Partial Nephrectomy


Guideline issuing organization


Tumor size


Solitary kidney


Bilateral tumors


Chronic kidney disease


Proteinuria


Surgical priority


AUA (2017)


<4 cm


Prioritize


Prioritize


Prioritize


Prioritize


Negative margins


Avoid prolonged warm ischemia time (<30 min)


NCCN (2017)


<4 cm – preferred


4–7 cm –consider


Appropriate


Appropriate


Appropriate


NC


NC


EAU (2014)


<4 cm – preferred


4–7 cm – favored if feasible


NC


NC


NC


NC


Surgical approach should be selected so as not to compromise oncologic or functional outcomes



AUA American Urologic Association, NCCN National Cancer Center Network, EUA European Association of Urologists, NC no comment




Multiple studies have sought to evaluate the role of partial versus radical nephrectomy in the treatment of small renal masses (T1a). EORTC 30904 randomized patients to one of the two approaches and found oncologic equivalence between the two modalities without demonstrable overall survival benefits between cohorts [4]. Conversely, the preponderance of observational studies on cT1 tumors have consistently demonstrated equivalent oncologic outcomes of partial nephrectomy compared to radical nephrectomy, with a survival and morbidity advantage favoring partial nephrectomy [58]. Kim et al. reported a 19% absolute risk reduction in all-cause mortality, 29% absolute risk reduction in cancer specific mortality, and a 61% absolute risk reduction for development of severe (stage IV–V) chronic kidney disease (CKD) [9]. Comparatively, analysis of the eGFR changes in the EORTC trial demonstrated that PN decreases the incidence of stage III CKD compared to RN but not stage IV or V CKD [10]. Due to the fact that a lower GFR has been linked to long-term cardiovascular complications [11, 12], current practice dictates that, when feasible, partial nephrectomy should be the preferred treatment for clinical T1 tumors and select patients with cT2 tumors, such as those with preexisting CKD, risk factors for medical CKD, a solitary kidney, or familial renal tumor syndromes [13].


Although the use of robotic partial nephrectomy has increased dramatically over the last decade [14], no randomized trials have compared open versus traditional laparoscopic or robotic partial nephrectomy (RPN). However, a meta-analysis of 3,418 patients across 8 studies demonstrated no difference between the three approaches regarding conversion rate to radical nephrectomy, blood transfusion rate, ischemia time, change in estimated glomerular filtration rate (eGFR), or surgical margin status [15]. RPN, however, is associated with a lower rate of conversion to open surgery or radical surgery with shorter ischemia time duration when compared to the laparoscopic approach [16]. When performing RPN, several authors have suggested that the learning curve to limit ischemia time is between about 15 to 30 cases based on surgeon experience as well as tumor complexity [1719].


Multiple varied factors should be contemplated during planning of robotic partial nephrectomy, including the ideal surgical approach (transperitoneal vs. retroperitoneal), potential for prolonged warm ischemia time based on tumor complexity [20], and intraoperative tumor excision techniques (enucleation vs. wedge resection or partial nephrectomy). In experienced hands and appropriately selected patients, the outcomes of RPN via either a transperitoneal or retroperitoneal approach provide similar outcomes [21] and the decision on the approach should be based on surgeon familiarity and tumor location (anterior vs. posterior). Warm ischemia should be limited to as brief as possible and preferably should be less than 25 min. In patients who may require longer ischemia times, consideration should be given to using intraoperative ice, early unclamping [22], and/or partial clamping [23]. Off-clamp (no ischemia) partial nephrectomy can be considered by experienced surgeons in patients with small, peripheral tumors in whom ischemia time is important as it preserves renal function in the perioperative period but does not appear to benefit long-term renal function [2326]. Tumor enucleation may be considered for patients with multiple masses or who need maximal parenchymal preservation but is associated with a higher positive margin rate (albeit without differences in local tumor recurrence) [27, 28].

Equipment list (transperitoneal and retroperitoneal approach)



  1. 1.

    30°-angled robotic lens


     

  2. 2.

    Veress needle (or Hassan port)


     

  3. 3.

