(1)
Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
Keywords
Hypothermia prevention after surgeryPrevention of hypothermia after surgeryPostoperative hypothermiaPerioperative hypothermiaIntravenous fluid warmingMild perioperative hypothermia, defined as a core body temperature between 34 and 36 °C, is common and preventable [1]. Without active interventions approximately 70 % of patient undergoing operations lasting 2 h or longer will become hypothermic [2]. This is of concern as mild perioperative hypothermia has been associated with adverse outcomes [1, 3]. This chapter will explore the causes of perioperative hypothermia, the potential adverse consequences for patients, and techniques and recommendations for avoiding inadvertent perioperative hypothermia.
Causes of Perioperative Hypothermia
Patients are frequently cool peripherally when they arrive in the operating theater (OR), wearing a thin gown with the body exposed to the cool hospital environment. General anesthesia then profoundly impairs our normal thermoregulatory responses [1]. Induction of anesthesia causes direct peripheral vasodilation, and decreases the threshold for shivering and vasoconstriction by 2–3 °C resulting in vasodilation and a distribution of heat from the core to the periphery (usually 2–4 °C cooler) which, without intervention, will decrease core temperature by 1–1.5 °C after 1 h of anesthesia [4]. This mechanism is accentuated when the periphery is already cool, with vasoconstriction constraining heat in the core and increasing the core-to-periphery gradient.
This initial redistribution, without intervention, is followed by a slower decrease in core temperature over the next few hours as heat loss exceeds heat production, with the rate depending on the size of the patient [4]. The addition of neuraxial anesthesia (spinal, epidural) will exaggerate these responses by further inhibiting vasoconstriction, so that active thermal management is especially important in patients with combined general and regional anesthesia [5].
Adverse Consequences of Perioperative Hypothermia
Even mild perioperative hypothermia (34–36 °C) has been shown in large randomized controlled trials (RCTs) to be associated with adverse outcomes. Most importantly for major gastrointestinal surgery mild hypothermia triples the risk of surgical site infection (SSI) by directly impairing immunity, and by causing vasoconstriction, which decreases oxygen delivery to the wound [3]. In animal models mild hypothermia also impairs resistance to bacterial infection.
Mild hypothermia also significantly increases blood loss and the relative risk of transfusion by about 20 % for each 1 °C drop in core temperature, which is substantial and clinically significant [6]. The mechanism is multifactorial: hypothermia impairs platelet function, primarily by impairing release of thromboxane A2 which is needed to form the initial platelet plug, as well as the function of enzymes in the clotting cascade [7]. This impairment in coagulation will not be apparent during routine coagulation screening as these tests are performed at 37 °C [8].
Prospective randomized controlled trials also show that mild hypothermia can cause other complications such as shivering (which increases oxygen consumption) [9], a threefold increase in adverse cardiac events [10, 11], and prolonged hospital stay [3]. Hypothermia also prolongs the duration of action of anesthetic and neuromuscular blocking agents that can result in delayed recovery [12]. Finally and importantly hypothermia is very unpleasant for patients, can persist for several hours, and is often remembered as one of the worst aspects of their perioperative experience [13]. This discomfort is also stressful for patients and elevates blood pressure, heart rate, and plasma catecholamine levels [14]. These factors, along with shivering, presumably contribute to the significant and serious increase cardiac events.
Temperature Monitoring
The patient’s temperature should be monitored perioperatively to help prevent inadvertent hypothermia, and also to enable warming to be adjusted to avoid hyperpyrexia which can occur in prolonged procedures with active warming, or if the patient develops a systemic inflammatory response syndrome (SIRS).
Core body temperature should be measured in patients undergoing general anesthesia for longer than 30 min. Core temperature can be reliably monitored at the tympanic membrane, pulmonary artery (with a pulmonary artery catheter), distal esophagus, or nasopharynx. Bladder, rectal, oral, and forehead skin temperatures can be measured clinically but may not reliably reflect core temperature.
Recommendations for Perioperative Care
Prevention of hypothermia mainly requires attention to detail and the adoption of a few simple measures during the patient’s perioperative journey.
