Surgical Management of Apical Prolapse


Vaginal approach

Abdominal approach

Vaginal hysterectomy + McCall culdoplasty

Abdominal sacrocolpopexy

Sacrospinous ligament suspension

Abdominal sacrohysteropexy

High uterosacral ligament suspension

Abdominal uterosacral suspension

Iliococcygeus fixation

High levator myorrhaphy




Vaginal Approach


In most parts of the world, surgical treatment of uterovaginal prolapse is the traditional vaginal hysterectomy (VH) with or without anterior and posterior repair [5]. Combining this with plication of the uterosacral ligaments (McCall’s culdoplasty) or high uterosacral ligament suspension (HUSL) recreates the level I support of vaginal apex.


McCall’s Culdoplasty


McCall described culdoplasty in 1957, where purse-string sutures were used to plicate the uterosacral ligaments along with the peritoneum to support the post-hysterectomy vaginal cuff [6]. The technique has been in regular use since then with modifications.

Culdoplasty technique usually involves placement of internal and external sutures on the uterosacral ligament after hysterectomy and plicating them in the midline. About one to three internal sutures are placed from the uterosacral ligament of one side to the opposite side, incorporating the peritoneum in between. This obliterates the cul-de-sac and reduces the risk of postoperative enterocele. The external or distal sutures on the uterosacral ligament anchor the ligament to the vaginal vault. The close proximity of the ureter at the cervical end of the uterosacral ligament should be borne in mind during McCall’s culdoplasty.

The shortening and plication of the distal uterosacral ligaments in midline appears to be effective in apical support. The success rate has been quoted as high as 90 % at the end of a year to about 85 % in a 4–9-year follow-up study [7]. In a study comparing the sacrospinous ligament fixation with McCall’s culdoplasty, recurrence in the anterior compartment was less frequent with the culdoplasty [8].


High Uterosacral Ligament Suspension (HUSL)


The technique of HUSL suspension was first described by Miller in 1927 [9]. The suspension procedure can be employed for vault support either at the end of the hysterectomy or for vaginal vault prolapse. In HUSL, the uterosacral ligament portion, proximal to the ischial spine, is used to suspend the vaginal apex along with incorporation of the anterior and posterior vaginal walls to create a pericervical ring.

The technique has been described in detail and popularized by Shull et al. in the last decade [10]. The uterosacral ligaments are identified posteromedial to the ischial spines at the 4 o’clock and 8 o’clock positions. The transverse portions of the pubocervical and rectovaginal fascia are identified, and bowels are packed away. Traction is applied on the uterosacral ligaments, and the strong suspensory ligament tissue towards the sacrum is traced. In the original technique, three double-armed, nonabsorbable sutures were placed through the ligament on the sacral side of ischial spine. The first suture is closer to the ischial spine and the other two sutures are then placed posterior and medial to the initial suture. This is repeated on the opposite uterosacral ligament. Once the sutures are placed on either side, pack is removed and the double-armed sutures are used to secure the transverse portions of the pubocervical and rectovaginal fascia. Before the sutures are tied, 5 ml Indigo carmine is given intravenously. The sutures are then tied in sequence bringing the pubocervical and rectovaginal fascia together at the apex. Cystoscopy is performed to check ureteral patency, and the suspensory sutures are trimmed. The risk of ureteral kinking makes it mandatory to perform cystoscopy during this procedure. This technique appears to provide good support using the native tissue in the vaginal approach (Fig. 15.1).

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Fig. 15.1
Sagittal section showing suture passing through pubocervical fascia (PCF), uterosacral ligament (USL), and rectovaginal fascia (RVF). B bladder, PS pubic symphysis, R rectum (From Shull et al. [10]; with permission)

In the case series by Shull et al., the anatomical success rate using Baden-Walker scoring system was 87 % for all sites with follow-up over 3.5 years [10]. A meta-analysis of the HUSL suspension has shown successful outcome for apical compartment to be 98 %, for anterior compartment 81 %, and 87 % for posterior compartment [11]. With a low overall recurrence of 4–18 % and a reoperation rate of less than 7 %, it is an effective procedure addressing the apical prolapse. In addition, the procedure also maintains the normal vaginal axis and appropriate vaginal length.


Complications

The major disadvantage of the procedure is the risk of ureteric injury varying from 1 to 11 % [10, 12]. The average distance between the uterosacral ligaments and the ureter at the cervical end is 0.9–1.4 cm, and moving towards the sacrum, the distance between the two is increased. At the intermediate portion beyond the ischial spines, where the suspension sutures are placed, the ureter is about 2.3–2.7 cm away from the ligament. Ureteral kinking can occur at this site and cystoscopy is important to visualize a free spill of dye on either side after suture placement. If there is no spill of dye-colored urine on any side, the sutures on that side should be cut one by one until spill is visualized. Once patency is established, there is no need to catheterize the ureter (Fig. 15.2).

