Smegmoma, Pearly penile papules, Hirsutoid papillomas.

The most common cystic lesion of the penis and prepuce is the smegma cyst, which sometimes called “smegmoma”, and usually seen under the unretractable prepuce, it may appear yellowish due to smegma content (Chap. 36) (Fig. 7.1).

Other penile cysts may affect the prepuce (Chap. 19), like epidermal inclusion cysts which may form after penile surgery; including circumcision and hypospadias repair, and penile girth augmentation surgery. Preputial cyst generally divided into two main categories: median raphe (urethroid) cysts and epidermoid (follicular) cysts (Chap. 19). Epidermoid cysts are the most common cystic lesions of the penis and occur primarily on the shaft. Median raphe cysts are midline developmental cysts that occur at sites from the external urethral meatus to the anus, including the ventral penis. Occasional examples are seen of true retention cysts of the prepuce and mucoid preputial cyst was rarely reported (Fig. 7.2).