Surgical Treatment of Obesity and Diabetes




Sleeve gastrectomy, gastric bypass, gastric banding, and duodenal switch are the most common bariatric procedures performed worldwide. Ninety-five percent of bariatric operations are performed with minimally invasive laparoscopic technique. Perioperative morbidities and mortalities average around 5% and 0.2%, respectively. Long-term weight loss averages around 15% to 25% or about 80 to 100 lbs (40–50 kg). Comorbidities, including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, arthritis, gastroesophageal reflux disease, and nonalcoholic fatty liver disease, improve or resolve after bariatric surgery.


Key points








  • Sleeve gastrectomy, gastric bypass, gastric banding, and duodenal switch are the most common bariatric procedures performed worldwide.



  • Ninety-five percent of bariatric operations are performed with minimally invasive laparoscopic technique.



  • Perioperative morbidities and mortalities average around 5% and 0.2%, respectively.



  • Long-term weight loss averages around 15% to 25% or about 80 to 100 lbs (40–50 kg).



  • Comorbidities, including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, arthritis, gastroesophageal reflux disease, and nonalcoholic fatty liver disease, improve or resolve after bariatric surgery.






Introduction


Bariatric surgery has evolved since the 1950s and has proven to be the most effective long-term treatment for the chronic disease known as obesity. Furthermore, it also has been shown to resolve or significantly improve many of the metabolic disorders related to obesity, especially type 2 diabetes (T2D). These gastrointestinal procedures have resulted in resolution of obesity-related comorbidities through weight loss, neuroendocrine, or hormonal mechanisms. Thus, the term bariatric surgery is now frequently replaced with metabolic surgery. A complete understanding of all the mechanisms of metabolic surgery is yet to be determined. It is known, however, that the alteration of the gastrointestinal tract by reducing stomach capacity and nutrient absorption in the small intestine alters the satiety, calorie absorption, and neuroendocrine pathways, leading to sustained weight loss and resolution of T2D.


The laparoscopic technique of bariatric/metabolic surgery was started in the early 1990s, and currently, almost 95% of these metabolic procedures are performed laparoscopically worldwide. The laparoscopic approach significantly reduces perioperative morbidity, mortality, recovery time, and cost. In 2015, a total of 196,000 bariatric/metabolic procedures were performed in the United States, and sleeve gastrectomy (SG) was the commonest metabolic procedure (53.8%). Other metabolic procedures were Roux-en-Y gastric bypass (RYGB), 23.1%; laparoscopic adjustable gastric band (LAGB), 5.7%; biliopancreatic diversion with or without duodenal switch (BPD ± DS), 0.6%; and revisional and other procedures, 16.8%.


Bariatric surgery was initially introduced as weight-loss surgery for the treatment of severe obesity. Obesity is most commonly measured based on body mass index (BMI), which has been used as the primary indication for bariatric surgery. The 1991 National Institutes of Health (NIH), 2013 American College of Cardiology/American Heart Association Task Force, and The Obesity Society (TOS) have similar guidelines for bariatric surgery referral: BMI greater than or equal to 40 kg/m 2 or BMI greater than or equal to 35 kg/m 2 with obesity-related comorbidities. It is becoming increasingly evident that BMI itself is not necessarily a strong marker for obesity-related illness or future cardiovascular risk. It appears that fat distribution and quantity of visceral fat rather than BMI alone convey the major risk factors for obesity. Metabolic surgery in patients with T2D should be tailored based on the class of obesity and inadequate glycemic control despite optimal medical treatment. Based on strong evidence from randomized trials, metabolic surgery was recently recommended in the treatment algorithm for T2D in the 2nd Diabetes Surgery Summit (DSS-II).




Introduction


Bariatric surgery has evolved since the 1950s and has proven to be the most effective long-term treatment for the chronic disease known as obesity. Furthermore, it also has been shown to resolve or significantly improve many of the metabolic disorders related to obesity, especially type 2 diabetes (T2D). These gastrointestinal procedures have resulted in resolution of obesity-related comorbidities through weight loss, neuroendocrine, or hormonal mechanisms. Thus, the term bariatric surgery is now frequently replaced with metabolic surgery. A complete understanding of all the mechanisms of metabolic surgery is yet to be determined. It is known, however, that the alteration of the gastrointestinal tract by reducing stomach capacity and nutrient absorption in the small intestine alters the satiety, calorie absorption, and neuroendocrine pathways, leading to sustained weight loss and resolution of T2D.


