N
Mean age
Mean follow up (mo)
OR time (min)
Hospital LOS (d)
Complications
Success rates (%)
Definition of success
Song et al. 2017 [16]
LP
RAP
30
10
Peds
Peds
20.1
16.6
197.4 ± 38.9
254.1 ± 46.0
5.8 ± 1.4
3.2 ± 1.0
13.3
0
90
100
Symptoms, US, renogram
Silay et al. 2016 [17]
LP
RAP
390
185
Peds
Peds
45.2
12.8
173.8 ± 55.2
173.1 ± 50.7
4.6 ± 2.4
2.1 ± 2.1
15.1
7
97.7
99.5
Symptoms, US, renogram
Patel et al. 2016 [18]
LP
RAP
13
55
Peds
Peds
NR
NR
259.8
237
1.67
1.17
0
3.6
91.7
100
Symptoms, US, renogram
Ganpule et al. 2015 [19]
LP
RAP
25
19
Peds
Peds
24.8
18.3
167.4 ± 49.7
155 ± 46.6
5.0 ± 1.6
3.5 ± 1.5
4
5.3
96
94.6
Symptoms, IVU, renogram
Pahwa et al. 2014 [20]
LP
RAP
30
30
34.4
32
18
13.5
191.6
141.7
3
2.5
NR
NR
96.7
96.7
Symptoms, renogram
Basatac et al. 2014 [21]
LP
RAP
16
15
34.3
32.9
12
36
130 ± 45
114 ± 26
2.8 ± 0.75
2 ± 1
6.3
6.7
93.8
93.3
Symptoms, renogram
Danuser et al. 2014 [22]
LP
RAP
33
131
42.8
45.4
34.1
19.2
277.7 ± 72.3
181.6 ± 46.8
7.3 ± 2.8
5.1 ± 1.4
18.2
16.8
100
98.5
Symptoms, IVU, renogram
Riachy et al. 2013 [23]
LP
RAP
18
46
Peds
Peds
43
22
298
209
1
2
11.1
4.3
94.4
100
Symptoms, US, renogram
Kumar et al. 2013 [24]
LP
11
25
1.4–2.8
150
2.9
0
100
Renogram
RAP
19
21
1.4–2/8
129
2.8
0
100
–
Olweny et al. 2012a [25]
LP
10
35.8
9.2
188 ± 12.4
2.6
20
87.5
Symptoms, renogram
RAP
10
40.3
2.76
226 ± 36.7
2.6
10
100
Subotic et al. 2012 [26]
LP
RAP
20
19
Peds
Peds
21
10
248
165
7
6
25
31.6
100
100
Symptoms, US, renogram
Garcia-Galisteo 2011 [27]
LP
33
33.9
20.6
152.1 ± 23.3
4.5 ± 1.5
51.5
93.9
Symptoms, creatinine, renogram
RAP
17
33.9
42.5
121.6 ± 13.3
2.4 ± 0.5
23.5
94.1
Hemal 2010 [28]
LP
30
28.1
145 ± 44
5.5 ± 3.8
10
97
–
RAP
30
24.9
99 ± 29
2.5 ± 0.8
3.3
93
–
Kim et al. 2008 [29]
LP
58
Peds
18.1
196 ± 38
0.9 ± 0.23
3.4
97
Symptoms, renogram
RAP
84
Peds
10.1
188 ± 45.8
1.5 ± 0.55
0
99
Link et al. 2006 [30]
LP
10
38.0
5.6
80.7 ± 21.9
NR
0
90
NR
RAP
10
46.5
5.6
100.2 ± 9.1
NR
10 (1 delayed urine leak)
90
–
Weise and Winfield 2006 [31]
LP
14
24.5
10
271
2
0
100 (T), 64 (S)
“Technical” (T) – renogram
RAP
31
26
6
299
2
0
97 (T), 66 (S)
“Strict” (S) – symptoms and renogram
Four systematic reviews comparing RAP and LP have been published [9, 32–34]. The systematic review and meta-analysis by Braga et al. in 2009 analyzed eight available studies at that time and compared the outcomes of the two approaches [9]. They noted that although there was a 10-min advantage with the RAP, this did not translate into statistical significance. Five of the eight studies had a shorter hospital stay (by 0.5 days) for the robotic approach, which was statistically (if not clinically) significant. Both RAP and LP had similar complication rates and success rates. A more recent meta-analysis comparing RAP to LP reviewed 12 studies with 347 and 299 cases of RAP and LP, respectively [32]. This meta-analysis noted advantages of a shorter suturing time and hospital stay with the robotic approach. Interestingly, while there was no significant difference in total operative times, a subgroup analysis of suturing time found an 18 min advantage with RAP, based on a meta-analysis of four studies. It is conceivable that the time gained with suturing is balanced by docking and undocking of the robot [30] and the potentially faster dissection to expose the retroperitoneum and ureter with pure laparoscopy. Hospital stay was significantly shorter by 0.75 days in the RAP group, and again, there were no differences in success or complication rates. Conversely, another systematic review and meta-analysis by Autorino et al. of nine studies (277 RAP and 196 LP cases) found that RAP was associated with a significantly shorter operative time with no significant difference in hospital stay, complication, or success rates [33]. The most recent analysis by Light et al. [34], specifically focusing on those studies exclusively performing the dismembered technique, included 17 studies and confirmed a 27-min shorter operative time for RAP (p = 0.003) potentially reflecting increased efficiency in operative performance as well as robotic set up/undocking with experience of the technique to compound the effect on overall operative time observed in earlier analyses. RAP was also shown to have a 1.2-day shorter hospital stay (p < 0.001) and significantly lower complication rate (p = 0.005) and higher success rate (p = 0.008). This study did highlight the tremendous study heterogeneity and deemed the level of evidence to be “low” based on the quality of the studies (using a modified Newcastle-Ottawa scale) with a high-quality randomized controlled trial required to strengthen these conclusions.
