Despite advances in care, most patients with Crohn’s disease (CD) develop complications, such as fistulas, or require surgery. Given the recent advances in drug therapy, an opportunity exists to optimize the management of this chronic disease through early use of effective therapies, clear definition of treatment targets, and application of the principles of personalized medicine. In this article, the authors discuss the evolution of treatment algorithms for CD to incorporate these strategies.
Key points
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Several new and effective therapies are available for the treatment of Crohn’s disease.
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Recent clinical guidelines have advocated for the use of objective markers of inflammation in addition to clinical symptoms to assess response to therapy.
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Early use of effective therapies, prognostication to identify high-risk patients, objective end points, precision medicine, pharmacokinetic/pharmacodynamics factors, and frequent assessment of disease activity are key features of a new treat-to-target algorithm.
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