The laparoscopic technique of bariatric/metabolic surgery was started in the early 1990s, and currently, almost 95% of these metabolic procedures are performed laparoscopically worldwide. The laparoscopic approach significantly reduces perioperative morbidity, mortality, recovery time, and cost. In 2015, a total of 196,000 bariatric/metabolic procedures were performed in the United States, and sleeve gastrectomy (SG) was the commonest metabolic procedure (53.8%). Other metabolic procedures were Roux-en-Y gastric bypass (RYGB), 23.1%; laparoscopic adjustable gastric band (LAGB), 5.7%; biliopancreatic diversion with or without duodenal switch (BPD ± DS), 0.6%; and revisional and other procedures, 16.8%.


Bariatric surgery was initially introduced as weight-loss surgery for the treatment of severe obesity. Obesity is most commonly measured based on body mass index (BMI), which has been used as the primary indication for bariatric surgery. The 1991 National Institutes of Health (NIH), 2013 American College of Cardiology/American Heart Association Task Force, and The Obesity Society (TOS) have similar guidelines for bariatric surgery referral: BMI greater than or equal to 40 kg/m 2 or BMI greater than or equal to 35 kg/m 2 with obesity-related comorbidities. It is becoming increasingly evident that BMI itself is not necessarily a strong marker for obesity-related illness or future cardiovascular risk. It appears that fat distribution and quantity of visceral fat rather than BMI alone convey the major risk factors for obesity. Metabolic surgery in patients with T2D should be tailored based on the class of obesity and inadequate glycemic control despite optimal medical treatment. Based on strong evidence from randomized trials, metabolic surgery was recently recommended in the treatment algorithm for T2D in the 2nd Diabetes Surgery Summit (DSS-II).




Patient selection for metabolic surgery


Indications for bariatric surgery are based on the historic 1991 NIH Consensus Guidelines. These guidelines focused primarily on surgery as treatment of severe obesity, but not necessarily for those with T2D and obesity-related metabolic diseases. In general, patients with chronic obesity and BMI greater than or equal to 40 or BMI greater than or equal to 35 with comorbidity are candidates for surgery if they are psychologically stable and have no active substance abuse. Recently, the DSS-II in collaboration with 6 International Diabetes Organizations published a joint statement on the treatment algorithm for T2D using metabolic surgery. This joint statement was endorsed by 45 leading professional societies worldwide (including both medical and surgical organizations). The indications and contraindications for metabolic surgery are shown in Table 1 .



Table 1

Indications and contraindications for surgery to treat type 2 diabetes









Indication (BMI depends on patients’ ancestry; Asians: BMI should be reduced by 2.5 kg/m 2 )


  • Recommended in:




    • T2D patients with class III obesity (BMI ≥40 kg/m 2 ); regardless of glycemic control or complexity of glucose-lowering regimes



    • T2D patients with class II obesity (BMI 35–39.9 kg/m 2 ) with inadequate glycemic control despite lifestyle and optimal medical treatment (either oral or injectable medications including insulin)




  • Considered in:




    • T2D patients with class I obesity (BMI 30–34.9 kg/m 2 ) with inadequate glycemic control despite optimal medical treatment (oral or injectable medications, including insulin)



    • The patient must be psychiatrically stable


Contraindication


  • Relative contraindication




    • High risk of surgical complication due to poor health



    • Inability or unwillingness to change lifestyle postoperatively



    • Uncommitted to long-term follow-up and nutritional supplementation postoperatively



    • Addicted to drugs or alcohol



    • Psychologically unstable




Metabolic surgery should be performed in high-volume centers with a multidisciplinary team (including the surgeon, endocrinologist/diabetologist, and dietician with expertise in diabetes care). Other relevant specialists should be considered depending on the patients’ circumstances.


Preoperative evaluation of these patients includes a complete medical history, psychological history, nutritional assessment, physical examination, and investigations to assess surgical risk for metabolic surgery (endocrine, metabolic, nutritional, and psychological assessments). In 2008, American Association of Clinical Endocrinologists (AACE), TOS, and American Society for Metabolic and Bariatric Surgery (ASMBS) published clinical practice guidelines (CPG) for perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patients, which was recently updated in 2013. Patients should have a comprehensive preoperative assessment of all comorbid conditions. For patients with diabetes, they should be counseled regarding frequent postoperative monitoring of glycemic control, diabetic complications (diabetic ketoacidosis or hypoglycemia), the likelihood of diabetes remission, and complementary medical therapy.


The choice of the metabolic procedure is based on the risk-to-benefit-ratio evaluation for each patient. Long-term postoperative complications of surgery versus effectiveness of glycemic and cardiovascular risk should be discussed with each patient as part of informed consent. Currently, 4 procedures constitute most bariatric operations globally: SG, RYGB, LAGB, and BPD + DS ( Fig. 1 ).