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Fig. 15.2
Relation of the uterosacral ligaments to the S1–S4 trunk of the sacral plexus and their close proximity to uterosacral ligament sutures. Ureter cut portion to depict its relationship to uterosacral ligament and sacral plexus. USL uterosacral ligament, SSL-C sacrospinous ligament coccygeus muscle complex

New-onset neuropathic pain postoperatively has been reported following HUSL suspension. The presenting feature being sharp, stabbing pain radiating from buttocks posteriorly to the legs usually after the first 24 h of the procedure [13]. Entrapment of S1 to S4 nerves appears to be the cause of neuropathic pain. Removal of the uterosacral ligament suture on the affected side has been shown to relieve the pain, with complete resolution of symptoms in 6 weeks [14]. The close relationship of the sacral plexus to the uterosacral ligament makes it vulnerable to injury. The S1 trunk of the sacral plexus passes under the ligament about 3.9 cm superior to the ischial spine, the S2 trunk passes at 2.6 cm under the ligament, the S3 trunk passes at 1.5 cm, and the S4 trunk passes under the ligament at 0.9 cm, superior to the ischial spine [15]. The close relationship makes the sacral nerves vulnerable to injury and entrapment.

HUSL in experienced hands is an effective procedure for apical prolapse using the native tissue, but the risk of ureteric injury mandates assessment of ureteral patency when this procedure is undertaken.


Sacrospinous Ligament Suspension (SSLS)


Sacrospinous ligament suspension was first described by Sederl (1958) and was popularized by Nichols and Randall [16]. SSL suspension aims to suspend the vault to the sacrospinous ligament. The ligament can be approached either via the anterior or posterior approach, most surgeons commonly choosing the posterior approach. Sutures are placed on the sacrospinous ligament and are secured to the vaginal vault. Tying these sutures, moves the vault towards the sacrospinous ligament and suspends the apex.

The technique involves a midline posterior vaginal wall incision and entering the rectovaginal space laterally. The ischial spine is palpated and the rectal pillars are dissected by a combination of sharp and blunt dissection. The sacrospinous ligament is palpated and viewed, passing medially and posteriorly from the ischial spine. The upper border of the ligament is palpated and delayed absorbable sutures are placed about one to two fingerbreadths medial to the spine, ensuring the suture lies inferior to the upper border and not around the upper border. The pudendal neurovascular bundle, sacral plexus, and sciatic nerve are in close proximity to the ischial spine and above the superior border of the ligament. Care is also taken to avoid the whole thickness of the ligament during suture placement. Two sutures are usually taken, and in bilateral procedures, the technique is repeated on the opposite side. The sutures are then passed through the vaginal wall on either side of midline and are held. The enterocele, anterior and posterior vaginal walls are repaired if indicated, and the upper portion of the posterior vaginal wall incision is closed. The sacrospinous ligament suspension sutures are then tied, moving the vaginal vault towards the ligament, making sure there is no suture bridge in between. The posterior vaginal incision is then closed entirely.

Success rate of SSLS has been quoted to vary from 67 to 94 % in several case series, with the mean follow-up varying from 22 to 83 months in different studies [17]. The variation partly being related to the fact that the anatomical outcomes have not been evaluated using a common grading system in all studies and also the recurrence in different compartments have been reported together in some (Table 15.2) [18].


Table 15.2
Cure rates for sacrospinous ligament suspension



















































 
Authors

No. of patients

Follow-up (mean duration of follow-up) (years)

Cure rate (%)

1

Benson et al. (1996) [19]

42

1–5

67

2

Sze et al. (1999) [20]

54

0.6–6

77

3

Shull et al. (1992) [21]

81

1–5

82

4

Morley and DeLancey (1988) [22]

92

0.1–11

90

5

Maher et al. (2004) [23]

48

0.6–5

69

6

Meschia et al. (1999) [24]

91

1–6.8

94

In evaluating the recurrence of POP in different compartments following SSLS, the change in vaginal axis appears to be a determinant factor. The vaginal configuration is altered with the suspension, and the study by Rane et al. and Sze et al. using MRI showed there is alteration of the vaginal axis to an exaggerated posterior direction with SSLS [25, 26]. This increases the stress on the anterior compartment in standing and Valsalva disproportionately, which in turn amplifies the risk of anterior compartment prolapse. A study on long-term follow-up after SSLS shows the recurrence in anterior compartment 29 %, posterior compartment 5 %, and the apical 7 % [27]. Several case series have shown similar recurrence rates with anterior wall recurrence around 6–28.5 % and apical recurrence 2.4–19 % with SSLS [28].


