The Female Patient


1. Conservative

(a) Bladder training

2. Anticholinergics (antimuscarinics)

(a) Non-uroselective

 i. Oxybutynin

   ii. Propantheline

(b) Uroselective

 i. Solifenacin

   ii. Darifenacin

iii. Fesoterodine

iv. Trospium

   v. Propiverine

3. Surgical

(a) Botulinum toxin A

(b) S3 sacral neuromodulation

(c) Percutaneous tibial nerve stimulation

(d) Augmentation cystoplasty

(e) Detrusor myomectomy

(f) Urinary diversion


References

Abrams P. Describing bladder storage function: overactive bladder syndrome and detrusor ­overactivity. Urology. 2003;62(5 Suppl 2):28–37; discussion 40–2

Apostolidis A. Neuromodulation for intractable OAB. Neurourol Urodyn. 2011;30(5):766–70

Duthie JB, Vincent M, Herbison GP, Wilson DI, Wilson D. Botulinum toxin injections for adults with overactive bladder syndrome. Cochrane Database Syst Rev. 2011;(12)

Gulur DM, Drake MJ. Management of overactive bladder. Nat Rev Urol. 2010;7(10):572–82



Treatment options for drug-refractory detrusor overactivity include intravesical botulinum toxin A injection (see Chap. 6), which has been shown to reduce incontinence episodes and increase functional bladder capacity but needs to be repeated (Duthie et al. 2011). Neuromodulation techniques include acupuncture, tibial nerve neuromodulation, and S3 sacral neuromodulation. (Apostolidis A, 2011). Other (surgical) options less commonly employed to lower bladder storage pressures in very symptomatic patients include detrusor myomectomy and augmentation cystoplasty (Table 4.1).



Tips 4.1: How to Do Bladder Training


Bladder training is a structured program which involves educational and behavioral intervention to reestablish bladder control in adults. The aim is to increase functional bladder capacity which should then reduce frequency, urgency and nocturia and improve quality of life.

Bladder training may be used in combination with antimuscarinic agents. The patient needs to be cognitively sound and physically able and has a desire to regain bladder control. Initial assessment is to identify patients’ continence needs, gaps, and behavior that can be modified. A complete training program takes 3–6 months with the possibility of extending it to 12 months.

A typical bladder training program:



  • Establish a short-term achievable goal based on the 3-day voiding/incontinence diary. Discuss long-term patient-specific expectation and goals. Encourage patient to focus on achieving small improvements in bladder capacity. This strategy helps to develop more confidence in bladder control. For example, increase functional bladder volume by 50 ml with effective application of deferment technique.


  • Modify fluid and fiber intake. Assess pattern of food and fluid consumption to identify areas (e.g., high caffeinated beverages) that need modification. Promote optimal body weight and regular bowel motion achieving Bristol Stool Scale 3–4 (see Appendix A).


  • Patient applies specific deferment technique to prolong voiding intervals during the day with 30-min increments, gradually increasing functional bladder capacity and reducing urine frequency.


  • Apply biofeedback strategies to control bladder urgency and reduce incidence of urge incontinence. Pelvic floor muscle training (PFMT) may be helpful in abolishing overactive detrusor contractions and controlling urgency


  • It may take some time for the patient to develop confidence to overcome long-standing unsatisfactory toileting habits.


  • Program is tailored to individual needs and limitations.

References

Roe B OJ, Milne J, Wallace S. Systematic reviews of bladder training and voiding programs in adults: a synopsis of findings from data analysis and outcomes using metastudy techniques. J Adv Nurs. 2007;57(1):15–31.

Wallace SA, Roe B, Williams K, Palmer M. Bladder training for urinary incontinence in adults. Cochrane Database Syst Rev. 2004:CD001308.



Case 4.2


A 45-year-old lady presents with a 3-year history of worsening stress urinary ­incontinence. She reports leakage with coughing, lifting, and running. She needs to use at least three medium pads a day and is very bothered by her incontinence. She has had two children by vaginal delivery.



Q: What features in the history and physical examination are of particular ­importance in this case?



A: Associated urgency or urgency incontinence, pad usage, degree of bother, and its effect on quality of life (QoL) which can be assessed using QoL questionnaires (see Table 4.2), pelvic floor exercises and duration, and weight control. Physical examination to palpate bladder, exclude neurological signs, vaginal examination to assess degree of estrogenization, and assess for pelvic organ prolapse.


Table 4.2
Commonly used QoL questionnaires for incontinence















1. International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF)

2. Incontinence Quality of Life Questionnaire (I-QoL)

3. Kings’ Health Questionnaire (KHQ)

4. Urinary Distress Inventory and Incontinence Impact Questionnaire (UDI-6 and IIQ-7)

5. Short Form 36 (SF-36)



Q: Does she need any other investigations before starting conservative treatment?