Fig. 1


Common metabolic procedures.

( Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2006-2016. All Rights Reserved.)




Technique of the procedures


Patient preparation in the operating room is summarized in Table 2 . The position of the operating surgeon and the assistant is as shown in Figs. 2 , and 3 shows the port placement for all the bariatric procedures in the authors’ center.



Table 2

Patient preparation (in operation room)












Positioning


  • Supine position with the feet together on a footboard



  • Heavy tape is used to secure the patient’s legs to the bed above and below the knees to prevent the knees from bending when the patient is in full reverse Trendelenburg position

Prophylactic antibiotics


  • First-generation cephalosporin or an appropriate alternative in patients allergic to penicillin

VTE prophylaxis


  • Intermittent pneumatic compression devices are applied to lower limb



  • Intraoperative chemoprophylaxis




Fig. 2


Positioning for laparoscopic surgery. In the authors’ center, the operating surgeon stands on the patient’s right side and the assistant stands on the left for all bariatric procedures. Monitors are placed on both sides of the table over the patient’s shoulder.

( Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2006-2016. All Rights Reserved.)



Fig. 3


Port placement. Pneumoperitoneum: Established with a Veress needle through a left upper quadrant incision. Visual access to the peritoneal cavity: Use a 5-mm optical viewing trocar, and the remaining 5 ports are placed under direct vision. Ports placement for all bariatric procedures is as shown. If there are severe adhesions to the abdominal wall from a prior laparotomy, an additional 5-mm trocar is placed in the left lower quadrant to create an adequate working space for the remaining ports.

( Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2006-2016. All Rights Reserved.)


Approach


Liver retraction


A 5-mm liver retractor (Snowden-Pencer, Tucker, GA, USA) is placed through the right lateral port and anchored to the bed with a self-retaining device. A Nathanson liver retractor can also be used in the subxiphoid position and, for larger patients with extremely big or floppy left hepatic lobes, both retractor systems can be used simultaneously to achieve adequate exposure of the gastroesophageal junction.


Operative Procedures


Sleeve gastrectomy





  • Mobilize the omentum at stomach’s greater curvature from the angle of His all the way down to the pylorus using the ultrasonic dissector device.



  • Create stomach tube ( Fig. 4 A ).




    • Once the stomach is fully mobilized, apply a 60 mm load stapler approximately 3 cm to the pylorus, parallel to the lesser curvature. An endoscope is passed down along the lesser curvature of the stomach and into the pylorus. Continue to fire 60 mm load staplers parallel to the endoscope up toward the angle of His.




    Fig. 4


    The laparoscopic SG. ( A ) Creating a narrow gastric tube over a bougie or endoscope using a linear cutting stapler to excise the stomach body and fundus. ( B ) The final anatomic arrangement after a SG.

    ( Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2006-2016. All Rights Reserved.)



  • Oversewn stapler lines




    • The long stapler lines are oversewn with running a 2-0 absorbable suture in a Lembert fashion all the way down to the pylorus. Alternatively, some surgeons will reinforce the staple line with a synthetic buttressing material or provide no additional reinforcement. Fig. 4 B shows the final anastomotic arrangement after SG.




  • Leak test




    • With the scope in place, insufflation of stomach is performed to test for air leaks and narrowing.




  • Schauer’s cap




    • An omental patch is placed over the anastomosis and secured with 2-0 nonabsorbable suture.




  • Liver biopsy




    • A core needle liver biopsy using an 18-G needle is performed routinely as part of every bariatric procedure to document the severity of nonalcoholic fatty liver disease (NAFLD).




  • Drain (optional)




    • A round Jackson-Pratt (JP) drain is placed alongside the staple/suture line and brought out through the right upper quadrant port site.




  • Specimen retrieval (SG)




    • A remnant stomach specimen is removed using a sterile bag.




  • Port closure




    • Close fascia at the 12-mm port sites with absorbable suture using a suture-passer.




  • Skin closure




    • All instruments and trocars are removed. The abdomen is deflated.



    • Skin incisions are closed with subcuticular 4-0 absorbable suture.




  • Sterile dressings are applied.



Adjustable gastric band





  • Gastrohepatic ligament window creation




    • After adequate exposure of the gastroesophageal junction, the peritoneum overlying the angle of His is divided with a Harmonic scalpel. The pars flaccida is opened, and the base of the right crus is identified.




  • Before the gastric band is placed, the band, its tubing, and port are tested for no leak and functioning well.