Preoperative
Preoperative assessment is clinically important to help identify patients at risk of inadvertent perioperative hypothermia, and can help anesthesia providers prepare suitable warming methods. Patients at high risk have a high severity of illness on admission, low body mass index (BMI), age >65 years, and anemia, and are planned to undergo combined general and regional anesthesia, or major surgery [2, 15]. It is also important for anesthesia providers to be aware of the patient’s planned position during surgery, and the area available for warming devices; for instance the lithotomy position or “prepping in a leg” for a possible skin graft can significantly alter the options available for intraoperative patient warming.
The initial redistribution of heat from the central thermal compartment to cooler peripheral tissues is difficult to treat, but it can be reduced. Preoperatively, patients should be encouraged to be active if possible (e.g., walk to the operating department), which generates body heat. They should also be encouraged to verbalize when they feel cold. Patients should be nursed in a warm environment to minimize peripheral cooling. There is some evidence that pre-emptive skin surface warming for 1–2 h preoperatively is effective in reducing the initial redistribution of heat that occurs after induction of anesthesia [16]. The most important site is the legs, which is the largest contributor to the peripheral thermal compartment. If the patient’s preoperative temperature is below 36 °C, then it is advisable to start forced-air warming preoperatively.
Intraoperative
The most important factor in determining intraoperative heat loss is operating room temperature. Room temperatures above 23 °C in adults (up to 26 °C in infants) will help to maintain normothermia, but will be uncomfortable for the operating room staff. Therefore it is recommended that ambient temperature is maintained at 21 °C or above, especially during induction of anesthesia or when the patient is exposed; if normothermia is maintained, this may be reduced once active warming is established [17].
Airway Heating and Humidification
Approximately 10 % of metabolic heat production is lost via the respiratory tract, from both the heating and humidification of inspiratory gases. This can be reduced by routine humidification of airway gases, although the overall effect on core temperature is minimal [18].
Intravenous Fluid Warming
Administration of 1 l of intravenous (IV) fluid at room temperature (21 °C) or one unit of refrigerated blood decreases the core body temperature by approximately 0.25 °C. Therefore whilst patients cannot be warmed by using fluid warmers (fluid given cannot substantially exceed body temperature), heat loss can be prevented, especially when large amounts of fluid are given. Administration of warmed IV fluid has been shown to decrease the incidence of hypothermia in gynecologic, abdominal, and orthopedic surgery [19]. Their use has been recommended for all intraoperative IV infusions >500 ml in adults [17]. At low flow rates, there are no clinically important differences between any of the available fluid warmers. At higher flow rates the Hotline countercurrent water heat exchanger (Level 1 Technologies Inc, Rockland, MA, USA) consistently delivers the warmest fluid outlet temperatures [19]. During massive transfusion or whenever very high flow rates are needed, high volume systems with powerful heaters are recommended to deliver large amounts of warm fluid quickly (e.g., level 1 infusor, Belmont).
Cutaneous Warming Devices
The simplest way to decrease cutaneous heat loss is to apply a cotton blanket, or surgical drape to the skin to trap a layer of still air below the covering and act as a passive insulator. A single layer will reduce heat loss by approximately 30 %, with additional layers only adding marginal benefit [20]. Warming the blanket may increase patient satisfaction but has little benefit, and the benefit is short-lived [20]. Therefore passive warming can help to reduce heat loss but usually insufficient to prevent mild hypothermia.
The most common intraoperative warming systems are forced-air convective warming systems or forced-air warmers, which distribute heated air generated by a power unit through a specially designed blanket. About 90 % of metabolic heat is lost via the skin surface, and forced-air warmers have a dual benefit of almost completely eliminating this loss where they are sited, and transferring heat to the body. Heat transfer per unit area is relatively low, but as long as a large surface area is available for heating forced-air warmers are generally very effective and maintain normothermia even during major procedures [18, 21]. They are superior to passive insulation both in preventing hypothermia and rewarming already hypothermic patients [19]. Forced-air warming is also inexpensive and remarkably safe, and has therefore become the routine method of warming surgical patients. It is preferable to cover most of the exposed area when possible in order to counteract the heat loss coming from large abdominal incisions.
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