PSA Biology and PC Screening

PSA-based population screening for PC is not recommended by many authorities and should be limited to men with increased risks of developing the disease.

PSA is not a disease-specific marker for PC, and new parameters help to increase its specificity:

The F/T PSA ratio used for early PC detection before prostatic biopsy or to justify a second biopsy after a negative result.

The PSA kinetics (PSA velocity and PSADT) used in active surveillance and in follow-up of patients after curative treatment.

Promising newer biomarkers are under investigations, but the high costs may preclude their general use in the near future.

References

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