Hepatocellular carcinomas can be further divided into distinct subtypes that provide important clinical information and biological insights. These subtypes are distinct from growth patterns and are on based on morphologic and molecular findings. There are 12 reasonably well-defined subtypes as well as 6 provisional subtypes, together making up 35% of all hepatocellular carcinomas. These subtypes are discussed, with an emphasis on their definitions and the key morphologic findings.
Key points
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Hepatocellular carcinomas show substantial morphologic variability.
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This morphologic variability segregates into distinct entities.
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These entities are called subtypes and have unique clinical, biological, and molecular findings.

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