    Trocars


    1. (a)

      (Transperitoneal):


      1. (i)

        Da Vinci Xi™: 3-, 8-mm robotic trocars and one 8-mm bladeless optical robotic trocar. A bariatric 8-mm trocar may be used for the fourth arm to open additional space between instruments


         

      2. (ii)

        Da Vinci Si™: 3-, 8-mm robotic trocars, one 12-mm trocar with visual obturator. A bariatric 8-mm trocar may be used for the fourth arm to open additional space between instruments


         

       

    2. (b)

      Retroperitoneal


      1. (i)

        Da Vinci Xi™: 3-, 8-mm robotic trocars and 1 Da Vinci robotic Hasson trocar


         

      2. (ii)

        Da Vinci Si™: 3-, 8-mm robotic trocars, one 12-mm Hasson trocar


         

       

     

  4. 4.

    Assistant trocars


    1. (a)

      Right sided: one, 5-mm trocar for liver retraction


       

    2. (b)

      Both sides: one 12-mm trocar (Airseal™, Conmed, Utica, NY)


       

     

  5. 5.

    Laparoscopic instruments


    1. (a)

      Short- and long-tip laparoscopic suction


       

    2. (b)

      Laparoscopic scissors


       

    3. (c)

      Laparoscopic bulldog vascular clamps


       

    4. (d)

      Needle driver (to bring suture in and out)


       

    5. (e)

      Laparoscopic ultrasound probe


       

    6. (f)

      Polymer locking ligation system (Weck®Hem-o-lok®, Teleflex™, Morrisville, NC)


       

    7. (g)

      Absorbable suture clip applier (Lapra-Ty™, Ethicon® US LLC, Cincinnati, OH)


       

    8. (h)

      Hemostatic agents (Floseal™, Baxter Healthcare, Deerfield, IL, or Surgiflo®, Ethicon® US LLC, Cincinnati, OH) with laparoscopic applier (optional)


       

    9. (i)

      Laparoscopic specimen bag


       

    10. (j)

      15Fr Round drain (optional)


       

     

  6. 6.

    Robotic instruments


    1. (a)

      Monopolar scissors


       

    2. (b)

      Fenestrated bipolar forceps


       

    3. (c)

      Prograsp forceps


       

    4. (d)

      Needle drivers × 2


       

     

  7. 7.

    Suture


    1. (a)

      6″ 2-0 barbed suture × 2 with Lapra-Ty applied proximal to the distal loop to oversew the deep resection bed.


       

    2. (b)

      5″ 0 polyglactin suture on V-20 needle × 4–6 with a Hem-o-lok clip and Lapra-Ty placed 2 cm from the end for the renorrhaphy. Placing a knot distal to the Lapra-Ty prevents slipping of the clips when being introduced through the trocar (Fig. 6.1). Dyed and undyed sutures can be prepared and alternated during the renorrhaphy.


       

    3. (c)

      4-0 or 5-0 polypropylene suture for vascular emergency.


       

    4. (d)

      Skin and fascial closure suture.


       

     

  8. 8.

    Adjunctive agents:


    1. (a)

      Indocyanine green (optional): 2.5 mg starting dose given immediately after hilar clamping [29]


       

    2. (b)

      Mannitol (optional) no longer used in our practice due to lack of evidence in its favor [30]


       

     

  9. 9.

    Kidney-shaped retroperitoneal dilating balloon (Spacemaker Structural Balloon dilator, Medtronic, Minneapolis, MN)


     

  10. 10.

    Emergency instrumentation (in room, not open)


    1. (a)

      Open nephrectomy instrumentation


       

    2. (b)

      Emergency wrench for robot platform


       

    3. (c)

      Laparoscopic stapler with vascular staple loads


       

     

../images/312378_2_En_6_Chapter/312378_2_En_6_Fig1_HTML.png

Fig. 6.1

Suture preparation for renorrhaphy


Robot-Assisted Partial Nephrectomy, Transperitoneal Approach


Introduction


The transperitoneal approach for partial nephrectomy is well suited as an approach for most renal tumors. For surgeons new to the robotic approach, the anatomy and approach are similar to the laparoscopic and open transperitoneal approaches. Important structures to be cognizant of while performing dissection include the liver, large bowel, duodenum, and the inferior vena cava on the right and the spleen, large bowel, pancreas, aorta, and superior mesenteric artery on the left. The transperitoneal approach is less suited for posterior tumors, which require complete mobilization of the kidney within Gerota’s fascia.


Step by Step





  1. 1.