Despite some of the conflicting data from these meta-analyses, the literature to date suggests that both LP and RAP provide excellent outcomes with low complication rates. However, the shorter learning curve associated with RAP is likely responsible for its rapid adoption in many minimally invasive practices including pyeloplasties, as demonstrated by one national surgical trend analysis where open and RAP was each performed in 45% of cases, while only 10% of cases were done laparoscopically [14].
Retroperitoneal Versus Transperitoneal Approach
The UPJ can be accessed via a transperitoneal or retroperitoneal route. Although most laparoscopic or robot-assisted urological surgeries are performed transperitoneally, there may be unique advantages with the retroperitoneal approach as it provides direct access to the renal pelvis and hilar vessels without the need for colonic reflection, avoids urine leak into the peritoneal cavity, and potentially hastens recovery. This may also be the approach of choice in obese patients or those who have had multiple prior abdominal surgeries. Outcomes of both retroperitoneal and transperitoneal approaches appear similar. The original description of retroperitoneal RAP was in the pediatric population in 2004 [35]. Subsequently the first report in adults was by Kaouk and colleagues in 2008 [36]. In this series, all cases were performed by a single surgeon with prior experience in retroperitoneal LP. Retroperitoneal access was achieved through a 1.2-cm incision at the tip of the 12th rib and subsequently, the lumbodorsal fascia incised and retroperitoneal space developed by balloon dissection. The authors indicate that although the transperitoneal approach affords the advantage of familiarity of the operative field, and a larger working space, there are significant benefits for the retroperitoneal approach such as lower risk of bowel injury and direct approach to the UPJ. In retroperitoneal LP series, the technical challenge of intracorporeal suturing was exacerbated by the smaller working space in the retroperitoneum and finding a potential crossing vessel was also more challenging. However according to Kaouk and coauthors, the wristed instrumentation of the da Vinci system helped overcome the limitation of working in a confined space. The outcomes and complications were also similar to that of standard transperitoneal RAP. Cestari et al. published their series of retroperitoneal versus transperitoneal RAP in 36 and 19 patients, respectively [37]. These authors also found similar outcomes in the two groups but noted similar challenges for the retroperitoneal approach, namely, gaining access, limited working space, and the loss of familiar anatomic landmarks. The confined space can also make identification of crossing vessels more difficult as evidenced by a recurrence caused by failure of recognition of one within the retroperitoneal cohort. The authors also noted that antegrade stent placement is more challenging during retroperitoneal RAP [37]. This, however, can be overcome with retrograde placement with flexible cystoscopy without any interruption in the procedure. A recently published randomized comparison of the two approaches performed robotically by a single surgeon (40 patients in each group) showed no significant difference in operative time, hospital stay, success or complication rates [38].
Given the paucity of literature comparing the two approaches, no conclusive statements regarding the superiority of one approach versus the other cannot be made at this time. The choice to pursue the retroperitoneal approach remains largely based upon the surgeon’s preference and experience with the technique and could be considered advantageous in certain situations such as in the presence of extensive intraperitoneal adhesions. The remainder of this chapter will focus on the transperitoneal approach.
LESS Robotic Pyeloplasty
With the emergence of a LP and RAP , laparoendoscopic single-site surgery (LESS) has been of interest in an effort to further minimize surgical invasiveness and potentially recovery. In the pursuit of a “scarless” surgery and given the non-extirpative nature of pyeloplasty surgery, this may represent an ideal setting for a LESS approach as it offers patients improved cosmesis by decreasing the number of ports from 3 to 5 to a single periumbilical incision that is often concealed [39]. Although this approach further raises the level of complexity in performing the procedure, in experienced hands, complication rates are similar to those with other minimally invasive approaches [39]. Early reports with LESS have demonstrated equivalent outcomes compared to conventional LP, with no differences in hospital stay, analgesic requirements, and minor and major complications [40]. LESS can be performed using either laparoscopic or robotic approaches, but some surgeons have found the ergonomic challenges of LESS to be better addressed using the robotic platform. In particular, the wristed instrumentation, surgeon-controlled camera, and ability to electronically reassign the hand controls (“masters”) after crossing the instruments have been cited as particular advantages of robotic LESS. Technical feasibility of LESS in RAP has been demonstrated in a number of case series [41–43] with good short-term outcomes and the authors uniformly highlighting the reduced technical complexity and improved learning curve over LESS LP. A comparison of LESS LP with LESS RAP showed no difference in hospital stay, complications, or outcome except for a longer operative time in the robotic LESS cohort (226 vs. 188 min, p = 0.007) [25]. Despite the initial enthusiasm created with this approach, a lack of universal adoption and recent decline in the performance of LESS surgery was demonstrated in a survey of Endourological Society members [44]. The survey responders highlighted the need for a new robotic platform with modified instrumentation that allows improved suturing ability and reduced robotic arm clashing. The development of the purpose driven da Vinci SP® platform for single-port surgery may specifically circumvent some of these technical challenges to renew interest in LESS RAP and studies assessing this are eagerly awaited.
Robot-Assisted Laparoscopic Pyeloplasty: Equipment List
- 1.
da Vinci surgical system (Intuitive Surgical, Inc., Sunnyvale, CA) – Si® or Xi®
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