A: Urine microscopy/culture, post-void residual urine, and body mass index (BMI) (Table 4.3). If these are within normal limits, then pelvic floor muscle training (PFMT) can be instituted for treatment of stress urinary incontinence, in conjunction with reduction in abdominal strain if indicated, e.g., weight loss and control of chronic airway disease such as asthma. (Tips 4.2)


Table 4.3
American Urological Association guidelines for management of female SUI: summary of assessment (Dmochowski et al. 2010)















1. Focused history

2. Physical examination and demonstration of leakage with increased abdominal pressure

3. Post-void residual urine

4. Midstream urine or urinalysis

5. Other diagnostic modalities if indicated (cystoscopy, imaging, urodynamics)

Topical estrogen therapy may improve symptoms of overactive bladder and urge incontinence by its effect on atrophic vaginitis. However, estrogen treatment alone has limited effects on stress urinary incontinence. There may be a role as adjunctive treatment prior to surgery for stress incontinence or pelvic organ ­prolapse.



Q: What other nonsurgical options can be offered if conservative treatment fails?



A: Pessaries and continence aids

There are two types of devices, intraurethral and intravaginal devices, available for women with mild to moderate stress incontinence who wish to consider this nonsurgical management option.

Both types of devices are suitable for women with good cognition and adequate manual dexterity to periodically remove and replace the device. Patients are usually referred to a nurse or physiotherapist specialized in intravaginal therapy for urinary incontinence and pelvic organ prolapse. Speculum examination of the vagina is necessary to confirm satisfactory degree of estrogenization before going for trial of a continence device. Patients should receive proper training and support to gain confidence in caring for the device. (McIntosh L, 2005).

1.

Intraurethral device – The disposable urethral device is small and requires manipulation for insertion and removal. It is a temporary option for younger women who want to achieve social continence. There is limited data regarding its use. Common complications for this group include device displacement into the bladder or related infection. Overall, evidence is weak in support of effectiveness of intraurethral devices.

 

2.

Intravaginal devices include tampon, pessaries, and bladder neck support. An intravaginal device is inserted into the vagina to support the urethra or the bladder neck before physical activities in order to reduce the degree of stress incontinence. Selection of a properly fitted device for trial is essential. Patients need to be well supported and educated in the application and care of the device. (Allen et al. 2008).

 

This patient remains bothered by her stress incontinence despite 6 months of pelvic floor physiotherapy. She is keen to undergo surgical treatment.



Q: Would urodynamic study (UDS) be beneficial preoperatively?



A: This is an area of controversy. Many clinicians would perform UDS to assess detrusor function, confirm the presence of urodynamic SUI, and exclude voiding dysfunction before recommending a suitable type of sling or other options preoperatively. This is mainly because urinary symptoms may not be indicative of the underlying pathophysiological condition(s). This is especially true in the elderly when multiple medical comorbidities often exist (see Chap. 6) and contribute to urinary incontinence. While UDS may not change the decision to proceed to surgery, findings of OAB or voiding dysfunction may allow the surgeon to better consent the patient regarding potential complications and tailor the surgical procedure to optimize clinical outcome. Although some studies have shown that in clinical cases of “pure” symptomatic stress incontinence UDS may not affect clinical outcome, it should be noted with a caveat that “pure” stress incontinence cases are uncommon and some of these patients in fact have detrusor overactivity or other bladder dysfunction at UDS without SUI. Hence, in general, UDS are recommended before surgery especially in the presence of mixed stress and urgency incontinence.



Q: What are the key points to note in surgical options?



A: Stress incontinence operations can be broadly classified into slings, suspension procedures, and injectable bulking agents. Slings provide support to the urethra/closure mechanism at times of exertion and can be synthetic or biological. Synthetic suburethral slings (Fig. 4.2) are commonly placed at the midurethra for patients with SUI associated with urethral hypermobility but may also be used in selected patients with more severe incontinence related to intrinsic sphincter deficiency (ISD) (Kleeman et al. 2011). The pubovaginal sling utilizes autologous fascia from the rectus sheath placed at the level of the proximal urethra and is commonly used for patients with severe incontinence related to ISD but can also be used in patients with urethral hypermobility or in patients who do not desire synthetic material (Athanasopoulos et al. 2011). Transurethral injection of bulking agents (Fig. 4.3) (e.g., Macroplastique® – silicone elastomer, Bulkamid® – polyacrylamide, Durasphere® – carbon beads) has a less important role nowadays and is often reserved for more frail patients with ISD (see Chap. 6). Suspension procedures such as Burch colposuspension and needle suspensions are now rarely performed and superseded by the less invasive midurethral slings in general. Other surgical treatments (rarely performed) include the artificial urinary sphincter (see Chap. 5) which may have a role in patients who have significant ISD and generally have failed at least one of the above treatments.

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Fig. 4.2
(a, b) Suburethral synthetic sling (retropubic) – the sling provides support to the midurethra at times of exertion such as coughing or abdominal straining (b)

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Jul 5, 2017 | Posted by in UROLOGY | Comments Off on The Female Patient

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