    Ensure proper sutures and equipment have been prepared for the case per above specifications and that supplies for open conversion and a vascular stapler are within close proximity.


     

  2. 2.

    Positioning. The patient is placed in a modified flank position at 45–60° using Laminectomy bolsters. The patient’s iliac crest is positioned over the break in the table and the table is flexed, if needed, to open the hips and create space for the robotic arms. The patient is securely fastened to the bed and the upper arm is placed either on an arm support or pillows. All pressure points are padded adequately to prevent positioning injuries.


     

  3. 3.

    Pneumoperitoneum is established using either the Veress or open (Hasson) technique.


     

  4. 4.

    Port placement (Fig. 6.2). The initial optical port is placed under direct observation using the 8-mm robotic Visiport™ (Xi) or the 12-mm visible port (Si) (VeraOne™, Medtronic, Minneapolis, MN). The remainder of the robotic trocars are placed under vision with the two main working arms triangulating to the tumor and the fourth arm positioned just superior and medial to the iliac crest for upward retraction on the kidney. Use of the long bariatric robotic trocar for the fourth arm helps reduce clashing of the robotic arms. For right-sided cases, a 5-mm port is placed immediately inferior to the xyphoid process for insertion of a locking grasper that can be used for liver retraction. A 12-mm assistant port is placed 6–8 cm superiomedially to the camera port in line with the inferior robotic arm, fourth arm, and camera port.


     

  5. 5.

    Robot docking. The robot is brought in at a 15° angle toward the patient’s head with the arms positioned to provide maximal working space and limit instrument clashing. Instrumentation for the 4-arm approach includes a 30° down lens, monopolar scissors for the right hand, fenestrated bipolar forceps for the left arm, and a Prograsp forceps for the fourth arm.


     

  6. 6.

    Bowel reflection. The peritoneum is incised lateral to colon to reflect the colon medially. The proper plane of dissection is readily apparent by identifying the color difference between the pale fat of the retroperitoneum and the brighter yellow fat of the mesentery. On the left, dissection continues beyond the splenic flexure until the spleen lies medially without additional traction. Care must be taken to avoid injury to the vessels of the splenic hilum as well as the tail of the pancreas. On the right, care is taken to kocherize the duodenum medially. The peritoneum overlying the superior pole of the kidney is incised along the inferior aspect of the liver to allow for upward retraction during hilar dissection. A locking grasper is inserted through the sub-xyphoid port, passed beneath the liver, and affixed to the lateral body wall musculature to retract the liver superiorly. With either side, the medial dissection is complete once the adrenal is identified superiorly and the gonadal vein inferiorly.


     

  7. 7.

    Ureteral identification and hilar dissection. A 3–4 cm incision is made in Gerota’s fascia medial to the lower pole along the lateral side of the gonadal vein in order to identify the ureter (Fig. 6.3). The ureter and surrounding perinephric fat is lifted superiorly and the attachments to the posterior wall are bluntly dissected along the psoas muscle. The fourth arm is inserted into this opening to balance the kidney laterally and place the hilum on stretch.


     

  8. 8.

    Renal hilar dissection. Dissection continues medial to the ureter from inferior to superior by releasing the anterior fascia along the entirety of the medial surface of the kidney and separating the retroperitoneal fat into packets for ligation. The fourth arm tension should be continually adjusted to assure the hilum remains on stretch. Once the renal vein is identified, a window is created posteriorly to expose the renal artery. Preoperative cross-sectional imaging should be scrutinized closely for identification of accessory arteries and veins that may require additional dissection.


     

  9. 9.

    Lesion identification. The perinephric fat is carefully dissected from the renal capsule in the region of the tumor in order to expose several centimeters of normal renal capsule circumferentially around the tumor. For lateral and posterior tumors, the dissection should continue until the kidney can be rotated for adequate exposure. Fat may be removed and sent to pathology or left attached to the tumor surface to be used for retraction.


     

  10. 10.

    Lesion demarcation. An intraoperative ultrasound is used to verify the mass and systematically demarcate the boarders of dissection, assuring an adequate surgical margin. The fat over tumor can be left on a handle for dissection or removed at this point and sent for histologic analysis. Use of TilePro® allows for simultaneous visualization of the tumor and ultrasound (Fig. 6.4).


     

  11. 11.