  • Band placement ( Fig. 5 A )




    • An opening is created at the base of the right crus, and the articulating band passer device is passed through the retrogastric tunnel to the left side and held in place. The band is then placed in the abdominal cavity and attached to the band passer. Once the band is placed well, it is then locked around the upper portion of the stomach.




    Fig. 5


    The LAGB. ( A ) Passing the adjustable gastric band behind the posterior stomach wall through a window in the gastrohepatic ligament (pars-flaccida technique). ( B ) Placing a few loose, simple interrupted plication sutures over the band anteriorly to reduce risk of band slippage and stomach herniation.

    ( Reprinted with permission, Cleveland Clinic Center for Medical Art & Photography © 2006-2016. All Rights Reserved.)



  • Stomach-band stay suture (see Fig. 5 B)




    • Two gastrogastric plication sutures are placed using 0 silk sutures, and the removable attachment of the band is then removed through the 15-mm trocar site.




  • Port placement




    • A subcutaneous pocket is created at the right paramedian 15-mm trocar site. The band tubing is brought out through that opening. The fascia is cleared inferior and lateral to the exit site, and the tubing is pushed into the abdomen without any tension. The port applicator is used to secure the port to the fascia so it is held in good position.




  • Final laparoscopic inspection to look for the band position; no kinks or twisting of the tubing.



Roux-en-Y gastric bypass


Roux-en-Y gastric bypass is one of the commonest metabolic surgery performed with excellent weight loss and metabolic disease improvement ( Fig. 6 ).




Fig. 6


The steps in the authors’ laparoscopic RYGB approach. ( A ) Once pneumoperitoneum is created and ports are inserted as mentioned in the text, the transverse colon and omentum are reflected superiorly to the upper abdomen and the ligament of Treitz is identified. The assistant should hold the mesocolon upward with a grasper to maintain adequate exposure during creation of the JJ. ( B ) “C” configuration of the proximal jejunum toward the camera helps in the orientation of the proximal and distal segments. The jejunum is divided 50 cm from the ligament of Treitz with a 60-mm load stapler. ( C ) The Roux limb is measured distally from the marked stitch for a distance of 150 cm. ( D ) JJ anastomosis. The bowel should be straightened (not stretched) against a rigid measuring device such as a marked grasper to determine the proper Roux limb length. Once the appropriate length is measured, a suture is placed to approximate the biliopancreatic limb and the Roux limb side by side. With the assistant holding upward on the stay suture, small adjacent enterotomies are made with an ultrasonic dissector and a 60-mm load stapler is applied, to create an end-to-side JJ anastomosis. The enterotomy site is closed with another 60-mm load stapler. A supportive stitch is placed at the far angle of the enteroenterostomy using 2-0 nonabsorbable suture. An antiobstruction stitch is placed to approximate the Roux limb to the biliopancreatic limb with 2-0 nonabsorbable suture. The residual mesenteric defect is closed with running 2-0 nonabsorbable suture. ( E ) The patient is then placed in the reverse Trendelenburg position. The omentum is split down the middle using an ultrasonic dissector to reduce tension. The Roux limb is then advanced to an antecolic antegastric fashion up toward the stomach. ( F ) Gastric pouch creation. A window is created in the gastrohepatic ligament with an ultrasonic dissector. After the anesthesiologist removes all intragastric devices, a 60-mm load stapler is fired across the mesentery of the lesser curvature, and 3 × 60-mm load staplers are fired across the gastric cardia to create a 15-mL gastric pouch. Staple lines are examined on both sides and hemostasis is secured. ( G ) The end of the Roux limb is sutured to the posterior aspect of the gastric pouch using 2-0 nonabsorbable suture. Enterotomies are made in the gastric pouch and in the Roux limb with an ultrasonic dissector. A 60-mm load stapler is inserted approximately 2 cm into the pouch and applied to create a stapled end-to-end gastrojejunostomy (GJ). Alternatively, a circular stapler can be used or a hand-sewn technique to create the GJ (see later discussion). ( H ) GJ anastomosis flexible endoscopy is performed. The scope is passed down the esophagus through the anastomosis and into the Roux limb. The enterotomy is closed with the endoscope in place as a stent. It is closed in running fashion to bring in both corners and tie in the middle using 2-0 nonabsorbable suture. A second anterior layer with 2-0 nonabsorbable suture has approximated the Roux limb and encompassed the gastric pouch staple line beginning from the greater curvature side to the lesser curvature side. ( I ) The final anatomic RYGB.

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Sep 7, 2017 | Posted by in GASTOINESTINAL SURGERY | Comments Off on Surgical Treatment of Obesity and Diabetes

Full access? Get Clinical Tree

Get Clinical Tree app for offline access