Together with Helmuth Madersbacher and others Ed McGuire is one of the most prominent promotors of urodynamic studies in Urology and has thus become a doyen of modern Neuro-Urology. In summary, the entire Chap. 11 by McGuire deals with the potential and limitations of urodynamics as a diagnostic tool to identify BPS/IC or to at least distinguish it from confusable disorders. The introductory statement by McGuire is still valid 30 years later, i.e. that urodynamics cannot provide the definite diagnosis of BPS/IC.

Whatever you prefer to call it, whatever sophisticated connotation or attribution you will add to your preferred definition or classification of this condition, first and foremost BPS/IC is a pain syndrome, a health constraint basically due to pain. Thus, the statement that “neurourological techniques have little to offer as a first step in the investigation of patients with this kind of symptomology” appears to be still correct and true. Moreover, patients are typically unhappy to undergo urodynamic testing, not infrequently complaining about discomfort and pain, sometimes resulting in anxiety [3, 6]. This is particularly true for patients with complaints of chronic pelvic pain syndromes.