    Preparation for dissection. It is imperative to assure all instrumentation is ready and available prior to clamping of the renal artery. Utilization of a routine checklist helps reduce the possibility of missing supplies/instrumentation. It is our practice to check that all ports are placed deep enough to expose the robotic remote center (thick black line on port) and prevent dislodgement during instrument exchange. Bulldog clamps (depending on the number vessels) are placed medial to the kidney in preparation for clamping.


     

  12. 12.

    Lesion excision. The hilum is placed on stretch and a bulldog clamp is placed on the renal artery(s) (Fig. 6.5). We do not routinely clamp the renal vein [31]. If desired, indocyanine green can be administered to ensure complete vascular control using the fluorescence light on the daVinci Robotic system (Firefly, Fig. 6.6). Using the monopolar scissors, the capsule and immediate underlying parenchyma are incised using electrocautery, followed by a combination of blunt and cold excision to dissect around the contour of the mass, leaving an adequate parenchymal margin. Intermittent cautery can be used to control any small vessels encountered during the dissection. The bed is inspected. If there appears a tumor at the deep resection margin, this can be excised separately, though we do not routinely send a deep margin (Fig. 6.7).


     

  13. 13.

    Closure of the excision bed. A 6-inch, 3-0 barbed suture with a Lapra-Ty at the end is used to over sew the base of the defect, with openings in the collecting system closed separately from vasculature when present. The process can be repeated with additional sutures as needed to assure the entire base has been over sewn. If planning an early clamping technique, the hilar clamps can be removed at this point and additional arteries can be over sewn.


     

  14. 14.

    Renorrhaphy. The renal defect is closed using the sliding-clip renorrhaphy technique [32] (Fig. 6.8). We start the suture at the side farthest from the assistant to allow for easier access for final clip placement. The suture is passed 1 cm from the renal defect in an interrupted fashion leaving approximately 1 cm of space between each suture. After all sutures are placed, a Hem-o-lock clip is applied, and the sutures are alternatively tightened to prevent excessive tension on any one individual suture.


     

  15. 15.

    The vascular clamps are removed keeping the renorrhaphy in view if possible. If bleeding is encountered, the sutures may be further tightened. When necessary, additional renorrhaphy sutures or hemostatic agents can be utilized to stop bleeding. Once all sutures are placed and tightened, Lapra-ty clips are used to secure the sliding clip (Fig. 6.9).


     

  16. 16.

    Completion of case. If there is a large defect in the renal collecting system or there is concern for postoperative leak, a drain can be introduced through the fourth arm port and placed inside of Gerota’s fascia. The fascia is then re-approximated with a vicryl or barbed suture. The specimen is placed into a laparoscopic bag and brought through an assistant port depending on location and the size of the specimen. The incisions are then closed, irrigated, and injected with local anesthetic.


     

../images/312378_2_En_6_Chapter/312378_2_En_6_Fig2_HTML.jpg

Fig. 6.2

Transperitoneal partial nephrectomy port placement. The initial port (camera port, “C”) is placed under direct observation using the 8-mm robotic Visiport™ (Xi) or the 12-mm visible port (Si) (VeraOne™, Medtronic, Minneapolis, MN). The two main working arms (WA) triangulate to the tumor and the fourth arm (4) is positioned just superior and medial to the iliac crest for upward retraction on the kidney. Use of the long bariatric robotic trocar for the fourth arm helps reduce clashing of the robotic arms. For right-sided cases, a 5-mm port is placed immediately inferior to the xyphoid process for insertion of a locking grasper for liver retraction. A 12-mm assistant port (AP) is placed 6–8 cm superiomedially to the camera port in line with the inferior robotic arm, fourth arm, and camera port. The midline is marked prior to the surgery in obese patients


../images/312378_2_En_6_Chapter/312378_2_En_6_Fig3_HTML.jpg

Fig. 6.3

After the colon is reflected, an incision is made in Gerota’s just off the lower pole (LP). Blunt dissection proceeds toward the psoas until the ureter (U) and gonadal vein are identified (G). The ureter is lifted anteriorly and the gonadal is displaced posteriorly until the psoas muscle is encountered. This allows for elevation of the kidney and renal hilum and for dissection to proceed cephalad to the renal hilum

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Oct 20, 2020 | Posted by in UROLOGY | Comments Off on Partial Nephrectomy

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