Ollman MM, Wilson BD, Yang YK et al (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135–138

Fong TM, Mao C, MacNeil T et al (1997) ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. Biochem Biophys Res Commun 237:629–631PubMed

Cone RD, Lu D, Koppula S et al (1996) The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res 51:287–317PubMed

Benoit SC, Schwartz MW, Lachey JL et al (2000) A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci 20:3442–3448PubMed

Yaswen L, Diehl N, Brennan MB et al (1999) Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nature Med 5:1066–1070PubMed

Huszar D, Lynch CA, Fairchild-Huntress V et al (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131–141PubMed

Krude H, Biebermann H, Luck W et al (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Gen 19:155–157

Koylu EO, Couceyro PR, Lambert PD, Ling NC et al (1997) Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland. J Neuroendocr 9:823–833

Kristensen P, Judge ME, Thim L et al (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 393:72–76PubMed

Sipols AJ, Baskin DG, Schwartz MW (1995) Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44:147–151PubMed

Baskin DG, Wilcox BJ, Figlewicz DP et al (1988) Insulin and insulin-like growth factors in the CNS. Trends Neurosci 11:107–111PubMed

Schwartz MW, Seeley RJ, Woods SC et al (1997) Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46:2119–2123PubMed

Spina M, Merlo-Pich E, Chan RK et al (1996) Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science 273:1561–1564PubMed

Li C, Vaughan J, Sawchenko PE et al (2002) Urocortin III-immunoreactive projections in rat brain: partial overlap with sites of type 2 corticotrophin-releasing factor receptor expression. J Neurosci 22:991–1001PubMed

Inui A (2000) Transgenic approach to the study of body weight regulation. Pharmacol Rev 52:35–61PubMed

Härfstrand A, Fuxe K, Agnati LF et al (1986) Studies on neuropeptide Y-catecholamine interactions in the hypothalamus and in the forebrain of the male rat. Relationship to neuroendocrine function. Neurochem Int 8:355–1376PubMed

Sakurai T, Amemiya A, Ishii M et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573–585PubMed

Yamanaka A, Sakurai T, Katsumoto T et al (1999) Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight. Brain Res 849:248–252PubMed

Hara J, Beuckmann CT, Nambu T et al (2001) Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 200130:345–354

Wang J, Osaka T, Inoue S (2001) Energy expenditure by intracerebroventricular administration of orexin to anesthetized rats. Neurosci Lett 315:49–52PubMed

Griffond B, Risold PY, Jacquemard C et al (1999) Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area. Neurosci Lett 262:77–80PubMed

Cai XJ, Widdowson PS, Harold J et al (1999) Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes 48:2132–2137PubMed

Stratford TR, Kelley AE (1997) GABA in the nucleus accumbens shell participates in the central regulation of feeding behavior. J Neurosci 19:121–131

Berridge KC, Pecina S (1999) Benzodiazepines, appetite, and taste palatability. Neurosci Biobehav Rev 37:735–740

Merali Z, McIntosh J, Anisman H (1999) Role of bombesin-related peptides in the control of food intake. Neuropeptides 33:376–386PubMed

Fathi Z, Corjay MH, Shapira H et al (1993) BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. J Biol Chem 268:5979–5984PubMed

Johansson JO, Jarbe TU, Henriksson BG (1975) Acute and subchronic influences of tetrahydrocannabinols on water and food intake, body weight and temperature in rats. Life Sci 5:17–27

Gonzalez S, Manzanares J, Berrendero F et al (1999) Identification of endocannabinoids and cannabinoid CB(1) receptor mRNA in the pituitary gland. Neuroendocrinology 70:137–145PubMed

Devane WA, Hanus L, Breuer A et al (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946–1949PubMed

Williams CM, Kirkham TC (1999) Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. Psycopharmacol 143:315–317

Arnone M, Maruani J, Chaperone F et al (1997) Selective inhibition of sucrose and ethanol intake by SR141716, an antagonist of central cannabinoid (CB1) receptor. Psycopharmacol 132:104–106

Di Marzo V, Goparaju SK, Wang L et al (2001) Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410:822–825PubMed