evidence in order to minimize the risk of stone formation. The authors believe that although 24 h urine tests in these patients are within normal limits on the day of the evaluation, it is highly likely that the variability of food intake from day to day results in some days with low risk and other days with high risk of stone formation [9]. During these days of high risk, crystals may form, and propagate over time.
Fluid Intake
Patients with a normal workup may still need to increase their fluid intake [5, 8, 10]. As mentioned previously, patients may behave differently on the day of their workup and may not maintain a sufficient fluid intake to prevent stones on a daily basis. Furthermore, there is evidence that patients who have a history of stone formation have a higher risk of forming stones at a given urine volume compared to individuals who do not form stones. Thus, patients with a normal workup and a propensity to form stones should still be advised to increase fluid intake. Evidence suggests that in stone formers, stone risk increases dramatically when urine volume drops below 1.6 L/day. To minimize stone risk according to the AUA guidelines , patients should drink sufficient liquid to excrete a urine volume of roughly 2.5 L/day [5]. If stones still recur at this urine volume, fluid intake may need to be increased further in order to increase urine output to 3 L/day, or even higher if stones continue to recur [8].
Individuals attempting to increase fluid consumption to diminish stone risk should also be counseled on the type of liquids that may best mitigate risk factors. Patients should focus on increasing fluid intake, while recognizing that the fluid of most beverages will lower risk more than the hypothetical increased risk of the contents of some beverages. Additionally, it may be worthwhile to counsel patients regarding the content of calcium and other minerals in the water a patient drinks. While there is insufficient evidence that individuals who drink hard water have a higher risk of stones, patients commonly ask about their water source and its potential effect. Rodgers showed that in stone formers, ingestion of a mineral water rich in calcium and magnesium showed beneficial parameters on a 24 h urine test compared to tap water [11]. Schwartz et al. reviewed 4,833 stone formers by zip code, and used the zip code to stratify patients by water hardness based on information provided by the Environmental Protection Agency. No difference on lifetime stone episodes was detected in regions with hard or soft water, although 24 h urine calcium, magnesium, and citrate levels were higher in the hard water regions [12].
Observational studies have shown a decreased risk of stone formation with increased consumption of tea, coffee, decaffeinated coffee, and alcoholic beverages [13, 14]. Curhan et al. demonstrated in a prospective trial a decreased risk of stone formation with intake of both caffeinated and decaf coffee (10%), tea (14%), beer (21%) and wine (39%). This information is important to share with patients as many practitioners incorrectly counsel that coffee and tea increase stone risk through their oxalate content. Finally, patients should be advised to avoid drinking fluids that may increase their risks of forming stones. Drinks associated with a higher risk of stones include those flavored with high sugar content. Schuster et al. showed that stone formers who simply abstained from drinking sugar sweetened soft drinks decreased their incidence of stone formation by 7% [23]. Additionally, Ferraro revealed that patients who drank one or more sugar sweetened sodas per day had a 23% increased risk of stone formation, and those who ingested one or more sugar sweetened non soda beverages had an increased risk of 33% [14].
Patients may struggle to adhere to the recommendations for increased fluid intake. Some patients may have lifestyles or professions that make high-volume liquid consumption or frequent trips to the restroom difficult [8]. Additionally, patients with colitis, Crohn’s disease , or other bowel disorders may have difficulty maintaining urine output due to gastrointestinal fluid losses, and often require input from Gastroenterology colleagues to better manage the chronic diarrhea [15].
Timing of fluid intake may help prevent stones. Although it may result in nocturia, drinking before bedtime prevents dehydration form the lack of fluid intake. Stone formers would not go 6–8 h without fluid intake in the daytime, so they need to drink enough to stay hydrated at night. Otherwise, the relative dehydration at night caused by poor fluid intake results in an increased risk of crystallization of stone forming constituents. If nocturia presents a barrier to nighttime fluid intake, patients may need further Urologic evaluation to improve this condition.
Dietary Oxalate
High urine oxalate is a risk factor for the formation of calcium oxalate stones [5, 8, 16]. However, dietary intake of oxalate is a controversial risk factor for stone formation. There is some evidence that dietary oxalate contributes to stone formation, however there is limited evidence that limiting dietary oxalate decreases stone risk. This is because dietary oxalate may not be bioavailable and therefore may not be readily absorbed. Oxalate that is in crystal or precipitated forms, which is what is typically found in food, is less likely to be absorbed. In patients with normal 24 h urinary oxalate levels, restriction of dietary oxalate is unlikely to significantly affect stone risk. However, if the oxalate level is borderline high and the patient persists in forming calcium oxalate stones, per the AUA guidelines, a mild oxalate restriction combined with maintaining normal calcium may help decrease the risk of future stone formation [6]. In spite of the fact that dietary oxalate may not be bioavailable, there may be other dietary sources of urine oxalate. Several oxalate precursors, including hydroxyproline and ascorbic acid, may be found in the diet and could contribute to oxalate excretion .