Complications


The intraoperative complications reported in an analysis of 195 cases by David-Montefiore includes, vascular injury in 0.5 %, rectal injury in 0.4 %, and the need for blood transfusion in 5.2 % [29]. Buttock pain is a problem with SSLS, reported in about 3 % of patients and usually resolves in 6 weeks time. In pain persisting beyond 6 weeks, there appears to be a 50 % risk of significant long-term pain, and release of suture may have to be considered in these patients [30].

Pudendal and sacral neurovascular injuries are the serious complications of SSLF. The efficacy of the SSLS as a vaginal procedure for apical prolapse is well recognized and studies assessing the route of repair have largely compared SSLS with abdominal sacrocolpopexy.


Iliococcygeus Suspension


The iliococcygeus suspension recommended as an alternative to SSLS was first described by Inmon and involves fixing the vaginal vault to the iliococcygeus fascia just anterior to the ischial spines. The vault is secured bilaterally to the iliococcygeus fascia on either side [31, 32]. It is easier to perform than SSLS, but there are no RCTs favoring the iliococcygeus fixation over SSLS. The objective cure rate of 96 % has been reported in a case series with follow-up over 13 years [33].


Levator Myorrhaphy


A wide midline plication of the levator muscle is performed, and the vaginal cuff is attached to it in levator myorrhaphy [34]. In a prospective randomized study, comparing the high levator myorrhaphy with HUSL suspension, apical suspension is achieved in 96.7 %. However, the mean total vaginal length was significantly shorter after levator myorrhaphy [35], and sexual function is likely to be compromised with this technique.


Abdominal Route



Abdominal Sacrocolpopexy (ASC)


In abdominal sacrocolpopexy, the vault is secured to the anterior surface of sacrum at the level of S1–S2 by a graft material. The procedure was originally described by Lane [36]. Conventionally done as an open technique, ASC can also be performed using laparoscopic and robotic approaches.

In the open technique, the vaginal vault is lifted from below using an end-to-end anastomosis sizer (EEA) or a similar instrument (Fig. 15.3). The peritoneum over the vault is incised, and the vesicovaginal and rectovaginal spaces are entered along the proximal portion of the anterior and posterior vaginal wall. This area is used for securing the graft to the vaginal walls. Polypropylene mesh is commonly used as a graft material. Addison et al. promoted the use of two separate graft strips for the anterior and posterior vaginal wall, so that the tension on both is varied and spread out [37]. Two straps of meshes are secured, each to the anterior and posterior vaginal walls using multiple delayed absorbable or permanent sutures. In the recent past, commercially designed Y-shaped meshes have become available for use in ASC (Fig. 15.4). The depth of the graft extent distally is determined by the extent of anterior and posterior wall prolapse. In cases of perineal descent associated with vault prolapse, extending the posterior graft up to the perineal body, termed as colpoperineopexy, has been described [38].

A319837_1_En_15_Fig3_HTML.jpg


Fig. 15.3
End-to-end anastomosis sizer used for elevating the vaginal vault


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Fig. 15.4
Y-shaped manufactured mesh

The anterior longitudinal ligament overlying the sacrum is exposed, taking care to identify the sacral vessels in this area and avoiding them. The close proximity of common iliac vein, middle sacral artery, ureter, sigmoid mesocolon, and sacral vessels in this area demands meticulous dissection. Apart from the median sacral artery, other accessory vessels have been shown to traverse the presacral space, and dissection in this area should take into account these anatomical aberrations.

The proximal free ends of both the anterior and posterior graft materials are secured to the anterior longitudinal ligament at the level of S1–S2, using a nonabsorbable suture or bone anchors. It is important to anchor the graft without tension. Anchoring the graft to sacral promontory will place the vagina under tension and alter the vaginal axis. If graft fixation is attempted below the level of S3, risk of hemorrhage in the presacral space is increased. The graft material once secured is placed along the sacral curvature and re-peritonealized. It is recommended that the peritoneum is closed over the graft material to reduce the risk of bowel obstruction.


Table 15.3
Cure rate for abdominal sacrocolpopexy



































 
Authors

No. of patients

Follow-up (mean duration of follow-up)

Cure rate

1

Cundiff et al. (1997) [38]

19

11 weeks

100 %

2

Timmons et al. (1992) [39]

163

33 months

99 %

3

Reddy and Malik (2002) [40]

11

60 months

100 %

4

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Jul 5, 2017 | Posted by in UROLOGY | Comments Off on Surgical Management of Apical Prolapse

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